Visual learning and classification of human epithelial type 2 cell images through spontaneous activity patterns

Identifying the presence of anti-nuclear antibody (ANA) in human epithelial type 2 (HEp-2) cells via the indirect immunofluorescence (IIF) protocol is commonly used to diagnose various connective tissue diseases in clinical pathology tests. As it is a labour and time intensive diagnostic process, several computer aided diagnostic (CAD) systems have been proposed. However, the existing CAD systems suffer from numerous shortcomings due to the selection of features, which is commonly based on expert experience. Such a choice of features may not work well when the CAD systems are retasked to another dataset. To address this, in our previous work, we proposed a novel approach that learns a set of filters from HEp-2 cell images. It is inspired by the receptive fields in the mammalian's vision system, since the receptive fields can be thought as a set of filters for similar shapes. We obtain robust filters for HEp-2 cell classification by employing the independent component analysis (ICA) framework. Although, this approach may be held back due to one particular problem; ICA learning requires a sufficiently large volume of training data which is not always available. In this paper, we demonstrate a biologically inspired solution to address this issue via the use of spontaneous activity patterns (SAP). The spontaneous activity patterns, which are related to the spontaneous neural activities initialised by the chemical release in the brain, are found as the typical stimuli for the visual cell development of newborn animals. In the classification system for HEp-2 cells, we propose to model SAP as a set of small image patches containing randomly positioned Gaussian spots. The SAP image patches are generated and mixed with the training images in order to learn filters via the ICA framework. The obtained filters are adopted to extract the set of responses from a HEp-2 cell image. We then employ regions from this set of responses and stack them into “cubic regions”, and apply a classification based on the correlation information of the features. We show that applying the additional SAP leads to a better classification performance on HEp-2 cell images compared to using only the existing patterns for training ICA filters. The improvement on classification is particularly significant when there are not enough specimen images available in the training set, as SAP adds more variations to the existing data that makes the learned ICA model more robust. We show that the proposed approach consistently outperforms three recently proposed CAD systems on two publicly available datasets: ICPR HEp-2 contest and SNPHEp-2.     

Multi expression programming: a new approach to formulation of soil classification

This paper presents an alternative approach to formulation of soil classification by means of a promising variant of genetic programming (GP), namely multi expression programming (MEP). Properties of soil, namely plastic limit, liquid limit, color of soil, percentages of gravel, sand, and fine-grained particles are used as input variables to predict the classification of soils. The models are developed using a reliable database obtained from the previously published literature. The results demonstrate that the MEP-based formulas are able to predict the target values to high degree of accuracy. The MEP-based formulation results are found to be more accurate compared with numerical and analytical results obtained by other researchers.     

Multi-stage genetic programming: A new strategy to nonlinear system modeling

This paper presents a new multi-stage genetic programming (MSGP) strategy for modeling nonlinear systems. The proposed strategy is based on incorporating the individual effect of predictor variables and the interactions among them to provide more accurate simulations. According to the MSGP strategy, an efficient formulation for a problem comprises different terms. In the first stage of the MSGP-based analysis, the output variable is formulated in terms of an influencing variable. Thereafter, the error between the actual and the predicted value is formulated in terms of a new variable. Finally, the interaction term is derived by formulating the difference between the actual values and the values predicted by the individually developed terms. The capabilities of MSGP are illustrated by applying it to the formulation of different complex engineering problems. The problems analyzed herein include the following: (i) simulation of pH neutralization process, (ii) prediction of surface roughness in end milling, and (iii) classification of soil liquefaction conditions. The validity of the proposed strategy is confirmed by applying the derived models to the parts of the experimental results that were not included in the analyses. Further, the external validation of the models is verified using several statistical criteria recommended by other researchers. The MSGP-based solutions are capable of effectively simulating the nonlinear behavior of the investigated systems. The results of MSGP are found to be more accurate than those of standard GP and artificial neural network-based models.     

Distributed learning environments

Distributed learning is an instructional model that gives students access to a wide range of resources-teachers, peers, and content such as readings and exercises - independently of place and time. The popularity of distributed learning environments (DLEs) in both professional and academic settings has steadily increased due to 1) the rising demand from traditional students as well as working adults for postsecondary and professional education, 2) advances in information technologies, 3) the Internet's ubiquity, 4) the emergence of high-capacity wire and wireless networks, and 4) the pervasiveness of networked personal computers in both businesses and homes. DLEs must balance with student attributes and instructional strategies. Many universities and colleges, for-profit organizations, and corporate training departments now offer DLE courses and programs. Online distributed learning uses information technologies to provide students with Web-based access to content and resources such as assignments, software simulations, and tests exercises. This approach lets students choose the time, pace, and frequency of their learning activities.     

Design equations for prediction of pressuremeter soil deformation moduli utilizing expression programming systems

Providing precise estimations of soil deformation modulus is very difficult due to its dependence on many factors. In this study, gene expression programming (GEP) and multi-expression programming (MEP) systems are presented to derive empirical equations for the prediction of the pressuremeter soil deformation modulus. The employed expression programming (EP) systems formulate the soil deformation modulus in terms of the soil physical properties. Selection of the best models is on the basis of developing and controlling several models with different combinations of the affecting parameters. The proposed EP-based models are established upon 114 pressuremeter tests on different soil types conducted in this study. The generalization capabilities of the models are verified using several statistical criteria. Contributions of the variables influencing the soil modulus are evaluated through a sensitivity analysis. The GEP and MEP approaches accurately characterize the soil deformation modulus resulting in a very good prediction performance. The result indicates that moisture content and soil dry unit weight can efficiently represent the initial state and consolidation history of soil for determining its modulus.     

Starch,Sucrose, and Rezol® IL800 as Density Modifiers for Polyurethane Rigid Foams Formulated by Recycled Polyol

Waste polyurethane rigid foam (PUF) is recycled by the glycolysis process. The recycled product is used in a polyol blend, applied in a new foam formulation. Polyurethane rigid foams formulated by recycled polyols are highly dense compared to rigid foams formulated by virgin polyols. As these foams are mostly used in insulation, they make an extra mass to the main product or system that is insulated. Therefore, it is important to decrease their density as much as possible.

Some density modifiers such as starch, sucrose, and REZOL^® IL800 were investigated to recognize their effect on PUF's density.