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排序方式: 共有527条查询结果,搜索用时 11 毫秒
1.
Sarah Gilgunn Keefe Murphy Henning Stckmann Paul J. Conroy T. Brendan Murphy R. William Watson Richard J. OKennedy Pauline M. Rudd Radka Saldova 《International journal of molecular sciences》2020,21(23)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies. 相似文献
2.
This article is the second of two papers that review the field of spatially sensitive social scientific research into the links between social status and transport disadvantage. The first paper undertook a comprehensive review of the social scientific and transport planning literature to mark the level of development in the field and identify conceptual and methodological issues and constraints in this field of inquiry. The present article supports the advancement of socially and geographically sensitive transport research by opportunities for the development of more sophisticated spatial analytical methodologies. The approach we present is able to account for factors not previously addressed in either social or transport planning research, in particular the temporal dimensions of transport service accessibility. The article articulates the methodology through an empirical case study of socio-spatial transport disadvantage within the Gold Coast City. The article demonstrates that there are important theoretical and practical lessons to be gained for researchers and policy makers in addressing the social dimensions of transport and infrastructure provision. Further, the article argues that an attentiveness to new ways of combining and representing social and transport data-sets can promote policy relevant empirical social inquiry. The article also contributes in a productive way to the empirical knowledge of Australia's sixth-largest metropolitan area, which is often overlooked by urban scholars. 相似文献
3.
Bradley Brendan P.; Gossop Michael; Brewin Chris R.; Phillips Grania; Green Lynette 《Canadian Metallurgical Quarterly》1992,60(3):470
Investigated whether attributions of opiate addicts would predict both their ability to abstain from future use and their reactions to abstinence violations. Measures of generalized beliefs about responsibility for positive and negative outcomes and specific attributions about relapse episodes were elicited from 80 addicts at the time of admission for inpatient detoxification and treatment. Addicts who at admission attributed to themselves greater responsibility for negative outcomes and who attributed relapse episodes to more personally controllable factors were subsequently (at 6-mo follow-up) more likely either to be completely abstinent or to contain the effects of temporary lapses into opiate use. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
Brendan S. Gillon 《Journal of Logic, Language and Information》2014,23(3):275-285
In this paper, I address the problem wherein the same English word permits one of its complement positions to be satisfied by phrases of different categories. A well-known example of such an English word is the copula to be, whose complements include adjective phrases, noun phrases, prepositional phrases and adverbial phrases. I provide a way to treat such words, in particular verbs, as single lexical items through a conservative extension of the usual treatment of word classification as a pair comprising a part of speech category and a complement list. I then show how a further conservative extension of complement lists permits a satisfactory formalization of doubly complemented English verbs which are synonymous under a permutation of their complements. These verbs include, but are not limited to, so-called double object constructions. 相似文献
5.
6.
In this paper, we introduce new methods for finding functions that lower bound the value function of a stochastic control problem, using an iterated form of the Bellman inequality. Our method is based on solving linear or semidefinite programs, and produces both a bound on the optimal objective, as well as a suboptimal policy that appears to works very well. These results extend and improve bounds obtained in a previous paper using a single Bellman inequality condition. We describe the methods in a general setting and show how they can be applied in specific cases including the finite state case, constrained linear quadratic control, switched affine control, and multi‐period portfolio investment. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
7.
Brendan C. Ebner Mark Lintermans Mark Dunford 《Lakes & Reservoirs: Research and Management》2011,16(1):23-33
Home‐range estimates are an important input to species recovery plans. Our aim was to estimate the home‐range size of the endangered Macquarie Perch in the lower Cotter River catchment, Australia. In total, fourteen home‐range estimates were calculated from intensive radio‐tracking of adult individuals over a minimum of five diel periods in either autumn (n = 5) or spring (n = 9). Home‐range (95% Kernel) and core area (50% Kernel) were calculated by Kernel estimation and corrected for overlap with land. Seasonal estimates of home‐range and core area were not asymptotic in relation to cumulative number of radio‐fixes in four of fourteen cases. The mean within‐season home‐range of adult Macquarie perch was 5.5 ha ranging from 0.2 to 18.4 ha, based on 10 cumulative estimates that were asymptotic in relation to radio‐tracking effort. All five individuals radio‐tracked in autumn occupied a single core area, whereas in spring, six individuals occupied a single core area and three individuals each occupied three core areas. Despite individuals moving on a scale almost comparable to Cotter Reservoir (48.5 ha), only a single radio‐tagged individual was found to leave the reservoir and enter the river. Regional fisheries managers are generally aware of the requirement for Macquarie perch to access flowing water for spawning in south‐eastern Australia; however, in the Cotter River catchment, the protection of habitat for this species within Cotter Reservoir is also paramount. Our study highlights the importance of reservoirs for conserving a threatened aquatic species. 相似文献
8.
Brendan Davis 《Journal of Electronic Testing》1994,5(2-3):157-169
A long and deep recession, coupled with continuous competitive pressure to reduce costs, is forcing many companies to review their test strategies. Testing costs have become a more significant proportion of the overall manufacturing cost even though manufacturing yields have increased dramatically over the past ten or twelve years. This causes attention to be focused on testing costs as a key source of cost reduction. The increased use of DFT and the integration of design and test are very positive moves towards controlling testing costs but other methods employed can often backfire. The increased use of low priced testers is one such method. The pressure to reduce costs, higher process yields and exhortations that testing adds no value can lead the test engineering manager to take the cheap route. In reality this can often turn out to be an expensive decision. The only way to avoid expensive mistakes is to perform an economic analysis of the alternative courses of action. In most cases this is done, but not always in the right manner or with the necessary amount of detail to make the comparisons meaningful. This article discusses the need for effective cost analysis of test strategies and highlights some of the pitfalls. 相似文献
9.
10.
We describe a decision support system to distinguish among hematology cases directly from microscopic specimens. The system
uses an image database containing digitized specimens from normal and four different hematologic malignancies. Initially,
the nuclei and cytoplasmic components of the specimens are segmented using a robust color gradient vector flow active contour
model. Using a few cell images from each class, the basic texture elements (textons) for the nuclei and cytoplasm are learned,
and the cells are represented through texton histograms. We propose to use support vector machines on the texton histogram
based cell representation and achieve major improvement over the commonly used classification methods in texture research.
Experiments with 3,691 cell images from 105 patients which originated from four different hospitals indicate more than 84%
classification performance for individual cells and 89% for case based classification for the five class problem.
相似文献
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