Understanding and improving the reduced integration of Mindlin shell elements

The reason for looking in some depth at locking of Mindlin shell elements is introduced. A simple example of straight beam locking is examined in detail. The observations about reduced integration that emerge are subsequently unified with some other facts the writer has come across. A simple curved beam element is then formulated and examined under inextensional bending. The performance of this element under reduced integration is predicted for both the ‘undistorted’ and ‘distorted’ configurations (see text) and for a selective-very reduced integration scheme. The previous predictions are then verified through the performance of an 8 node Mindlin shell element in a suitable cylindrical shell test. The paper finally concludes with a set of important observations that so easily could be drawn from such a simple analysis.     

Peptidomimetic–functionalized carbon nanotubes with antitrypsin activity

Water-soluble functionalized carbon nanotubes (CNTs) have been prepared and further conjugated through a stable covalent bond with two peptidomimetics. The structural design of the covalently grafted peptidomimetics to the CNTs is based on their structural similarity with the metabolites of antagonist G of substance P. A variety of analytical spectroscopic methods, in combination with electron microscopy and thermal analysis, aided the structural and morphological characterization of the four newly synthesized peptidomimetic–CNT conjugates. It is demonstrated that the trypsin inhibitory effect of the peptidomimetic–CNT is enhanced as a result of the high-loading of peptidomimetics onto the skeleton of the modified water-soluble CNTs. Additionally, the peptidomimetic–functionalized CNT conjugates can be recovered and re-employed up to six biological evaluation cycles showing the same trypsin inhibitory activity. Such a nanosized system is extremely advantageous for the inhibition of inflammation or malignancy and could find potential future biological applications in the area of drug delivery systems.     

Key factors to improve the efficiency of roll-to-roll printed organic photovoltaics

In order to achieve the cost-efficient scalability of flexible organic photovoltaics (OPVs), the optimization of key factors related to the materials and roll-to-roll (R2R) processes is necessary. The limited drying during the R2R printing process induces a vertical phase separation leading to the formation of a P3HT-rich top region on the photoactive layer which acts as an electron barrier in normal geometry. We show that the increase of R2R drying time and/or post-annealing can enhance the OPV efficiency by the diffusion of PCBM towards the photoactive layer surface forming an electron transport network. It is estimated that the volume fraction of PCBM at the top region of the films triples from about 9% to 30%. In addition, the direct exposure of PEDOT:PSS to air after printing leads to morphological changes that negatively affect the efficiency. Therefore, the protection of PEDOT:PSS from air in combination to the increase of the R2R drying time enables the significant increase of the R2R printed OPVs efficiency to 1%.     

Merging high doxorubicin loading with pronounced magnetic response and bio-repellent properties in hybrid drug nanocarriers

Hybrid magnetic drug nanocarriers are prepared via a self-assembly process of poly(methacrylic acid)-graft-poly(ethyleneglycol methacrylate) (p(MAA-g-EGMA)) on growing iron oxide nanocrystallites. The nanocarriers successfully merge together bio-repellent properties, pronounced magnetic response, and high loading capacity for the potent anticancer drug doxorubicin (adriamicin), in a manner not observed before in such hybrid colloids. High magnetic responses are accomplished by engineering the size of the magnetic nanocrystallites (～13.5 nm) following an aqueous single-ferrous precursor route, and through adjustment of the number of cores in each colloidal assembly. Complementing conventional magnetometry, the magnetic response of the nanocarriers is evaluated by magnetophoretic experiments providing insight into their internal organization and on their response to magnetic manipulation. The structural organization of the graft-copolymer, locked on the surface of the nanocrystallites, is further probed by small-angle neutron scattering on single-core colloids. Analysis showed that the MAA segments selectively populate the area around the magnetic nanocrystallites, while the poly(ethylene glycol)-grafted chains are arranged as protrusions, pointing towards the aqueous environment. These nanocarriers are screened at various pHs and in highly salted media by light scattering and electrokinetic measurements. According to the results, their stability is dramatically enhanced, as compared to uncoated nanocrystallites, owing to the presence of the external protective PEG canopy. The nanocarriers are also endowed with bio-repellent properties, as evidenced by stability assays using human blood plasma as the medium.     

Design,characterisation and drug release study of polymeric,drug‐eluting single layer thin films on the surface of intraocular lenses

To design, develop and study a novel drug delivery system for intraocular applications. The spin coating technique was applied to develop a polymeric, drug‐eluting thin film consisting of a blend of organic polymers [poly (D, L lactide coglycolide) lactide: glycolide 75: 25, PLGA and polycaprolactone, PCL] and dexamethasone on the surface of intraocular lenses (IOLs). The initial durability of the IOLs during spinning was assessed. Information about the structural and optical properties of the modified IOLs was extracted using atomic force microscopy, scanning electron microscopy and spectroscopic ellipsometry. A drug release study was conducted for 8 weeks. The IOLs were durable in spinning speeds higher than the ones used to develop thin films. Single‐layer thin films were successfully developed on the optics and the haptics of the lenses. The films formed nanopores with encapsulated aggregates of dexamethasone. The spectroscopic ellipsometry showed an acceptable optical transparency of the lenses regardless of the deposition of the drug‐eluting films on their surface. The drug release study demonstrated gradual dexamethasone release over the selected period. In conclusion, the novel drug‐eluting IOL system exhibited desired properties regarding its transparency and drug release rate. Further research is necessary to assess their suitability as an intraocular drug delivery system.Inspec keywords: ellipsometry, encapsulation, nanoporous materials, spin coating, polymer blends, biodegradable materials, surface treatment, polymer films, atomic force microscopy, transparency, nanomedicine, durability, scanning electron microscopy, drug delivery systemsOther keywords: drug release, intraocular lenses, intraocular applications, spin coating technique, modified IOLs, spectroscopic ellipsometry, dexamethasone release, transparency, drug release rate, intraocular drug delivery system, drug‐eluting IOL system, polymeric drug‐eluting single‐layer thin films, optical properties, structural properties     

Real-time optical modelling and investigation of inorganic nano-layer growth onto flexible polymeric substrates

A major factor for the achievement of the desirable performance, efficiency and lifetime of flexible organic electronic devices is the optimization of the encapsulation layers that protect the device active layers by atmospheric gas molecule permeation. The active layers consisted of small molecule and/or polymer organic semiconductors as well as the organic conductors need to be encapsulated into a transparent medium that will provide the necessary protection and maintain their charge generation and transport characteristics. The encapsulation layers are generally consisted of inorganic thin films (silicon oxide—SiO_x and aluminium oxide—AlO_x) deposited onto the polymeric substrates, such as PolyEthylene Terephthalate (PET). In this work, in situ and real-time Spectroscopic Ellipsometry in the ultraviolet spectral region has been implemented in order to investigate the growth of inorganic SiO_x and AlO_x nano-layers onto PET flexible polymeric substrates as well as the PET/inorganic interface effects during the early stages of growth. The analysis of the pseudodielectric function <?(ω)> that was measured in real-time in very short time scales (in the order of hundreds of ms) has provided detailed information on the time evolution of the thickness and deposition rate of the inorganic nano-layers during their growth process as well as on their optical and electronic properties. This work proposes a methodology for using real-time optical monitoring technique with the aim to tailor and control the functionality of these materials for application in flexible electronic devices.     

Artificial neural networks used for the performance prediction of a thermosiphon solar water heater

Artificial Neural Networks (ANN) are widely accepted as a technology offering an alternative way to tackle complex and ill-defined problems. They can learn from examples, are fault tolerant, are able to deal with non-linear problems, and once trained can perform prediction at high speed. ANNs have been used in diverse applications and they have shown to be particularly effective in system modelling as well as for system identification. The objective of this work is to train an artificial neural network (ANN) to learn to predict the performance of a thermosiphon solar domestic water heating system. This performance is measured in terms of the useful energy extracted and of the stored water temperature rise. An ANN has been trained using performance data for four types of systems, all employing the same collector panel under varying weather conditions. In this way the network was trained to accept and handle a number of unusual cases. The data presented as input were, the storage tank heat loss coefficient (U-value), the type of system (open or closed), the storage volume, and a total of fifty-four readings from real experiments of total daily solar radiation, total daily diffuse radiation, ambient air temperature, and the water temperature in storage tank at the beginning of the day. The network output is the useful energy extracted from the system and the water temperature rise. The statistical coefficient of multiple determination (R²-value) obtained for the training data set was equal to 0.9914 and 0.9808 for the two output parameters respectively. Both values are satisfactory because the closer R²-value is to unity the better is the mapping. Unknown data for all four systems were subsequently used to investigate the accuracy of prediction. These include performance data for the systems considered for the training of the network at different weather conditions. Predictions with maximum deviations of 1 MJ and 2.2°C were obtained respectively. Random data were also used both with the performance equations obtained from the experimental measurements and with the artificial neural network to predict the above two parameters. The predicted values thus obtained were very comparable. These results indicate that the proposed method can successfully be used for the estimation of the performance of the particular thermosiphon system at any of the different types of configuration used here. The greatest advantage of the present model is the capacity of the network to learn from examples and thus gradually improve its performance. This is done by embedding experimental knowledge in the network.     

Ariane 5 attitude control system passivation: theoretical and experimental determination of the explosion threshold pressure

The Attitude Control System (ACS) of the future European heavy launcher Ariane 5 is a Hydrazine system including two bladder tanks pressurised by Nitrogen ; depending on the mission, a residual pressure of some 10 to 20 bars may still remain at the end of the mission. In order to avoid any debris generation, the explosion threshold pressure has been determined theoretically, then demonstrated experimentally. This pressure is defined by the behaviour of the tank under the impact of a micrometeoroid or a space debris : for pressures above it, the tank explodes ; otherwise, it is simply punctured. A theoretical analysis based on fracture mechanics was led first, showing that the crack propagation would become divergent for pressures in the range of 20 to 25 bars. A series of 2D simulations was then performed in two steps : first the local effect of the impacting particle on the tank wall, which enables the computation of the stress fields in the material ; second, the global propagation of such initial conditions in the complete tank. Several cases were computed, with different particles, impacting at different velocities on tanks with different pressures. The worst case was determined and a test prevision was led. The test was performed with a tank pressurized at 18 bar; the impacting particle was 1 mm diameter Aluminium sphere, launched at a velocity of 9 km/s. The tank did not explode, and the resulting hole was close to the one predicted (3.2 mm in diameter, vs. 3 to 3.5 predicted). The resulting maximal residual pressure specified to the ACS is 15 bar, a 20% margin being selected. With this new requirement, we are confident that no explosion can occur in orbit and that the general debris mitigation rules are fully applied.     

Wine produced by immobilized cells on dried raisin berries in sensory evaluation comparison with commercial products

Comparative sensory evaluation of wines produced by immobilized cells of Uvaferme 299 on dried raisin berries and free cells using the Saint Denis grape variety and of commercial Greek products (‘Biblia Chora’ rosé wine produced from the Syrah grape variety, ‘Palivos’ and ‘Strofilia’ rosé wines both produced from the Agiorgitiko grape variety) was carried out. Sensory evaluation was conducted twice by 11 tasters previously trained and a method for panel validation was proposed. Subsequently, the wines were evaluated for their aroma intension, aroma complexity, aroma elegance and overall quality. Duncan's multiple range test clearly showed that there were statistically significant differences between wines produced using different grape varieties and fermentation conditions. Linear regression analysis of the results was performed in order to investigate which sensory parameter had a significant effect on the overall quality and it revealed that only aroma elegance affected significantly the overall quality. Wine produced by immobilized cells scored a statistically higher value for its overall quality than the wine produced by free cells. Finally, discriminant sensory evaluation revealed a gooseberry, cherry, mint aroma for ‘Biblia Chora’ wine and a citrus, rose aroma for ‘Strofilia’ and ‘Palivos’ wines. Wines produced using immobilized and free cells were characterized by a fruity, banana‐like aroma, and a herbaceous note was predominant. Copyright © 2005 Society of Chemical Industry     

Surface,interface and electronic properties of F8:F8BT polymeric thin films used for organic light‐emitting diode applications

Ultrathin polymeric films consisting of poly(9,9‐di‐n‐octylfluorenyl‐2,7‐diyl) (F8) blended with poly(9,9‐dioctylfluorene‐alt‐benzothiadiazole) (F8BT) grown onto PEDOT:PSS/ITO/PET were investigated by X‐ray photoelectron spectroscopy (XPS), depth‐profiling XPS, reflection electron energy loss spectroscopy (REELS) and angle‐dependent X‐ray absorption spectroscopy (XAS) to gain information on the films' electronic, order and interface properties. AFM studies provide valuable information on the films' nanotopographical properties and homogeneity. Spectroscopic ellipsometry and photoluminescence spectroscopy were used also to obtain information on the optoelectronic properties. Well‐ordered films were observed from the XAS analysis, measured at the sulfur K absorption edge. XPS measurements demonstrated that the surface composition of the polymer thin films prepared by a spin‐coating wet‐chemical deposition method matches the expected F8:F8BT blend stoichiometry. The interfacial properties were studied through an argon ion sputtering process coupled to the XPS acquisition, showing an enhancement of oxygen components at the interface. The films' inhomogeneity was verified by AFM images and analysis. We obtained a value of 3.1 eV as the electronic bandgap of the F8:F8BT film from REELS data, whereas analysis of the spectroscopic ellipsometry spectra revealed that the optical bandgap of F8:F8BT has a value of 2.4 eV. A strong green emission was obtained for the produced films, which is in agreement with the expected emission due to the 1:19 ratio of the F8 and F8BT blended polymers. © 2018 Society of Chemical Industry