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排序方式: 共有106条查询结果,搜索用时 15 毫秒
1.
Bilal Alashkar Alhamwe Daniel P. Potaczek Sarah Miethe Fahd Alhamdan Lukas Hintz Arslan Magomedov Holger Garn 《International journal of molecular sciences》2021,22(9)
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma. 相似文献
2.
M. N. Magomedov 《Technical Physics Letters》2002,28(5):430-433
Expressions for the calculation of the parameters of self-diffusion in a crystal of simple substance at temperatures close
to absolute zero are derived. It is established that, in “loose” crystal structures (with the first coordination number below
12), the amount of atoms involved in diffusion motion exceeds the number of vacant sites in the crystal lattice at T=0 K. The results of calculations of the vacancy and diffusion parameters at T=0 K for ten cryocrystals show that the phenomenon of “nonvacancy self-diffusion at T=0 K” can take place only in bcc helium. 相似文献
3.
A. S. Vorob'ev Z. A. Magomedov A. A. Onishchenko 《Power Technology and Engineering (formerly Hydrotechnical Construction)》1989,23(8):467-470
1. | Intense passage of the sediment deposits washed from the upstream stretches of the reservoir through the cut was observed. In the cut itself or in the immediate vicinity of its outlet, 13,000 m3 of sediments was deposited, the remainder was discharged by the through-flow into the downstream pool. |
2. | The cut made was not curvilinear in plan as was intended, and therefore its expected intensive erosion by the flow did not occur. The exception was the inlet stretch of the cut, where its erosion and widening by about 10 m occurred. |
3. | An increase of the cross-sectional area of the reservoir due to the cut leads to some decrease of the level of the flushing flow in the main channel and increases its slope on the upstream stretch of the reservoir, increasing the flow velocity and effectiveness of erosion of the sediments. Furthermore, the directions of the flow velocities partially changed in the region of the cut, which intensified the effect of erosion of the sediments. |
4. | Gradual erosion of the island of sediment deposits cut off by the cut from the left-bank mass of sediments was observed during flushing and subsequent operation of the reservoir. |
5. | It is better to use diesel dredges for making cuts, which, with their self-contained power supply makes it possible to operate on any stretch of the reservoir at a sufficient distance from the bank. |
6. | The cost effectiveness of combined removal of sediments can be estimated by comparing the cost of conducting it with the cost of removing sediments by hydraulicking as the cheapest of the presently known methods. For conditions of the Chiryurt reservoir the effectiveness was 0.9 ruble/m3 of sediments being removed for the particular flushing under consideration. |
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6.
M. N. Magomedov 《Technical Physics Letters》2013,39(5):409-412
A model of nanocrystal in the form of a rectangular parallelepiped with a variable surface shape is used to show that, at high temperatures, modulus of elasticity B decreases with a decrease in size of the nanocrystal N, which is due to the increase in the surface pressure. However, at low temperatures, dependence B(N) is less pronounced and can even rise with a decrease in the nanocrystal size. This is because, at low temperatures, the increase in the surface pressure (which is larger than at high temperatures) leads to an increase in the modulus of elasticity for the entire nanocrystal. The more the nanocrystal shape deviates from the most energetically stable shape, the more pronounced the change in the dependence B(N) is. 相似文献
7.
M. N. Magomedov 《High Temperature》2002,40(4):542-545
Equations are obtained which must be satisfied by the temperature dependence of the Debye temperature ((T)) so that the thermodynamic functions calculated on its basis would satisfy both the third principle of thermodynamics and the law of equipartition of energy over degrees of freedom. A general expression for the function (T) is obtained, which satisfies these thermodynamic regularities. 相似文献
8.
The P systems (or membrane systems) are a class of distributed parallel computing devices of a biochemical type, where membrane division is the frequently investigated way for obtaining an exponential working space in a linear time, and on this basis solving hard problems, typically NP-complete problems, in polynomial (often, linear) time. In this paper, using another way to obtain exponential working space – membrane separation, it was shown that Satisfiability Problem and Hamiltonian Path Problem can be deterministically solved in linear or polynomial time by a uniform family of P systems with separation rules, where separation rules are not changing labels, but polarizations are used. Some related open problems are mentioned. 相似文献
9.
We investigate the computational power of energy-based P systems, a model of membrane systems, where a fixed amount of energy is associated with each object and the rules transform single objects by adding or removing energy from them. We answer the recently proposed open questions about the power of such systems without priorities associated with the rules, for both sequential and maximally parallel modes. We also conjecture that deterministic energy-based P systems are not computationally complete. 相似文献
10.
M. N. Magomedov 《Inorganic Materials》2010,46(11):1181-1185
Correlations of potential parameters with the atomic weight are used to determine parameters of the interatomic interaction potential for sphalerite-structured AB binary crystals composed of group IVa elements. It is shown that the parameters for elastic (reversible) deformation differ from those for plastic (irreversible) deformation capable of breaking covalent bonds. A calculational procedure is proposed for evaluating the properties of a sphalerite-structured binary crystal consisting of atoms A and B in which the crystal is represented as a diamond-like crystal composed of identical atoms with a mass equal to the harmonic mean of the masses of atoms A and B. The calculated properties of β-SiC and GeSi agree well with earlier estimates. Predictions of properties are presented for other binary crystals of the group IVa elements whose properties have not been reported in the literature. 相似文献