A Vicenary Analysis of SARS-CoV-2 Genomes

Coronaviruses are responsible for various diseases ranging from the common cold to severe infections like the Middle East syndromes and the severe acute respiratory syndrome. However, a new coronavirus strain known as COVID-19 developed into a pandemic resulting in an ongoing global public health crisis. Therefore, there is a need to understand the genomic transformations that occur within this family of viruses in order to limit disease spread and develop new therapeutic targets. The nucleotide sequences of SARS-CoV-2 are consist of several bases. These bases can be classified into purines and pyrimidines according to their chemical composition. Purines include adenine (A) and guanine (G), while pyrimidines include cytosine (C) and tyrosine (T). There is a need to understand the spatial distribution of these bases on the nucleotide sequence to facilitate the development of antivirals (including neutralizing antibodies) and epitomes necessary for vaccine development. This study aimed to evaluate all the purine and pyrimidine associations within the SARS-CoV-2 genome sequence by measuring mathematical parameters including; Shannon entropy, Hurst exponent, and the nucleotide guanine-cytosine content. The Shannon entropy is used to identify closely associated sequences. Whereas Hurst exponent is used to identifying the auto-correlation of purine-pyrimidine bases even if their organization differs. Different frequency patterns can be used to determine the distribution of all four proteins and the density of each base. The GC-content is used to understand the stability of the DNA. The relevant genome sequences were extracted from the National Center for Biotechnology Information (NCBI) virus database. Furthermore, the phylogenetic properties of the COVID-19 virus were characterized to compare the closeness of the COVID-19 virus with other coronaviruses by evaluating the purine and pyrimidine distribution.     

A review on smart home present state and challenges: linked to context-awareness internet of things (IoT)

The smart home is considered as an essential domain in Internet of Things (IoT) applications, it is an interconnected home where all types of things interact with each other via the Internet. This helps to automate the home by making it smart and interconnected. However, at the same time, it raises a great concern of the privacy and security for the users due to its capability to be controlled remotely. Hence, the rapid technologically growth of IoT raises abundant challenges such as how to provide the home users with safe and secure services keeping privacy in the account and how to manage the smart home successfully under the controlled condition to avoid any further secrecy or theft of personal data. A number of the research papers are available to address these critical issues, researchers presented different approaches to overcome these stated issues. This research review will analyze smart home approaches, challenges and will suggest possible solutions for them and illustrate open issues that still need to be addressed.