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Albena Momchilova Roumen Pankov Alexander Alexandrov Tania Markovska Stefan Pankov Plamen Krastev Galya Staneva Evgenia Vassileva Nikolai Krastev Adriana Pinkas 《International journal of molecular sciences》2022,23(14)
Multiple sclerosis (MS) is an autoimmune, inflammatory, degenerative disease of the central nervous system. Changes in lipid metabolism have been suggested to play important roles in MS pathophysiology and progression. In this work we analyzed the lipid composition and sphingolipid-catabolizing enzymes in erythrocytes and plasma from MS patients and healthy controls. We observed reduction of sphingomyelin (SM) and elevation of its products—ceramide (CER) and shingosine (SPH). These changes were supported by the detected up-regulation of the activity of acid sphingomyelinase (ASM) in MS plasma and alkaline ceramidase (ALCER) in erythrocytes from MS patients. In addition, Western blot analysis showed elevated expression of ASM, but not of ALCER. We also compared the ratios between saturated (SAT), unsaturated (UNSAT) and polyunsaturated fatty acids and suggest, based on the significant differences observed for this ratio, that the UNSAT/SAT values could serve as a marker distinguishing erythrocytes and plasma of MS from controls. In conclusion, the application of lipid analysis in the medical practice would contribute to definition of more precise diagnosis, analysis of disease progression, and evaluation of therapeutic strategies. Based on the molecular changes of blood lipids in neurodegenerative pathologies, including MS, clinical lipidomic analytical approaches could become a promising contemporary tool for personalized medicine. 相似文献
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Ambuj Kumar Albena Mihovska Sofoklis Kyriazakos Ramjee Prasad 《Wireless Personal Communications》2014,78(3):1699-1717
With the advent of high efficacy light emitting diode directional lamps as a key component in focal lighting, new possibilities emerge for re-designing the smart home scenario. A smart home scenario is characterized by enabled intelligent interworking of various wireless and wired technologies to provide inhabitants with ease of use of appliances, while creating a personalized and safe ambience space. More and more high and low data rate circulates within the indoor ambient space (e.g., home, hospitals, offices). Although, unlicensed technologies, such as wireless local area networks can take upon part of the indoor traffic, the ever increasing demand for such data, and users, calls for either use of licensed or novel unlicensed wireless communication technologies as part of the smart home enablers. This paper focuses on the potentials of visible light communications (VLCs), jointly with radio and fiber communications, to support very dense low and high data rate connectivity, while enabling deployment of secure-sensitive indoor applications, including indoor tracking and localization. The paper proposes a scenario for integrating VLC into the smart home scenario and a conceptual supporting architecture for its deployment. Further, the technical challenges and possible roadmap for the actual deployment are analyzed for the particular case of an eHealth scenario where the utilization of VLC technology is the enabler of the cost-efficient rollout of the required infrastructure and thus the game-changer in a multi-billion eHealth niche that is seeking for cost affordable solutions. 相似文献
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Leopold Jirovetz Gerhard Buchbauer Albena S. Stoyanova Evgenii V. Georgiev & Stanka T. Damianova 《International Journal of Food Science & Technology》2005,40(3):305-310
The essential oil of seeds of cumin (Cuminum cyminum L.) from Bulgaria stored for more than 35 years was analyzed by physicochemical methods, GC, GC‐MS and olfactometry and its antimicrobial activity tested using different strains of microorganisms. More than sixty constituents of this cumin oil could be identified as essential volatiles, responsible for the pleasant fresh, clean, spicy (typical cumin‐like) odour of a high quality product. Cumin aldehyde (36%), β‐pinene (19.3%), p‐cymene (18.4%) and γ‐terpinene (15.3%) were the principal compounds found. Antimicrobial testing showed high activity of the essential C. cyminum oil against the mold Aspergillus niger, the Gram (+) bacteria Bacillus subtilis and Staphylococcus epidermidis as well as the yeast Saccharomyces cerevisiae and Candida albicans. 相似文献
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Albena Bachvarova-Nedelcheva Reni Iordanova Yanko Dimitriev Elena Kashchieva 《Journal of Materials Science》2007,42(10):3378-3382
The aim of the present investigation is to establish the appropriate routе of nanoparticles formation during heat treatment
of selected selenite glasses. Multicomponent compositions containing SeO2, V2O5, TeO2, MoO3, ZnO and Ag2O have been selected. Different preparation methods of the initial glass samples have been combined with heat treatment to
influence the glass microstructure and formation of different types of microheterogeneites. TEM and SEM have been used to
prove the formation of nanosized particles, randomly distributed in the amorphous matrix volume. Samples containing above
50 wt% Ag2O show the formation of elementary silver with an average particle size of 50–100 nm. Glass-ceramic materials have been obtained
after a long thermal treatment. The main crystal phases detected are Ag2SeO3, Ag2TeO3 and TeO2. 相似文献
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Calabrese V Bates TE Mancuso C Cornelius C Ventimiglia B Cambria MT Di Renzo L De Lorenzo A Dinkova-Kostova AT 《Molecular nutrition & food research》2008,52(9):1062-1073
Free radicals play a main pathogenic role in several human diseases such as neurodegenerative disorders, diabetes, and cancer. Although there has been progress in treatment of these diseases, the development of important side effects may complicate the therapeutic course. Curcumin, a well known spice commonly used in India to make foods colored and flavored, is also used in traditional medicine to treat mild or moderate human diseases. In the recent years, a growing body of literature has unraveled the antioxidant, anticarcinogenic, and antinfectious activity of curcumin based on the ability of this compound to regulate a number of cellular signal transduction pathways. These promising data obtained in vitro are now being translated to the clinic and more than ten clinical trials are currently ongoing worldwide. This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases. 相似文献
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Doris Pospiech Andreas Korwitz Kathrin Eckstein Hartmut Komber Dieter Jehnichen Marcus Suckow Albena Lederer Kerstin Arnhold Michael Göbel Martina Bremer Anton Hoffmann Steffen Fischer Anett Werner Thomas Walther Harald Brünig Brigitte Voit 《应用聚合物科学杂志》2019,136(46):48257
Thermotropic liquid crystalline polyesters with varied chemical structure are synthesized by melt transesterification polycondensation. They are employed as matrix for blends with lignin materials to obtain melt-spinnable precursors for carbon fibers. The lignin samples are carefully purified by fractionation, enzymatic removal of reducing sugars, and subsequent modification of the terminal OH groups. Effective melt blending is achieved with liquid-crystalline aromatic–aliphatic polyesters having melting ranges that match the softening temperature of the lignin fractions, which is necessary to prevent thermal decomposition of the lignin. Polyester/lignin blends are partially compatibilized, phase-separated materials. The polyester/lignin materials are melt-spun successfully. The fiber properties depend on the lignin purification process. X-ray scattering reveals that orientation in lignin-containing fibers is maintained. First experiments show that the fibers can be converted successfully to carbon fibers by thermal annealing procedures. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 48257. 相似文献
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Silvia Moreno Priyanka Sharan Johanna Engelke Hannes Gumz Susanne Boye Ulrich Oertel Peng Wang Susanta Banerjee Rafal Klajn Brigitte Voit Albena Lederer Dietmar Appelhans 《Small (Weinheim an der Bergstrasse, Germany)》2020,16(37)
Temporal activation of biological processes by visible light and subsequent return to an inactive state in the absence of light is an essential characteristic of photoreceptor cells. Inspired by these phenomena, light‐responsive materials are very attractive due to the high spatiotemporal control of light irradiation, with light being able to precisely orchestrate processes repeatedly over many cycles. Herein, it is reported that light‐driven proton transfer triggered by a merocyanine‐based photoacid can be used to modulate the permeability of pH‐responsive polymersomes through cyclic, temporally controlled protonation and deprotonation of the polymersome membrane. The membranes can undergo repeated light‐driven swelling–contraction cycles without losing functional effectiveness. When applied to enzyme loaded‐nanoreactors, this membrane responsiveness is used for the reversible control of enzymatic reactions. This combination of the merocyanine‐based photoacid and pH‐switchable nanoreactors results in rapidly responding and versatile supramolecular systems successfully used to switch enzymatic reactions ON and OFF on demand. 相似文献
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