Formation of neutral molecules of potential stellar interest by neutralisation of negative ions in a mass spectrometer. The application of experiment and molecular modelling in concert

This paper is a modified version of a lecture which describes the synthesis, structure and reactivity of some neutral molecules of stellar significance. The neutrals are formed in the collision cell of a mass spectrometer following vertical Franck-Condon one electron oxidation of anions of known bond connectivity. Neutrals are characterised by conversion to positive ions and by extensive theoretical studies at the CCSD(T)/aug-cc-pVDZ//B3LYP/6-31G(d) level of theory. Four systems are considered in detail, viz (i) the formation of linear C(4) and its conversion to the rhombus C(4), (ii) linear C(5) and the atom scrambling of this system when energised, (iii) the stable cumulene oxide CCCCCO, and (iv) the elusive species O(2)C-CO. This paper is not intended to be a review of interstellar chemistry: examples are selected from our own work in this area.     

The acoustic attenuation and hydraulic roughness in a large section sewer pipe with periodical obstacles.

The acoustic attenuation, relative sound pressure levels and the equivalent Nikuradse wall roughness under variable flow conditions in a 600 mm concrete sewer pipe are experimentally investigated. The values of the acoustic attenuation are obtained in the case of airborne sound propagation in the dry pipe. A range of values of the equivalent wall roughness is artificially generated by deploying a periodical array of engineering bricks. A novel method of rapid evaluation of the acoustic attenuation is proposed. The method relies upon sound reflections from the adjacent manholes. The results demonstrate that the acoustic attenuation depends strongly on the value of the equivalent wall roughness. This work can pave the way to the efficient methodology for the in-situ, physical evaluation of the equivalent hydraulic roughness of new and existing sewer networks.     

How can and do Australian doctors promote physical activity?

We describe a modified technique for the salvage of a total knee arthroplasty after disruption of the extensor mechanism. Between January and December 1992, seven patients had reconstruction of the extensor mechanism with use of a medial or an extended medial gastrocnemius flap. Six of the seven patients were followed for a mean of thirty-three months (range, twenty-six to forty-one months) and were evaluated both preoperatively and postoperatively with regard to the knee and functional scores of The Knee Society as well as the range of motion, extensor lag, walking status, and patellar height. The seventh patient was lost to follow-up six months postoperatively and was excluded from the analysis of the results. Preoperatively, the knee and functional scores were 16 +/- 12.3 points and 12 +/- 12.1 points (mean and standard deviation), respectively; the mean range of motion was 70 +/- 44.0 degrees; and the mean extensor lag was 53 +/- 33.4 degrees. Postoperatively, the mean knee and functional scores improved to 82 +/- 12.4 points and 51 +/- 23.0 points, respectively; the mean range of motion improved to 100 +/- 21.8 degrees; and the mean extensor lag decreased to 24 +/- 18.8 degrees. After the procedure, all patients who previously had been dependent on a walker were able to walk about the community with or without a cane, and those who had been dependent on a wheelchair were able to walk with the assistance of a walker. Patellar height was measured according to the method of Insall and Salvati for the four patients who had a patella. Preoperatively, the patellar heights were grossly abnormal; postoperatively, they more closely approached accepted normal values for three of the four patients. Reconstruction of a complicated rupture of the extensor mechanism with use of a medial gastrocnemius transposition flap after total knee arthroplasty is a reliable option for treatment.     

Multiple Antenna Enhancements for a High Rate CDMA Packet Data System

A High Data Rate (HDR) system has been proposed for providing downlink wireless packet service by using a channel-aware scheduling algorithm to transmit to users in a time-division multiplexed manner. In this paper, we propose using multiple antennas at the transmitter and/or at the receiver to improve performance of an HDR system. We consider the design tradeoffs between scheduling and multi-antenna transmission/detection strategies and investigate the average Shannon capacity throughput as a function of the number of antennas assuming ideal channel estimates and rate feedback. The highest capacities are achieved using multiple antennas at both the transmitter and receiver. For such systems, the best performance is achieved using a multi-input multi-output capacity-achieving transmission scheme such as BLAST (Bell Labs Layered Space-Time) in which the transmitted signal is coded in space and time, and the receive antennas are used to resolve the spatial interference. In the second part of the paper, we discuss practical transmitter and receiver architectures using BLAST for approaching the theoretical gains promised by the capacity analysis. Because the terminal receivers will be portable devices with limited computational and battery power, we perform a computational complexity analysis of the receiver and make high-level assessments on its feasibility. We conclude that the overall computational requirements are within the reach of current hardware technology.     

The relationship of hypercapnic ventilatory responses to age, gender and athleticism

When a gas mixture containing carbon dioxide (CO2) is inhaled by an individual, alveolar ventilation is increased. This ventilatory response to CO2 highlights the relationship between the increase in exercise ventilation and the increase in alveolar CO2 pressure (paCO2). This response is mediated centrally by brainstem chemoreceptors in the medulla and, to a lesser extent, peripherally by the carotid and aortic bodies. However, the response of increased breathing to rising paCO2 varies markedly among individuals. The responses to CO2 rebreathing have been investigated by a variety of research groups for different reasons. The range of responses by children and adults including: gender differences; responses by athletes; the relationship between age and body size; and whether it is an acquired or inherited response have been studied. The following is a summary of these different aspects of CO2 rebreathing has been complied to assist researchers studying any single or multiple facets of the area.     

A 690-mW 1-Gb/s 1024-b, rate-1/2 low-density parity-check codedecoder

A 1024-b, rate-1/2, soft decision low-density parity-check (LDPC) code decoder has been implemented that matches the coding gain of equivalent turbo codes. The decoder features a parallel architecture that supports a maximum throughput of 1 Gb/s while performing 64 decoder iterations. The parallel architecture enables rapid convergence in the decoding algorithm to be translated into low decoder switching activity resulting in a power dissipation of only 690 mW from a 1.5-V supply     

Differentiation of complex lipid isomers by radical-directed dissociation mass spectrometry

Contemporary lipidomics protocols are dependent on conventional tandem mass spectrometry for lipid identification. This approach is extremely powerful for determining lipid class and identifying the number of carbons and the degree of unsaturation of any acyl-chain substituents. Such analyses are however, blind to isomeric variants arising from different carbon-carbon bonding motifs within these chains including double bond position, chain branching, and cyclic structures. This limitation arises from the fact that conventional, low energy collision-induced dissociation of even-electron lipid ions does not give rise to product ions from intrachain fragmentation of the fatty acyl moieties. To overcome this limitation, we have applied radical-directed dissociation (RDD) to the study of lipids for the first time. In this approach, bifunctional molecules that contain a photocaged radical initiator and a lipid-adducting group, such as 4-iodoaniline and 4-iodobenzoic acid, are used to form noncovalent complexes (i.e., adduct ions) with a lipid during electrospray ionization. Laser irradiation of these complexes at UV wavelengths (266 nm) cleaves the carbon-iodine bond to liberate a highly reactive phenyl radical. Subsequent activation of the nascent radical ions results in RDD with significant intrachain fragmentation of acyl moieties. This approach provides diagnostic fragments that are associated with the double bond position and the positions of chain-branching in glycerophospholipids, sphingomyelins and triacylglycerols and thus can be used to differentiate isomeric lipids differing only in such motifs. RDD is demonstrated for well-defined lipid standards and also reveals lipid structural diversity in olive oil and human very-low density lipoprotein.     

Sewer system design moving into the 21st century--a UK perspective.

Change in external factors, such as environmental legislation and climate change, will mean the future of sewerage systems is likely to be different from the past. Combined sewerage systems comprise the vast majority of existing sewers in countries such as the UK. A study funded by UK Water Industry Research Ltd has reviewed the current state of sewerage within the UK, the likely drivers for change and the consequent future impacts over a 75 year timescale. Potential responses to address the anticipated changes have also been considered. It is concluded that due to the wide extent and value of existing sewer systems, these will continue to be used for the foreseeable future. However, in order to meet the major challenges as a result of changing external factors, these need to be operated more effectively, new ideas need to be explored and moves to develop better and more integrated water management systems need to be started if sewer systems in the UK are to provide the anticipated required levels of service well into the 21st century.     

An insect vision-based motion detection chip

The architectural and circuit design aspects of a mixed analog/digital very large scale integration (VLSI) motion detection chip based on models of the insect visual system are described. The chip comprises two one-dimensional 64-cell arrays as well as front-end analog circuitry for early visual processing and digital control circuits. Each analog processing cell comprises a photodetector, circuits for spatial averaging and multiplicative noise cancellation, differentiation, and thresholding. The operation and configuration of the analog cells is controlled by digital circuits, thus implementing a reconfigurable architecture which facilitates the evaluation of several newly designed analog circuits. The chip has been designed and fabricated in a 1.2-μm CMOS process and occupies an area of 2×2 mm²     

Performance analysis of a color CMOS photogate image sensor

The performance of a color CMOS photogate image sensor is reported. It is shown that by using two levels of correlated-double sampling it is possible to effectively cancel all fixed-pattern noise due to read-out circuit mismatch. Instead the fixed-pattern noise performance of the sensor is limited by dark current nonuniformity at low signal levels, and conversion gain nonuniformity at high signal levels. It is further shown that the imaging performance of the sensor is comparable to low-end CCD sensors but inferior to that reported for high-end CCD sensors due to low quantum efficiency, high dark current, and pixel cross-talk. As such the performance of CMOS sensors is limited at the device level rather than at the architectural level. If the imaging performance issues can be addressed at the fabrication process level without increasing cost or degrading transistor performance, CMOS has the potential to seriously challenge CCD as the solid-state imaging technology of choice due to low power dissipation and compatibility with camera system integration