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排序方式: 共有556条查询结果,搜索用时 15 毫秒
1.
E Spranzi JY Djeu SL Hoffman PK Epling-Burnette DK Blanchard 《Canadian Metallurgical Quarterly》1993,82(5):1578-1585
The present study shows that extracellular adenosine triphosphate (ATP) has the capacity to mediate dose-dependent lysis of the monocytic leukemia cell line THP-1. The lysis, assessed by 51Cr release, was found to be selective for ATP, because adenosine diphosphate (ADP) or other nucleotides were less effective in their ability to lyse the cells. The amount of 51Cr released was particularly enhanced by the stimulation of the cells with 1,000 U/mL of interferon gamma (IFN-gamma) for 3 days, and the sensitivity was time and dose dependent. Analysis of the mechanism of lysis indicated that the fully ionized form, ATP4-, mediated the lysis, because the addition of cation chelators or the absence of the divalent cations, Ca2+ and Mg2+, in the culture medium of a 6-hour 51Cr release assay increased the percent specific lysis. Therefore, the ATP receptors on THP-1 cells were classified as P2Z purinoceptors. Moreover, it is shown here that the Ca2+/calmodulin complex plays a role in the regulation of the lysis by extracellular ATP of THP-1 cells, because antagonists of this complex, such as trifluoperazine or KN-62, were found to inhibit the ATP-mediated cell lysis. 相似文献
2.
The majority of Ss included in studies of psychopathology are typically receiving psychoactive medication. In view of concerns regarding the confounding effects of psychoactive medication, it appears that researchers should provide information regarding at least the drug status of the Ss studied. A review of the articles on adult psychopathology that appeared in the Journal of Abnormal Psychology during a 5-yr period, however, revealed that nearly 50% of reports on Ss presumably receiving psychoactive medications failed to specify the medication status of those Ss. Few studies (15%) provided adequate information regarding the types and dosages of psychoactive drugs received by the Ss. It is argued that researchers should provide a full report of the psychoactive drugs received by research participants and, when participants are unmedicated, to indicate the reasons for drug-free status. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
Blanchard Edward B.; Appelbaum Kenneth A.; Guarnieri Patricia; Neff Debra F.; Andrasik Frank; Jaccard James; Barron Kevin D. 《Canadian Metallurgical Quarterly》1988,56(3):427
Tension and vascular headache patients, initially treated with biofeedback and/or relaxation training in either a minimal therapist contact protocol (3 visits) or an intensive individual protocol (10 or 16 visits) were followed-up prospectively for 2 years. In the first study, for the first 6 months of follow-up, half of all patients continued to keep headache diaries and were seen monthly and the other half had only minimal contact. The results at 1-year follow-up, based on 4 weeks of daily headache diaries, revealed equally good maintenance from both treatment protocols and from both follow-up conditions. In Study 2, we found that patients remained improved over pretreatment baseline levels at the 2-year follow-up regardless of initial treatment intensity. Approximately three quarters of vascular patients who were initially improved at posttreatment remained improved at 2 years. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Bourque Paul; Blanchard Louis; Saulnier Jo?l; Vézina Jean 《Canadian Metallurgical Quarterly》1992,24(1):118
Studied the relationship among age, physical health status, and psychic and somatic symptoms of depression among elderly adults. Human Ss: 318 male and female Canadian older adults (aged 65–102 yrs). Information on sociodemographic factors and health status was obtained using the Older American Research Scale, French version, by R. Lefran?ois et al (1988). A French version by P. Bourque and D. Beaudette (1982) of the Beck Depression Inventory was also used. The results were evaluated according to each S's sex, age, institutionalized residence status, and health status. Statistical tests were used. (English abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
Blanchard Kimberly A.; Morgenstern Jon; Morgan Thomas J.; Lobouvie Erich W.; Bux Donald A. 《Canadian Metallurgical Quarterly》2003,17(4):328
Negative consequences are an important component of the substance use change process, yet no standardized measure exists to assess consequences of use. This study evaluated the psychometric properties of the Inventory of Drug Use Consequences, a self-report measure assessing drinking and drug use consequences. Participants (N=252) were assessed at entry into outpatient substance abuse treatment. Items loaded strongly on 1 factor, and internal consistency of the total scale was high. Fifteen items with the highest correlations with the total scale were chosen to represent the construct. The shortened measure exhibited good internal consistency, convergent and discriminant validity, and detected change over time and may be the measure of substance use consequences that is lacking in the field. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
7.
F Davodeau MA Peyrat A Necker R Dominici F Blanchard C Leget J Gaschet P Costa Y Jacques A Godard H Vie A Poggi F Romagné M Bonneville 《Canadian Metallurgical Quarterly》1997,158(12):5603-5611
Several studies have demonstrated the existence of a murine NK1.1+ alphabeta T cell subset expressing V alpha14+ TCR alpha-chains with highly conserved invariant junctional sequences and able to secrete Th2 cytokines when exposed to CD1+ stimulator cells. In humans, alphabeta T cells carrying invariant V alpha24+ TCR alpha-chains highly homologous to those expressed by murine NK1.1 cells have been recently described. Here we show that these cells (referred to as V alpha24inv T cells) and murine NK1.1+ alphabeta T cells resemble each other in several ways. First, like their murine counterparts, T cells expressing high levels of V alpha24inv TCRs can be either CD4- CD8- double negative (DN) or CD4+, but they never express heterodimeric CD8 molecules. Second, most V alpha24inv T cells are brightly stained by NKRP1-specific mAb but not by mAb directed against other type II transmembrane proteins of the NK complex. Third, DN and particularly CD4+ V alpha24inv T cells are greatly enriched for IL-4 producers. The concomitant expression of highly conserved TCRs of a particular set of NK markers and of Th2 cytokines in human and murine alphabeta T cells suggests a coordinate acquisition of these phenotypic and functional properties. Furthermore, the relatively high frequency of human V alpha24inv T cells, which are presently shown to represent on average 1/500 PBL, and the high interindividual variations of the size of this cell subset under physiologic conditions go for a major role played by alphabeta T cells carrying invariant TCR in a large array of immune responses. 相似文献
8.
Edwin Ramaroson Gilbert Blanchard Michel Che Jean-Michel Tatibouët 《Catalysis Letters》1992,15(4):393-400
The oxidative dimerisation of propene to 1,5-hexadiene has been investigated on Bi-Zn-O catalysts. The Bi48ZnO73 phase, observed in the catalysts calcined at 700 ° C is an active and selective catalyst for the formation of 1,5-hexadiene. The best catalytic performance (1,5-hexadiene selectivity 64%) has been obtained at 525 ° C, with a propene to oxygen ratio of 26, on a catalyst formed by Bi48ZnO73 with a small excess of ZnO. 相似文献
9.
The nucleation, growth and coalescence of grain-boundary cavities is the primary damage mechanism observed during creep of structural ceramics. Furthermore, grain-boundary sliding (GBS) has been identified as the driving force process. Although the creep characteristics of structural ceramics have been extensively studied, very little is known about the details of GBS during creep and how GBS relates to cavitation kinetics. This paper presents the results of a study using a machine vision system to measure Mode II GBS displacements in a Lucalox Al2O3. Specifically, sliding displacements as large as 0.4 m were measured. The measured displacements indicate that some grain boundaries experienced shear strains and strain rates of 4200% and 2.3×10–2 s–1, respectively. The techniques utilized for these measurements are described in detail, and data gathered during a 2 1/2 h compressive creep test under a stress of 138 MPa at 1600 °C are presented and discussed. 相似文献
10.
J. F. Barbot P. Girault C. Blanchard I. A. Hümmelgen 《Journal of Materials Science》1995,30(13):3471-3474
Deep level transient spectroscopy (DLTS) has been used to study the traps associated with dislocations in n-type Hg0.3Cd0.7Te. Dislocations have been generated by ion implantation at high fluence. Two of the broadened lines (E1=E
c–0.22eV and E1=E
c–0.34eV), we have observed, show a logarithmic dependence with the filling pulse. They are characteristic of point defect clouds surrounding or generated by the dislocations. An unusual broadened line (E2=E
c–0.27eV) has also been observed, its amplitude decreases for filling pulses longer than 50 s. This can be explained by a configuration change of the defect leading to the appearance of a new DLTS line. In addition, an electron trap (EP4=E
c–0.22eV), which seems to behave like an isolated point defect, has also been found. 相似文献