Mammalian Exocrine Secretions. XVIII: Chemical Characterization of Interdigital Secretion of Red Hartebeest, Alcelaphus buselaphus caama

Gas chromatography, coupled gas chromatography-mass spectrometry (electron impact mode and chemical ionization with methane as reactant gas), gas chromatography-infrared spectroscopy, and derivatization techniques were used to identity 53 compounds in the interdigital secretion of the red hartebeest, Alcelaphus buselaphus caama. These compounds included alkanes, isoalkanes, alcohols, ketones, carboxylic acids, oxiranes, furanoid linalool oxides, and a large number of branched and unbranched saturated and unsaturated aldehydes. The secretion probably plays a role in demarcation of territories by dominant bulls.     

Partial correction for turbulent distortions in telescopes

To provide complete compensation for turbulent distortions in the visible range at aperture dimensions typical for modern telescopes (6-10 m), one needs to develop adaptive systems with hundreds of control channels. More simple adaptive systems that provide complete compensation in the infrared range can give an essential advantage in angular resolution in the visible range too. In this case the image brightness characterized by the Strehl ratio remains much less than that in the diffraction-limited case, i.e., the system provides only partial compensation. We present the results of numerical calculations of the partially corrected point-spread function and discuss possible approaches to composing the adaptive system configuration.     

Modeling the Wavelength Dependence of the Index of Refraction of Water in the Range 200 nm to 200 mum

We modeled the index of refraction of water at a temperature of25 degrees C, employing a Lorentz model for wavelengths ranging from 200 nmto 200 mum. We determined model parameters by minimizingdiscrepancies between calculated and experimental data, using an elitegenetic algorithm with adaptive mutations. We found that a Lorentzmodel with six oscillators fits the available data well in the wholerange of interest.     

Multiple circular-harmonic-function correlation filter providing specified response to in-plane rotation

The circular-harmonic-function correlation filter originally proposed by Hsu and Arsenault [Appl. Opt. 21, 4016 (1982)] for in-plane rotation invariance uses only one harmonic, which results in poor discrimination capability of the filter. Various methods to use multiple harmonics were explored previously by different researchers. We present a new method to combine multiple circular harmonics into a single filter that can provide the desired correlation response to in-plane rotation while minimizing the correlation-plane energy. Since multiple harmonics are included, the filter can discriminate well, and since correlation-plane energy is minimized, correlation peaks tend to be sharp. Since the designer can specify the desired in-plane rotation response, a variety of filter behaviors (including complete invariance to input rotations) can be obtained. Underlying theory is discussed, and simulation results are presented.     

Wide-angle stray-light reduction for a spaceborne optical hemispherical imager

We describe a simple visible-light stray-background-reducing baffle, suitable for use on a stabilized interplanetary platform. The design is a corrallike enclosure with five concentric walls. The baffle reduces direct sunlight and reflections from illuminated portions of the spacecraft by a factor of 10(-12), provided that all these lie beyond at least a hemisphere centered on the viewing aperture. With this condition these bright sources do not directly illuminate within the outermost wall of the corral, and diffraction over the wall tops is the dominant mechanism by which light reaches the corral interior. We present design calculations for such a corral, as well as a laboratory measurement confirming the basic design assumption.     

A bayesian approach to deformed pattern matching of iris images

We describe a general probabilistic framework for matching patterns that experience in-plane nonlinear deformations, such as iris patterns. Given a pair of images, we derive a maximum a posteriori probability (MAP) estimate of the parameters of the relative deformation between them. Our estimation process accomplishes two things simultaneously: it normalizes for pattern warping and it returns a distortion-tolerant similarity metric which can be used for matching two nonlinearly deformed image patterns. The prior probability of the deformation parameters is specific to the pattern-type and, therefore, should result in more accurate matching than an arbitrary general distribution. We show that the proposed method is very well suited for handling iris biometrics, applying it to two databases of iris images which contain real instances of warped patterns. We demonstrate a significant improvement in matching accuracy using the proposed deformed Bayesian matching methodology. We also show that the additional computation required to estimate the deformation is relatively inexpensive, making it suitable for real-time applications     

Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates

Concurrent inhibition of aromatase and steroid sulfatase (STS) may provide a more effective treatment for hormone‐dependent breast cancer than monotherapy against individual enzymes, and several dual aromatase–sulfatase inhibitors (DASIs) have been reported. Three aromatase inhibitors with sub‐nanomolar potency, better than the benchmark agent letrozole, were designed. To further explore the DASI concept, a new series of letrozole‐derived sulfamates and a vorozole‐based sulfamate were designed and biologically evaluated in JEG‐3 cells to reveal structure–activity relationships. Amongst achiral and racemic compounds, 2‐bromo‐4‐(2‐(4‐cyanophenyl)‐2‐(1H‐1,2,4‐triazol‐1‐yl)ethyl)phenyl sulfamate is the most potent DASI (aromatase: IC₅₀=0.87 nM ; STS: IC₅₀=593 nM ). The enantiomers of the phenolic precursor to this compound were separated by chiral HPLC and their absolute configuration determined by X‐ray crystallography. Following conversion to their corresponding sulfamates, the S‐(+)‐enantiomer was found to inhibit aromatase and sulfatase most potently (aromatase: IC₅₀=0.52 nM ; STS: IC₅₀=280 nM ). The docking of each enantiomer and other ligands into the aromatase and sulfatase active sites was also investigated.     

Electrochemical oxidation of chlorophenols at a boron-doped diamond electrode and their determination by high-performance liquid chromatography with amperometric detection

Anodically pretreated diamond electrodes have been used for the detection of chlorophenols (CPs) in environmental water samples after high-performance liquid chromatographic (HPLC) separation. The anodization of as-deposited boron-doped polycrystalline diamond thin-film electrodes has enabled the stable determination of phenols over a wide concentration range. Prior to the HPLC analysis, a comparative study with ordinary glassy carbon, as-deposited diamond, and anodized diamond was made to examine the oxidative behavior of phenols by cyclic voltammety and flow injection analysis with amperometric detection. At anodized diamond electrodes, reproducible, well-defined cyclic voltammograms were obtained even at high CP concentration (5 mM), due to a low proclivity for adsorption of the oxidation products on the surface. In addition, after prolonged use, the partially deactivated diamond could be reactivated on line by applying a highly anodic potential (2.64 Vvs SCE) for 4 min, which enabled the destruction of the electrodeposited polymer deposits. Hydroxyl radicals produced by the high applied potential, in which oxygen evolution occurs, are believed to be responsible for the oxidation of the passivating layer on the surface. When coupled with flow injection analysis (FIA), anodized diamond exhibited excellent stability, with a response variability of 2.3% (n = 100), for the oxidation of a high concentration (5 mM) of chlorophenol. In contrast, glassy carbon exhibited a response variability of 39.1%. After 100 injections, the relative peak intensity, for diamond decreased by 10%, while a drastic decrease of 70% was observed for glassy carbon. The detection limit obtained in the FIA mode for 2,4-dichlorophenol was found to be 20 nM (S/N = 3), with a linear dynamic range up to 100 microM. By coupling with the column-switching technique, which enabled on-line preconcentration (50 times), the detection limit was lowered to 0.4 nM (S/N = 3). By use of this technique, anodized diamond electrodes were demonstrated for the analysis of CPs in drainwater that was condensed from the flue gas of waste incinerators.