A numerical absorbing boundary condition for finite difference andfinite element analysis of open periodic structures

In this paper we present a novel approach to deriving local boundary conditions, that can be employed in conjunction with the Finite Difference/Finite Element Methods (FD/FEM) to solve electromagnetic scattering and radiation problems involving periodic structures. The key step in this approach is to derive linear relationships that link the value of the field at a boundary grid point to those at the neighboring points. These linear relationships are identically satisfied not only by all of the propagating Floquet modes but by a few of the leading evanescent ones as well. They can thus be used in lieu of absorbing boundary conditions (ABCs) in place of the usual FD/FEM equations for the boundary points. Guidelines for selecting the orders of the evanescent Floquet modes to be absorbed are given in the paper. The present approach not only provides a simple way to derive an accurate boundary condition for mesh truncation, but also preserves the banded structure of the FD/FEM matrices. The accuracy of the proposed method is verified by using an internal check and by comparing the numerical results with the analytic solution for perfectly conducting strip gratings     

Analysis and optimization of waveguide multiapplicator hyperthermiasystems

A method is proposed for determining the excitation coefficients of an antenna array operating in a large rectangular waveguide and used as a hyperthermia system. The excitation coefficients of the array elements are optimized for attaining an improved specific absorption rate (SAR) distribution around a deep-seated tumor. The method is applied to a two-dimensional problem of a piecewise homogeneous post in a waveguide representing a section of the human torso. The array is operating below the cutoff frequency of the dominant mode of the waveguide. Numerical simulations have been performed to check the effectiveness of this approach. The results show that by using the proposed optimization method, SAR distributions can be improved     

Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease

A major hallmark of Parkinson’s disease (PD) is the fatal destruction of dopaminergic neurons within the substantia nigra pars compacta. This event is preceded by the formation of Lewy bodies, which are cytoplasmic inclusions composed of α-synuclein protein aggregates. A triad contribution of α-synuclein aggregation, iron accumulation, and mitochondrial dysfunction plague nigral neurons, yet the events underlying iron accumulation are poorly understood. Elevated intracellular iron concentrations up-regulate ferritin expression, an iron storage protein that provides cytoprotection against redox stress. The lysosomal degradation pathway, autophagy, can release iron from ferritin stores to facilitate its trafficking in a process termed ferritinophagy. Aggregated α-synuclein inhibits SNARE protein complexes and destabilizes microtubules to halt vesicular trafficking systems, including that of autophagy effectively. The scope of this review is to describe the physiological and pathological relationship between iron regulation and α-synuclein, providing a detailed understanding of iron metabolism within nigral neurons. The underlying mechanisms of autophagy and ferritinophagy are explored in the context of PD, identifying potential therapeutic targets for future investigation.     

Sensitivity analysis of narrowband photonic crystal filters and waveguides to structure variations and inaccuracy

Photonic crystal microcavities, formed by local defects within an otherwise perfectly periodic structure, can be used as narrowband optical resonators and filters. The coupled-cavity waveguide (CCW) is a linear array of equally spaced identical microcavities. Tunneling of light between microcavities forms a guiding effect, with a central frequency and bandwidth controlled by the local defects' parameters and spacing, respectively. We employ cavity perturbation theory to investigate the sensitivity of microcavities and CCWs to random structure inaccuracies. For the microcavity, we predict a frequency shift that is due to random changes in the lattice structure and show an approximate linear dependence between the standard deviation of the structure inaccuracy and that of the resonant frequency. The effect of structural inaccuracy on the CCW devices, however, is different; it has practically no effect on the CCW performance if it is below a certain threshold but may destroy the CCW if this threshold is exceeded.     

Variation in host susceptibility and infectiousness generated by co-infection: the myxoma-Trichostrongylus retortaeformis case in wild rabbits.

One of the conditions that can affect host susceptibility and parasite transmission is the occurrence of concomitant infections. Parasites interact directly or indirectly within an individual host and often these interactions are modulated by the host immune response. We used a free-living rabbit population co-infected with the nematode Trichostrongylus retortaeformis, which appears to stimulate an acquired immune response, and the immunosuppressive poxvirus myxoma. Modelling was used to examine how myxoma infection alters the immune-mediated establishment and death/expulsion of T. retortaeformis, and consequently affects parasite intensity and duration of the infection. Simulations were based on the general TH1-TH2 immunological paradigm that proposes the polarization of the host immune response towards one of the two subsets of T helper cells. Our findings suggest that myxoma infections contribute to alter host susceptibility to the nematode, as co-infected rabbits showed higher worm intensity compared with virus negative hosts. Results also suggest that myxoma disrupts the ability of the host to clear T. retortaeformis as worm intensities were consistently high and remained high in old rabbits. However, the co-infection model has to include some immune-mediated nematode regulation to be consistent with field data, indicating that the TH1-TH2 dichotomy is not complete. We conclude that seasonal myxoma outbreaks enhance host susceptibility to the nematode and generate highly infected hosts that remain infectious for a longer time. Finally, the virus-nematode co-infection increases heterogeneities among individuals and potentially has a large effect on parasite transmission.     

Optimal excitation of multiapplicator systems for deep regionalhyperthermia

A method is proposed for determining the excitation amplitudes and phases of the elements of electromagnetic multiapplicator systems for optimizing the specific absorption rate (SAR) distribution around a deep-seated tumor. In this method, the ratio of the power dissipated in the tumor to a weighted summation of the powers supplied to the surrounding regions is optimized. The optimization procedure is combined with a recently proposed effective technique for analysis of various electromagnetic scattering and interaction problems. The general principle is applied to a two-dimensional problem of a piecewise homogeneous cylinder heated by an array of electric current filaments placed outside the cylinder. Numerical simulations are performed to check the effectiveness of the approach. The results demonstrate that using this optimization method, improved SAR distributions can be achieved. The extension to three-dimensional configurations is discussed.     

Analysis of electromagnetic scattering from dielectric cylinders using a multifilament current model

A moment solution is presented for the problem of transverse magnetic (TM) scattering from homogeneous dielectric cylinders. The moment solution uses fictitious filamentary currents to simulate both the field scattered by the cylinder and the field inside the cylinder and in turn point-matches the continuity conditions for the tangential components of the electric and magnetic fields across the cylinder surface. The procedure is simple to execute and is general in that cylinders of arbitrary shape and complex permittivity can be handled effectively. Metallic cylinders are treated as reduced cases of the general procedure. Results are given and compared with available analytic solutions, which demonstrate the very good performance of the procedure.     

New designs of ultra wide-band communication antennas using agenetic algorithm

The paper investigates new designs of loaded wire antennas with broad-band characteristics. A two-step design procedure is proposed for the design. First, different unloaded antennas configurations are examined with a view to identifying candidates that exhibit the lowest voltage standing wave ratio (VSWR) and highest gain characteristics. Multi-armed antennas with straight wire segments that branch off symmetrically from a central stem are found to be excellent potential candidates. Next, the antenna with the best performance is loaded with resonant tank circuits and a matching network is designed. The loads can enhance the antenna characteristics to yield high gain and low VSWR by modifying the current distribution and can force it to radiate nearer to the horizon in the elevation plane with an almost omnidirectional pattern in the azimuth plane. An efficient optimization procedure based on the genetic algorithm is employed to simultaneously determine the load components, their locations, and the parameters of the matching network. Several examples of four- and eight-arm antennas with bandwidth of 7.5:1 and 15:1 illustrate the effectiveness of the design procedure     

A fast physical optics (FPO) algorithm for high frequency scattering

A novel algorithm referred as the fast physical optics (FPO) for computing the back-scattered field over a range of aspect angles and frequencies is presented. The computation is performed in the framework of the conventional physical optics approximation appropriate for the high frequency scattering regime. The proposed algorithm is, also, directly applicable to fixed angle bistatic configurations and a variety of single scattering formulations. The method comprises two steps. First, a decomposition of the scatterer into subdomains and computation of the pertinent scattering characteristics of each subdomain. Second, interpolation, phase-correction and aggregation of the scattering patterns of the subdomains into the final pattern of the whole body. A multilevel algorithm is formulated via a recursive application of the domain decomposition and aggregation steps. The computational structure of the multilevel algorithm resembles that of the FFT. The proposed method is especially suited for generation of synthetic data for radar imaging simulation.     

Liposomal daunorubicin in advanced Kaposi's sarcoma: a phase II study

We report a non-randomized Phase II clinical trial to assess the efficacy and safety of liposomal daunorubicin (DaunoXome) in the treatment of AIDS related Kaposi's sarcoma. Eleven homosexual men with advanced Kaposi's sarcoma were entered in the trial. Changes in size, colour and associated oedema of selected 'target' lesions were measured. Clinical, biochemical and haematological toxicities were assessed. Ten subjects were evaluated. A partial response was achieved in four, of whom two subsequently relapsed. Stabilization of Kaposi's sarcoma occurred in the remaining six, maintained until the end of the trial period in four. The drug was generally well tolerated, with few mild symptoms of toxicity. The main problem encountered was haematological toxicity, with three subjects experiencing severe neutropenia (neutrophil count < 0.5 x 10(9)/l). There was no evidence of cardiotoxicity. In this small patient sample, liposomal daunorubicin was an effective and well tolerated agent in the treatment of Kaposi's sarcoma.