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排序方式: 共有219条查询结果,搜索用时 15 毫秒
1.
J. J. Biernacki J. M. Richardson P. E. Stutzman D. P. Bentz 《Journal of the American Ceramic Society》2002,85(9):2261-2267
The reaction between ground granulated blast furnace slag (GGBFS) having an empirical formula of C7.88 S7.39 M3 A and calcium hydroxide (CH) was investigated. The kinetics of the reaction were explored. Thermogravimetric analysis was used to monitor the consumption of CH from which rate constants were determined. Based on Knudsen's kinetic model, activation energies of 14.5, 17.9, and 22.6 kJ/mol were determined for three different mass ratios of slag and CH reacted over a temperature range of 15° to 50°C and hydrated for a period of time from 0 to 32 days. A comparison of the kinetics of the slag/CH reaction was made with slag/portland cement hydration. The basic features of both appear similar. 相似文献
2.
Agnieszka Drd Adrianna Sawiska-Brych Dominika Kubera Magdalena Kimsa-Dudek Joanna Magdalena Gola Jolanta Adamska Celina Kruszniewska-Rajs Arkadiusz Matwijczuk Dariusz Karcz Wojciech Dbrowski Andrzej Stepulak Mariusz Gago 《International journal of molecular sciences》2022,23(23)
4-(5-methyl-1,3,4-thiadiazole-2-yl) benzene-1,3-diol (C1) and 4-[5-(naphthalen-1-ylmethyl)-1,3,4-thiadiazol-2-yl] benzene1,3-diol (NTBD) are representative derivatives of the thiadiazole group, with a high antimycotic potential and minimal toxicity against normal human fibroblast cells. The present study has proved its ability to synergize with the antifungal activity of AmB. The aim of this work was to evaluate the cytotoxic effects of C1 or NTBD, alone or in combination with AmB, on human renal proximal tubule epithelial cells (RPTECs) in vitro. Cell viability was assessed with the MTT assay. Flow cytometry and spectrofluorimetric techniques were used to assess the type of cell death and production of reactive oxygen species (ROS), respectively. The ELISA assay was performed to measure the caspase-2, -3, and -9 activity. ATR-FTIR spectroscopy was used to evaluate biomolecular changes in RPTECs induced by the tested formulas. The combinations of C1/NTBD and AmB did not exert a strong inhibitory effect on the viability/growth of kidney cells, as evidenced by the negligible changes in the apoptotic/necrotic rate and caspase activity, compared to the control cells. Both NTBD and C1 displayed stronger anti-oxidant activity when combined with AmB. The relatively low nephrotoxicity of the thiadiazole derivative combinations and the protective activity against AmB-induced oxidative stress may indicate their potential use in the therapy of fungal infections. 相似文献
3.
Aleksandra Obuchowska Kamila Gorczyca Arkadiusz Standyo Karolina Obuchowska aneta Kimber-Trojnar Magdalena Wierzchowska-Opoka Boena Leszczyska-Gorzelak 《International journal of molecular sciences》2022,23(15)
Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a “window” to the mother’s future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother’s future. 相似文献
4.
Miniaturisation and simplification are novel approaches in clinical bioanalysis, especially in therapeutic drug monitoring (TDM). These contemporary trends are related to the sampling, pre-treatment, and analysis of biological fluids. Currently, dried blood spot (DBS), one of the most popular microsampling techniques, is feasible and inexpensive. However, obtaining reliable results with sample homogeneity and volume variability is difficult. Volumetric Absorptive Microsampling (VAMS) has recently enabled the accurate and precise collection of a fixed blood volume. It reduced the hematocrit effect, improved volumetric accuracy, and generated results correlating with the dose and drug exposure from wet blood. This review focuses on VAMS-Mitra™ devices, which have become increasingly important since 2014, mainly for TDM and toxicology studies. First, the current literature has been reviewed based on immunosuppressants and their determination in samples obtained using Mitra™. Second, the critical points, weaknesses, and strengths have been characterized in contrast to classic venipuncture and other microsampling methods. Finally, we indicate the points of attention according to the perspective of Mitra™ as well as its usefulness in clinical practice. VAMS is currently state-of-the-art in microsampling and seems to be a good instrument for improving adherence to immunosuppressive therapy, especially in the pediatric population. 相似文献
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The Impact of Linseed Oil Lipids on the Physical Properties of Corn Crisps and the Possibility of Obtaining Crisps Enriched with n‐3 Fatty Acids 下载免费PDF全文
Arkadiusz Szterk Mateusz Rogalski Tomasz Szymborski 《Journal of the American Oil Chemists' Society》2015,92(8):1195-1203
Linseed oil, also known as flaxseed oil, is obtained from the dried, ripened seeds of the flax plant (Linum usitatissimum). The oil is obtained by pressing, sometimes followed by solvent extraction supported by a refining process. Linseed oil is an edible oil that is in demand as a nutritional supplement, as a source of α‐linolenic acid an n‐3 fatty acid. The aim of this work was to investigate: (1) the influence of the corn crisp extrusion process on the degradation of fatty acids in linseed oil (LO) and some preparations obtained from the linseed oil such as ethyl ester (EE) and free fatty acids (FFA) added to the corn in order to increase the nutritional value of the crisps, (2) influence of the oil and two fatty preparations obtained from it on the quality of corn crisps, (3) interaction of the lipid fraction with starch. The extrusion process did not degrade the fatty acids significantly. Expansion ratio obtained in the corn crisp extrusion process decreased from 620 % down to 153 %, the size of pores/thickness of the starch–protein walls forming the structure of the extruded product decreased from 10 μm down to 4 μm, the hardness of the crisps increased from 20 to 75 N, and number of lipid–starch complexes increased with rising polarity of the lipid fraction. FFA were complexed mostly by starch (about 90 %), to a lesser degree by EE (about 60 %) and to the least extent by triacylglycerols (about 10 %). The studies performed under industrial conditions using the single screw extruder for the production of corn crisps with the application of standard parameters of the extrusion process indicated that the addition of a mass of 5 % of the various lipids (triacylglycerols of linseed oil, ethyl esters and fatty acids obtained from linseed oil) to corn grits prior to the extrusion process significantly affect the quality of corn crisps. 相似文献
8.
Nonisothermal crystallization kinetics of highly‐filled polyolefin composites was studied by means of differential scanning calorimetry (DSC). Two types of commercial calcium carbonate based fillers (modified with stearic acid and nonmodified one) were used for our investigations. In order to evaluate the crystallization kinetics changes of composites, the Avrami theory modified by Jeziorny was used. Validity of mineral fillers modification with stearic acid has been proved by thermal analysis. Because of the suppression of the heterogeneous nucleation effect resulting from calcium carbonate with stearic acid modification, an increase in the processability of highly‐filled polyolefin cast films might occur. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 41201. 相似文献
9.
Factor analysis is a powerful tool used for the analysis of dynamic studies. One of the major drawbacks of factor analysis of dynamic structures (FADS) is that the solution is not mathematically unique when only nonnegativity constraints are used to determine factors and factor coefficients. In this paper, a method to correct for ambiguous FADS solutions has been developed. A nonambiguous solution (to within certain scaling factors) is obtained by constructing and minimizing a new objective function. The most common objective function consists of a least squares term that when minimized with nonnegativity constraints, forces agreement between the applied factor model and the measured data. In our method, this objective function is modified by adding a term that penalizes multiple components in the images of the factor coefficients. Due to nonuniqueness effects, these factor coefficients consist of more than one physiological component. The technique was tested on computer simulations, an experimental canine cardiac study using 99mTc-teboroxime, and a patient planar 99mTc-MAG3 renal study. The results show that the technique works well in comparison to the truth in computer simulations and to region of interest (ROI) measurements in the experimental studies. 相似文献