Communication and organization: an empirical study of discussion ininspection meetings

This paper describes an empirical study that addresses the issue of communication among members of a software development organization. In particular, data was collected concerning code inspections in one software development project. The question of interest is whether or not organizational structure (the network of relationships between developers) has an effect on the amount of effort expended on communication between developers. The independent variables in this study are various attributes of the organizational structure in which the inspection participants work. The dependent variables are measures of the communication effort expended in various parts of the code inspection process, focusing on the inspection meeting. Both quantitative and qualitative methods were used, including participant observation, structured interviews, generation of hypotheses from field notes, statistical tests of relationships, and interpretation of results with qualitative anecdotes. The study results show that past and present working relationships between inspection participants affect the amount of meeting time spent in different types of discussion, thus affecting the overall inspection meeting length. Reporting relationships and physical proximity also have an effect. The contribution of the study is a set of well-supported hypotheses for further investigation     

A validation of object-oriented design metrics as qualityindicators

This paper presents the results of a study in which we empirically investigated the suite of object-oriented (OO) design metrics introduced in (Chidamber and Kemerer, 1994). More specifically, our goal is to assess these metrics as predictors of fault-prone classes and, therefore, determine whether they can be used as early quality indicators. This study is complementary to the work described in (Li and Henry, 1993) where the same suite of metrics had been used to assess frequencies of maintenance changes to classes. To perform our validation accurately, we collected data on the development of eight medium-sized information management systems based on identical requirements. All eight projects were developed using a sequential life cycle model, a well-known OO analysis/design method and the C++ programming language. Based on empirical and quantitative analysis, the advantages and drawbacks of these OO metrics are discussed. Several of Chidamber and Kemerer's OO metrics appear to be useful to predict class fault-proneness during the early phases of the life-cycle. Also, on our data set, they are better predictors than “traditional” code metrics, which can only be collected at a later phase of the software development processes     

The ASC-Alliance Projects: A Case Study of Large-Scale Parallel Scientific Code Development

Computational scientists face many challenges when developing software that runs on large-scale parallel machines. However, software-engineering researchers haven't studied their software development processes in much detail. To better understand the nature of software development in this context, the authors examined five large-scale computational science software projects operated at the five ASC-Alliance centers.     

Structure-activity relationship study of 16 a-thiocamptothecins: an integrated in vitro and in silico approach

The instability of the hydroxylactone E ring represents a critical drawback of camptothecins, because the lactone ring is recognized to be essential for stabilization of topoisomerase I‐mediated DNA cleavage. In an attempt to investigate the effect of the thiopyridone pharmacophofore on the molecular and pharmacological features of the drug, we prepared a series of novel 16 a‐thiocamptothecin analogues. Due to the sulfur atom, a destabilization of the hydrogen bond between the hydroxy group in position 17 of the opened E ring and the carbonyl of the pyridone moiety is predicted, thus shifting the equilibrium toward the closed lactone form and increasing the lipophilic properties of the compounds. This feature was associated with superior antiproliferative potency, with reduced interaction with the human serum albumin and with substantial increase of the persistence of the topoisomerase I–DNA cleavable complex. These effects were prominent for thio‐SN38, the most active compound of the series. The favorable interactions at the molecular and cellular level of the reported thiocamptothecins confer promising features, and these compounds warrant preclinical development.     

An assessment of systems and software engineering scholars and institutions (2002-2006)

This paper summarizes a survey of publications in the field of systems and software engineering from 2002 to 2006. The survey is an ongoing, annual event that identifies the top 15 scholars and institutions over a 5-year period. The rankings are calculated based on the number of papers published in TSE, TOSEM, JSS, SPE, EMSE, IST, and Software. The top-ranked institution is Korea Advanced Institute of Science and Technology, Korea, and the top-ranked scholar is Magne Jørgensen of Simula Research Laboratory, Norway.     

Top 10 list [software development]

Software's complexity and accelerated development schedules make avoiding defects difficult. We have found, however, that researchers have established objective and quantitative data, relationships, and predictive models that help software developers avoid predictable pitfalls and improve their ability to predict and control efficient software projects. The article presents 10 techniques that can help reduce the flaws in your code