Building 2D quasicrystals from 5-fold symmetric corannulene molecules

Nano Research - The formation of long-range ordered aperiodic molecular films on quasicrystalline substrates is a new challenge that provides an opportunity for further surface functionalization....     

Index calculus for abelian varieties of small dimension and the elliptic curve discrete logarithm problem

We propose an index calculus algorithm for the discrete logarithm problem on general abelian varieties of small dimension. The main difference with the previous approaches is that we do not make use of any embedding into the Jacobian of a well-suited curve. We apply this algorithm to the Weil restriction of elliptic curves and hyperelliptic curves over small degree extension fields. In particular, our attack can solve an elliptic curve discrete logarithm problem defined over in heuristic asymptotic running time ; and an elliptic problem over or a genus 2 problem over in heuristic asymptotic running time .     

A disaggregate Box-Cox Logit mode choice model of intercity passenger travel in Germany and its implications for high-speed rail demand forecasts

We show that enriching logit mode choice model specification by mode attributes, socio economic variables and trip purpose characteristics significantly improves model quality, and that Box-Cox transformations applied to model attributes imply an asymmetry of the reaction curve, as well as more reasonable properties (diminishing marginal values of time savings, elasticities and values of time that differ among the modes) than those of the linear logit model. Moreover, the model yielded very different high speed rail market shares for Germany than results obtained with the usual linear utility functions. Received: December 1996 / Accepted: April 1997     

Constructive and destructive facets of Weil descent on elliptic curves

In this paper we look in detail at the curves which arise in the method of Galbraith and Smart for producing curves in the Weil restriction of an elliptic curve over a finite field of characteristic 2 of composite degree. We explain how this method can be used to construct hyperelliptic cryptosystems which could be as secure as cryptosystems based on the original elliptic curve. On the other hand, we show that the same technique may provide a way of attacking the original elliptic curve cryptosystem using recent advances in the study of the discrete logarithm problem on hyperelliptic curves. We examine the resulting higher genus curves in some detail and propose an additional check on elliptic curve systems defined over fields of characteristic 2 so as to make them immune from the methods in this paper. Received January 2000 and revised December 2000 Online publication 29 August 2001     

Re-designed N-terminus enhances expression, solubility and crystallizability of mitochondrial protein

Mitochondrial aminoacyl-tRNA synthetases are key enzymes in translation. They are encoded by the nuclear genome, synthesized as precursors in the cytosol and imported. Most are matured by cleavage of their N-terminal targeting sequence. The poor expression of mature proteins in prokaryotic systems, along with their low solubility and stability after purification are major obstacles for biophysical and crystallographic studies. The purpose of the present work was to analyze the influence of additives on a slightly soluble aspartyl-tRNA synthetase and of the N-terminal sequence of the protein on its expression and solubility. On the one hand, the solubility of the enzyme was augmented to some extent in the presence of a chemical analog of the intermediary product aspartyl-adenylate, 5'-O-[N-(L aspartyl) sulfamoyl] adenosine. On the other hand, expression was enhanced by extending the N-terminus by seven natural amino acids from the predicted targeting sequence. The re-designed enzyme was active, monodisperse, more soluble and yielded crystals that are suitable for structure determination. This result underlines the importance of the N-terminal residue sequence for solubility. It suggests that additional criteria should be taken into account for the prediction of cleavage sites in mitochondrial targeting sequences.     

Surfaces of Al-based complex metallic alloys: atomic structure,thin film growth and reactivity

We present a review on recent work performed on periodic complex metallic alloy (CMA) surfaces. The electronic and crystallographic structures of clean pseudo-tenfold, pseudo-twofold, sixfold surfaces will be presented along with the recent findings on CMA of lower structural complexity, i.e. with a smaller unit cell. The use of CMA surfaces as templates for thin film growth and the formation of surface alloy will also be introduced. The reactivity of these complex surfaces and their impact in the field of heterogeneous catalysis will be discussed. Finally, common trends among these systems will be highlighted when possible and future challenges will be examined.     

Preservation of the pattern of tyrosine phosphorylation in human neutrophil lysates

Diabetic cardiovascular autonomic neuropathy increases the risk of deterioration in renal function and is associated with increased mortality in patients with renal failure. Type 1 diabetic patients with long diabetes duration, matched for age (38 +/- 9 years) and diabetes duration (28 +/- 8 years) were studied regarding the association between cardiovascular autonomic nerve function and different degrees of diabetic nephropathy. Eighteen patients were normo- (< 30 mg/l), six micro- (30-300 mg/l), and 13 macroalbuminuric (> 300 mg/l) based on urinary albumin concentrations in three separate morning samples. They were compared with 33 control subjects with similar age. Autonomic nerve function was evaluated by measuring the response of heart rate to deep breathing and active standing. Beat-to-beat finger artery blood pressure (Finapres) was tested during active standing. During deep breathing both change in heart rate (17 +/- 11, 9 +/- 7 and 4 +/- 3 beats/min) and ratio between expiratory and inspiratory R-R intervals (1.32 +/- 0.24, 1.14 +/- 0.15 and 1.05 +/- 0.04) decreased from normo- over micro- to macroalbuminuria (p < 0.05 vs normoalbuminuric and control subjects [17 +/- 5 beats/min and 1.28 +/- 0.10, respectively]). Similar results were obtained during active standing with respect to change in systolic arterial blood pressure (3 +/- 8, 2 +/- 13 and -6 +/- 11 mmHg; p < 0.05 vs control subjects [8 +/- 11 mmHg]). However, the response of diastolic arterial blood pressure or mean heart rate to standing up did not differ between any of the groups. The ratio of maximum to minimum R-R interval during the dynamic response of heart rate to active standing decreased with the degree of nephropathy (1.27 +/- 0.17, 1.11 +/- 0.11 and 1.05 +/- 0.06) with significantly higher values in patients with normo- compared with patients with macroalbuminuria (p < 0.05). All patients groups had significantly lower values than control subjects (1.46 +/- 0.22, p < 0.05). The overshoot of the blood pressure after an initial fall during active standing decreased with the degree of diabetic nephropathy. In conclusion, type 1 diabetic patients with long duration of diabetes have signs of cardiovascular autonomic neuropathy, the severity of which is related to the degree of nephropathy.     

A harmonious encoding of instrument values by a nineteenth-century Parisian violin dealer

The study of three ledgers from the archives of a prominent Parisian violin maker’s workshop (active from 1796 to 1948) reveals that some of their content was encrypted. Presented here are the deciphering of the code and a discussion of its use in the context of the workshop. Charles-Adolphe Gand introduced this code around 1847 to encrypt values of antique/used violins he would buy and resell. His successors maintained the use of this code at least until 1921. Taking a few examples of instruments by Stradivari and other violin makers, researchers illustrate how the decoded ledgers (listing transactions for more than 2,500 instruments) are of high interest as historical sources documenting the margins, rebates, and commercial practices of these violin dealers. More generally, this article will contribute to better describing the evolution of the market for antique instruments of the violin family.     

Work-related stress and depression among practicing emergency physicians: an international study

STUDY OBJECTIVE: To compare the levels of work-related stress and depression reported by practicing emergency physicians in three survey sites and to determine the effects of gender and marital status on the stress and depression experienced by these physicians. DESIGN: Cross-sectional mail surveys. SETTING AND PARTICIPANTS: Seven hundred sixty-four practicing emergency physicians from the United States, 91 fellows in full-time practice from Australasia, and 154 consultants and 47 senior registrars from the United Kingdom. INTERVENTION: Administration of questionnaires requesting demographic information and including an inventory to assess work-related stress and a scale to measure depressive symptomatology. MEASUREMENTS AND MAIN RESULTS: A 3 x 2 x 2 multivariate analysis of variance performed to compare scores on the stress inventory and depression scale simultaneously by survey site, gender, and marital status revealed significant differences in stress and depression by survey site and marital status. Univariate analyses of variance revealed significant differences in both stress and depression among the three survey sites and in depression by marital status. Adjusted means indicated that physicians from the United Kingdom reported higher levels of stress and depression than physicians from the United States and Australasia. Physicians from the United States and Australasia did not differ with respect to stress or depression. Physicians who were not married reported higher levels of depression than married physicians. No large mean differences, actual or adjusted, were found for any of the grouping factors. CONCLUSION: Statistical differences among practicing emergency physicians from the United States, Australasia, and the United Kingdom were observed, but the actual levels of work-related stress and depression were similar and did not appear severe. Marriage was associated with lower levels of depressive symptomatology.