An improved approach to application-specific power electronicseducation-switch characterization and modeling

An integrated power electronics curriculum has been implemented in the Department of Electrical and Computer Engineering at the University of Illinois, Chicago. This paper describes the development of a set of hands-on laboratory experiments to accompany classroom lectures. Content is based on switching converter topologies and commercial power semiconductor devices. Unlike most experiments, which focus on circuit- or control-level characteristics, our approach emphasizes the circuit-device-load interactions. The concept presented is innovative in that it creates a 3×3 matrix of experiment variation-devices, circuits-control, and machines-loads-with one set of hardware. The lab development is ongoing with future experiments to address three-phase converters and motor control applications. Experiment content is described, as well as the means by which the material has been integrated within the course sequence. Lab station construction and safety issues are also addressed. The experiments require hands-on measurement and circuit connection and complement the established course elements of theory and computer-based circuit modeling. Laboratory experiments and computer simulations collectively provide quantitative evidence of mixed circuit and device optimization     

Monolithic distributed power management for systems-on-Chip (SoC)

With increasing drive towards higher level of integration, lower cost, and longer battery life in wireless applications, there is a need for efficient monolithicdc-dc power converters. This tutorial paper summarizes the topology tradeoffs that are involved in the implementation of monolithic distributed power management in the future generations of SoCs for portable wireless applications. These circuits have a broad range of requirements including high power density, high energy efficiency, low noise, small size, and low cost. The advantages and disadvantages of each of the competing topologies, namely low-dropout linear, switched-capacitor, and switched-modedc-dc converters are examined in light of these requirements.     

Plumbagin-Serum Albumin Interaction: Spectral,Electrochemical, Structure-Binding Analysis,Antiproliferative and Cell Signaling Aspects with Implications for Anticancer Therapy

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a small molecule with potent anticancer activity. Like other 1,4-naphthoquinones, it exhibits electrophilic reactivity towards biological nucleophiles. We demonstrate that plumbagin and structurally related 1,4-naphthoquinones with at least one unsubstituted quinoid carbon (C2 or C3) bind to albumin, an ubiquitously present nucleophile, with minimum recovery of free drug. Extraction recovery of plumbagin from albumin in solution showed one-phase exponential decline with a half-live of 9.3 min at 10 μmol/L. In the presence of albumin, plumbagin exhibited instant changes in UV/Vis absorption bands. Electrochemical analysis using cyclic voltammetry showed a decrease in redox peak currents over time until electro-inactivity, thus suggesting the formation of a supramolecular adduct inaccessible for electron transfer. The adduct inhibited cell growth and caused cell-cycle arrest of prostate cancer cells, in part by decreasing levels of the cell-cycle regulator RBBP. The conjugate displayed similar cellular effects to those described for plumbagin, such as decreased levels of androgen receptor and protein kinase C epsilon. The effect of plumbagin-albumin on cancer cells was species-specific, suggesting a receptor-mediated mechanism. Furthermore, it was blocked by cathepsin inhibitor pepstatin A, indicating that lysosomal degradation is involved in the processing of plumbagin-albumin adduct. The spontaneously formed adduct of plumbagin with serum albumin is likely to mediate the biological activities of plumbagin in vivo and to fundamentally influence its pharmacodynamics.     

A Multistage Interleaved Synchronous Buck Converter With Integrated Output Filter in 0.18 μm SiGe Process

The design and analysis of a fully integrated multistage interleaved synchronous buck dc-dc converter with on-chip filter inductor and capacitor is presented. The dc-dc converter is designed and fabricated in 0.18 mum SiGe RF BiCMOS process technology and generates 1.5 V-2.0 V programmable output voltage supporting a maximum output current of 200 mA. High switching frequency of 45 MHz, multiphase interleaved operation, and fast hysteretic controller reduce the filter inductor and capacitor sizes by two orders of magnitude compared to state-of-the-art converters and enable a fully integrated converter. The fully integrated interleaved converter does not require off-chip decoupling and filtering and enables direct battery connection for integrated applications. This design is the first reported fully integrated multistage interleaved, zero voltage switching synchronous buck converter with monolithic output filters. The fully integrated buck regulator achieves 64% efficiency while providing an output current of 200 mA.