A Bioglass-Based Antibiotic (Vancomycin) Releasing Bone Void Filling Putty to Treat Osteomyelitis and Aid Bone Healing

While the infection rate after primary total joint replacements (TJR) sits at 1–2%, for trauma-related surgery, it can be as high as 3.6 to 21.2% based on the type of trauma; the risk of reinfection after revision surgery is even higher. Current treatments with antibiotic-releasing PMMA-based bone cement/ beads and/or systemic antibiotic after surgical debridement do not provide effective treatment due to fluctuating antibiotic levels at the site of infection, leading to insufficient local antibiotic concentration. In addition, non-biodegradable PMMA does not support bone regrowth in the debrided void spaces and often must be removed in an additional surgery. Here, we report a bioactive glass or bioglass (BG) substrate-based biodegradable, easy to fabricate “press fitting” antibiotic-releasing bone void filling (ABVF-BG) putty to provide effective local antibiotic release at the site of infection along with support for bone regeneration. The ABVF-BG putty formulation had homogenously distributed BG particles, a porous structure, and showed putty-like ease of handling. Furthermore, the ABVF-BG putty demonstrated in vitro antibacterial activity for up to 6 weeks. Finally, the ABVF-BG putty was biodegradable in vivo and showed 100% bacterial eradication (as shown by bacterial cell counts) in the treatment group, which received ABVF-BG putty, compared to the infection control group, where all the rats had a high bacterial load (4.63 × 10⁶ ± 7.9 × 10⁵ CFU/gram bone) and sustained osteomyelitis. The ABVF-BG putty also supported bone growth in the void space as indicated by a combination of histology, µCT, and X-ray imaging. The potential for simultaneous infection treatment and bone healing using the developed BG-based ABVF-BG putty is promising as an alternative treatment option for osteomyelitis.     

An Efficient Delay Tolerance and Cost-Effective Secure NFV Enabled Multi-casting in Mobile Edge Cloud Networks

The mobile edge cloud has developed as the main platform to offer low latency network services from the edge of networks for stringent delay necessities of mobile applications. In mobile edge cloud networks, network functions virtualization (NFV) creates the frameworks for building up a new dynamic resource management framework structure to effectively utilize network resources. Delay tolerance NFV-enabled multicast request admissions in a mobile edge-cloud network are explored in this paper to limit request admission delays or maximizing system performance for a group of requests arriving individually. At first, for the cost reduction issue of a single NFV-empowered multicast request admission, the admission cost of each multicast request is assessed, and the Support based graph is constructed. Here, the multicast requests are prioritized dependent on their admission cost. Subsequently, trust and the delay-based local gradient are assessed for the prioritized multicast requests. At long last, delay tolerance NFV multicasting is accomplished by successful (First Come First Serve) FCFS queuing reliant on the assessed local gradient of requests. When compared to existing approaches, the exploratory results show that the proposed methodology is superior in terms of throughput, admission cost, and running time.