Equilibrium bulk polymerization of 1,3-dioxolan

Cationic bulk polymerization of 1,3-dioxolan has been carried out in sealed ampoules using a high vacuum technique. The polymerization is initiated with triethyl oxonium hexafluorophosphate and the equilibrium between monomer and active polymer is attained within a few hours. Specific volumes of pure monomer and polymer in solution of its own monomer have been measured. Equilibrium measurements have been performed in the 40° to 141·4°C temperature range and the ceiling temperature is estimated to be 144° ± 2°C. The effect of short polymer chains on the equilibrium is discussed briefly. Values of ΔG_lc, the free energy of polymerization of one mole of pure liquid monomer to one base-mole of amorphous polymer, are computed making allowance for the non-ideal mixing. Respective values of ?17.5 ± 0.8 kJ/mol and ?47.9 ± 2.2JK^?1mol^?1 are deduced for the corresponding ΔH_lc and ΔS_lc. ΔG_lc is also computed from published data on equilibrium polymerization of 1,3-dioxolan in various solvents and the combined results for both types of polymerization yield ΔH_lc = ?16.7 ± 0.5kJ/mol and ΔS_lc = ?45.8 ± 1.5JK^?1mol^?1 for the 20° to 140°C range.     

Bitumen fumes: review of work on the potential risk to workers and the present knowledge on its origin

Bitumens fumes contain polycyclic aromatic compounds (PAC). There is a possibility of long-term health effects following chronic exposure by inhalation or skin contamination in asphalt road pavers and highway maintenance workers. Epidemiological and experimental studies on this topic are reviewed and the possible causes of cancer discussed with a primary focus on heterocyclic polyaromatic compounds. In 2001, the results of the IARC epidemiological study confirmed an excess of lung cancer despite a lower cancer mortality. In vitro genotoxicity and mechanistic studies demonstrated a mutagenic effect of bitumen fume condensates (BFC) and some data suggested that the polycyclic aromatic hydrocarbons (PAH) analysed were not the major genotoxic compounds in bitumen fume condensates. Other compounds such as nitrogen-, sulfur- and/or oxygen-containing PAH or their alkyl substituted analogues, mutagenic in the Ames mutation assay, may be involved in the genotoxic effect of BFC. After skin painting with BFC, DNA adducts were found in skin, lung and lymphocytes of all the treated animals. Differences in the adduct patterns were also observed, but a more polar adduct was common to the three tissues and not observed in those from rats treated with coal-tar fume condensates (CTFC). Rat inhalation experiments with bitumen fumes confirmed the presence of a DNA-adduct in the lungs with the same Rf as the previous polar adduct. This adduct therefore merits further investigation as a potential biomarker in lymphocyte DNA to follow exposed workers. All the analytical data and the mechanistic data are complementary and suggest the potential role of thiophenes in the genotoxicity of bitumen fumes. Some thiophenes have lower mutagenic activity than their isosteric PAH, whereas others are very potent carcinogens. Generally, the sulfur analogues of PAH (SPAH) in bitumen fumes have a higher concentration than the PAH of similar molecular weight, whereas the SPAH in coal-tar fumes have a much lower concentration than the corresponding PAH. This may explain why the more polar adducts have been detected only in animals exposed to bitumen fume. In a skin carcinogenicity study of condensed asphalt roofing fumes, it has been demonstrated that the most active fractions were those containing a variety of aromatic SPAH. In conclusion to this review, there is an interest in determining the chemical identity of the major DNA adducts induced by BFC. This would allow experimental studies on the carcinogenic potency of these compounds and their validation as potential biomarkers. These compounds could thus merit further analytical investigation in preference to the PAH included in the list of the US Environmental Protection Agency that are currently being analysed by the industry in field studies.     

Short-range synthetic aperture imaging at 633 nm by digital holography

We present an active optical synthetic aperture-imaging system. A phase-step digital holographic setup is used as a wavefront sensor in the far field. The overlap of the holograms enables the estimation and compensation of their relative positions and phase with a speckle cross-correlation algorithm. Experimental results on a short-range synthetic aperture setup at 633 nm are presented that are based on 128 x 128 holograms. The synthesis is executed in one direction by means of rotation of the object. Test images show a significant gain of resolution in the synthesis direction. Processing errors are estimated through experiment. Random processing errors of a synthetic pupil composed of 33 merged holograms are negligible, but biases induced by unknown optical aberrations ofthe reference wave induce defocusing and astigmatism.     

The mechanisms involved in the impairment of hematopoiesis after autologous bone marrow transplantation

Hematopoiesis after autologous bone marrow transplantation (BMT) is characterized by a prolonged and severe deficiency of marrow progenitors for several years, especially of erythroid and megakaryocyte progenitors, while the peripheral blood cells and marrow cellularity have reached relatively normal values within a few weeks. These anomalies are comparable to those reported for allogeneic BMT, despite the absence of any allo-immune reaction or post-graft immunosuppressive therapy. Post-graft hematopoietic impairment is the consequence of quantitative and qualitative changes involving both stem cell and stromal compartments which are expressed by an impaired capacity of stem cell self-renewal and commitment towards erythroid and megakaryocytic lineages. Besides the toxicity of conditioning regimens, hematopoietic reconstitution using autologous grafts is particularly dependent on a combination of factors related to the patient, such as underlying disease and pre-graft chemotherapy regimens, and to the graft processing itself, such as in vitro purging with chemotherapeutic agents.     

Surface oxidation of silicon carbide: quantitative measurement and Rh effect

The oxidation degree of a commercial silicon carbide (SiC) powder was studied by means of Fourier transform infrared spectroscopy, using the intensity of the δ (SiO₂) band at 450 cm⁻¹ for measurements. Results are related to data obtained by LECO and gravimetric measurements. The influence of water in oxygen on the rate of the oxidation process was particularly examined. It was found that water alone had an oxidizing efficiency and that its mixture with oxygen increased the effect of the latter. The presence of Rh particles on SiC promoted the formation of SiO₂. However, as shown by the IR study of CO adsorption, this formation embedded the metal particles. This effect can be avoided by loading Rh on a precalcined SiC sample.     

Exclusive approach through the pulmonary artery or r. atrium in the surgical treatment of stenoses of the r. ventricle ejection channel (author's transl)

In the light of their experience of surgical treatment of right ventricle muscular stenoses, the authors have gradually abandoned the classical approach (ventriculotomy) and now exclusively use a new one through the tricuspid and pulmonary rings. The new approach considerably reduces the number and extent of enlargement patches in the infundibulum and should result in better preservation of the right ventricular function.     

Fast and nondestructive method of C(V) profiling of thin semiconductor layers on an insulating substrate

A method of C(V) profiling using only two mercury Schottky diodes is described. It allows fast profiles of doping level and conductivity of thin semiconductor layers on insulating substrates to be made, without any damage on the surface. This makes the method useful for wafer mapping in concentration, thickness and conductivity.     

Capacitors made by anodisation of aluminium for wideband GaAs ICs

The letter explains first how a capacitor made with anodic oxidations of aluminium can improve the bandwidth of GaAs integrated circuits. The technology of this capacitor is described with emphasis on the crossing of the edge of the capacitor by the upper metallisation. Capacitances of about 1500 pF/mm2 have been obtained with a breakdown voltage in the 5?10 V region.