Optimality of the sequential probability ratio test fornonstationary observations

Bayesian analysis is used to show that Wald's sequential probability ratio test with varying thresholds is optimal for the nonstationary situation, where the observed samples are independent but not identically distributed. Some important properties useful for the design of the test thresholds are discussed. Wald's lower bound, generalized to the nonstationary situation, is also presented. The results have important applications in situations where the observed signal is time-varying. such as in radar signal processing, image processing, and spread spectrum communications     

Multiple antenna systems: their role and impact in future wireless access

Multiple antennas play an important role in improving radio communications. In view of this role, the area of multiple antenna communication systems is in the forefront of wireless research. This article reviews two key related aspects of multiple antenna communication systems: multiple access interference mitigation at the receiver via multi-user beamforming; and space-time modulation and coding for MIMO systems. It is shown that both multi-user and MIMO receivers share similar signal processing and complexity tradeoffs.. Following that, a general unified framework for assessing different types of space-time modulation for MIMO systems is introduced. These space-time modulation methods are then compared in terms of Shannon capacity over multipath channels. Key MIMO system performance and implementation issues are also highlighted.     

Total cross section of solid mesitylene, toluene and a mixture of them at thermal neutron energies

The total neutron cross sections of mesitylene, toluene and a solution 3:2 by volume of mesitylene and toluene were measured at the electron LINAC based pulsed neutron source of Centro Atómico Bariloche. Measurements were performed at 180 K, 120 K and 31.6 K for mesitylene and at 120 K and 31.6 K for toluene and a solution 3:2 by volume of mesitylene and toluene. The systems are potential moderator materials to be considered in the design of a cold neutron source due to their high resistance to radiation and the richness in low-energy excitations of their frequency spectra, that lead to produce an enhanced cold neutron flux.     

The performance of camera translation direction estimators fromoptical flow: analysis, comparison, and theoretical limits

A noniterative method using optical flow to recover the translation direction of a moving camera has been previously proposed by Heeger-Jepson (1992). In this paper we present a detailed explanation of the bias in this algorithm and compare methods for eliminating this bias, as well as presenting a comprehensive error analysis. This analysis includes a necessary modification to the Cramer-Rao lower bound (CRLB), We propose a simple iterative modification to the algorithm which produces unbiased translation direction estimates that approach the CRLB. Numerical results are used to compare the various techniques on synthetic and real image sequences     

X‐ray micrographic imaging system based on COTS CMOS sensors

This paper presents the use of commercial off the shelf CMOS image sensors for the acquisition of X‐ray images with high spatial resolution. The X‐ray images, with application in biology, electronic components inspection, and paleontology research, are obtained with 8‐keV photons from a Cu tube. The quantum efficiency of the detector is estimated using attenuation lengths of photons in the sensor and compared to traditional scintillator conversion layers. The spatial resolution observed with the sensor is limited by the charge redistribution produced after photon interaction with Si.     

Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase

The Na,K-ATPase comprises a catalytic alpha subunit and a glycosylated beta subunit. Another membrane polypeptide, gamma, first described by Forbush et al. (Forbush, B., III, Kaplan, J. H., and Hoffman, J. F. (1978) Biochemistry 17, 3667-3676) associates with alpha and beta in purified kidney enzyme preparations. In this study, we have used a polyclonal anti-gamma antiserum to define the tissue specificity and topology of gamma and to address the question of whether gamma has a functional role. The trypsin sensitivity of the amino terminus of the gamma subunit in intact right-side-out pig kidney microsomes has confirmed that it is a type I membrane protein with an extracellular amino terminus. Western blot analysis shows that gamma subunit protein is present only in membranes from kidney tubules (rat, dog, pig) and not those from axolemma, heart, red blood cells, kidney glomeruli, cultured glomerular cells, alpha1-transfected HeLa cells, all derived from the same (rat) species, nor from three cultured cell lines derived from tubules of the kidney, namely NRK-52E (rat), LLC-PK (pig), or MDCK (dog). To gain insight into gamma function, the effects of the anti-gamma serum on the kinetic behavior of rat kidney sodium pumps was examined. The following evidence suggests that gamma stabilizes E1 conformation(s) of the enzyme and that anti-gamma counteracts this effect: (i) anti-gamma inhibits Na,K-ATPase, and the inhibition increases at acidic pH under which condition the E2(K) --> E1 phase of the reaction sequence becomes more rate-limiting, (ii) the oligomycin-stimulated increase in the level of phosphoenzyme was greater in the presence of anti-gamma indicating that the antibody shifts the E1 left and right arrow left and right arrow E2P equilibria toward E2P, and (iii) when the Na+-ATPase reaction is assayed with the Na+ concentration reduced to levels ( --> E2P transition, anti-gamma is stimulatory. These observations taken together with evidence that the pig gamma subunit, which migrates as a doublet on polyacrylamide gels, is sensitive to digestion by trypsin, and that Rb+ ions partially protect it against this effect, indicate that the gamma subunit is a tissue-specific regulator which shifts the steady-state equilibria toward E1. Accordingly, binding of anti-gamma disrupts alphabeta-gamma interactions and counteracts these modulatory effects of the gamma subunit.     

Tandem-free VoIP conferencing: a bridge to next-generation networks

This article surveys approaches to teleconferencing in voice over IP networks. The considerations for conferencing include perceived quality, scalability, control, and compatibility. Architectures used for conferencing range from centralized bridges to full mesh. Centralized conference bridges used with compressed speech degrade speech quality when multiple talkers are mixed and subjected to tandem coding operations. Full mesh and multicast solutions (mixing at the end-points) are inappropriate when the number of conferees is large. This article discusses a hybrid solution that incorporates tandem-free bridging (the bridge selects and forwards packets) and endpoint mixing.     

Evidence that Ser775 in the alpha subunit of the Na,K-ATPase is a residue in the cation binding pocket

Substitution of alanine for Ser775 in a ouabain-resistant alpha1 sheep isoform causes a 30-fold decrease in apparent affinity for K+ as an activator of the Na,K-ATPase, as well as an increase in apparent affinity for ATP (Arguello, J. M., and Lingrel, J. B (1995) J. Biol. Chem. 270, 22764-22771). This study was carried out to determine whether Ser775 is a direct cation-ligating residue or whether the change in apparent affinity for K+ is secondary to a conformational alteration as evidenced in the change in ATP affinity, with the following results. Kinetics of K+(Rb+) influx into intact cells show that the change is due to a change in K+ interaction at the extracellular surface. The K+ dependence of formation of K+-occluded enzyme (E2(K)) and of the rate of formation of deoccluded enzyme from E2(K) indicate that the Ser775 --> Ala mutation results in a marked increase (>/=30-fold) in rate of release of K+ from E2(K). The high affinity Na+-like competitive antagonist 1,3-dibromo2,4,6-tris-(methylisothiouronium)benzene (Br2TITU), which interacts with the E1 conformation and blocks cytoplasmic cation binding (Hoving, S., Bar-Shimon, M., Tijmes, J. J. , Tal, D. M., and Karlish, S. J. D. (1995) J. Biol. Chem. 270, 29788-29793), inhibits Na+-ATPase of the mutant less than the control enzyme. With intact cells, Br2TITU acts as a competitive inhibitor of extracellular K+ activation of both the mutant and control enzymes. In this case, the mutant was more sensitive to inhibition. With vanadate as a probe of conformation, a difference in conformational equilibrium between the mutant and control enzymes could not be detected under turnover conditions (Na+- ATPase) in the absence of K+. These results indicate that the increase in apparent affinity for ATP effected by the Ser775 --> Ala mutation is secondary to a change in intrinsic cation affinity/selectivity. The large change in affinity for extracellular K+ compared with cytoplasmic Na+ and to Br2TITU binding supports the conclusion that the serine hydroxyl is either part of the K+-gate structure or a direct cation-ligating residue that is shared by at least one Na+ ion, albeit with less consequence on rate constants for Na+ binding or release compared with K+.     

Static test case prioritization using topic models

Software development teams use test suites to test changes to their source code. In many situations, the test suites are so large that executing every test for every source code change is infeasible, due to time and resource constraints. Development teams need to prioritize their test suite so that as many distinct faults as possible are detected early in the execution of the test suite. We consider the problem of static black-box test case prioritization (TCP), where test suites are prioritized without the availability of the source code of the system under test (SUT). We propose a new static black-box TCP technique that represents test cases using a previously unused data source in the test suite: the linguistic data of the test cases, i.e., their identifier names, comments, and string literals. Our technique applies a text analysis algorithm called topic modeling to the linguistic data to approximate the functionality of each test case, allowing our technique to give high priority to test cases that test different functionalities of the SUT. We compare our proposed technique with existing static black-box TCP techniques in a case study of multiple real-world open source systems: several versions of Apache Ant and Apache Derby. We find that our static black-box TCP technique outperforms existing static black-box TCP techniques, and has comparable or better performance than two existing execution-based TCP techniques. Static black-box TCP methods are widely applicable because the only input they require is the source code of the test cases themselves. This contrasts with other TCP techniques which require access to the SUT runtime behavior, to the SUT specification models, or to the SUT source code.