Qualitative features of matrix pencils and DAEs arising in circuit dynamics

The dynamical behaviour of nonlinear electrical circuits is usually modelled in the time domain by differential-algebraic equations (DAEs). The differential-algebraic formalism drives qualitative analyses based on linearization to a matrix pencil setting. In this context, the present paper performs a spectral analysis of matrix pencils and DAEs arising in nonlinear circuit theory. Specifically, the non-singularity, hyperbolicity and asymptotic stability of equilibria are addressed in terms of circuit topology. The differential-algebraic framework puts the results beyond those already known for state-space models, unfeasible in many actual problems. The topological conditions arising in this qualitative study are proved independent of those supporting the index, and therefore they apply to both index-1 and index-2 configurations. The approach illustrates how graph theory, matrix analysis and DAE theory interact in the dynamical study of nonlinear circuits.     

On the stability of solutions of autonomous index-I tractable and quasilinear index-2 tractable DAEs

Conclusion We have seen that the stationary solutions of the regularized equations are asymptotically stable if the stationary solution of the original quasilinear index-2 tractable DAE is so. In other words, the given regularizations supply a solution sharing the stability properties of the solution of the unperturbed equation.     

Effect of Ni and SAPO-34 co-additive on enhancing hydrogen storage performance of MgH2

The hydrogen storage performances of MgH₂ improved by the addition of Ni and SAPO-34 were studied in detail. The mixture of MgH₂ with Ni and SAPO-34 was a physical reaction as shown by the X-ray diffraction (XRD) results. The SAPO-34 and Ni were uniformly distributed on the surface of MgH₂. The thermodynamic and kinetic properties of 90MgH₂/5Ni/5SAPO-34 were investigated by differential scanning calorimetry (DSC) and pressure-composition-isothermal (PCI) methods. The results showed that the dehydrogenation activation energy of 90MgH₂/5Ni/5SAPO-34 decreased by 64.3 kJ/mol compared with that of MgH₂. In addition, the relationship between the value of dehydrogenation heat and hydrogen content was also investigated by in-situ calorimetry. The enthalpy value of each sample in the dehydrogenation processes were calculated by in-situ calorimetry measurement. The dehydrogenation enthalpies of as-milled MgH₂ and 90MgH₂/5Ni/5SAPO-34 were 63.2 kJ/mol H₂ and 53.6 kJ/mol H₂, respectively. Thus, the co-doping of Ni and SAPO-34 contributed significantly to decrease the thermodynamic stability and improve the hydrogen sorption kinetic properties of MgH₂.     

Using MCRDR based Agile approach for expert system development

Various expert system development approaches were proposed but most of them cannot deal with two problems: the difficulty of analysis and maintenance. Rather than to spend time waiting any longer, it is better to find an alternative solution from other research fields. In computer software development area, researchers have been suffering from the difficulty of maintenance and analysis, just as the researchers in the expert system development field. To solve this issue, researchers in the software used both agile software development and business rules approach: agile software development is for overcoming the the difficulty of analysis, and business rules approach is for reducing issues in the maintenance. There is a big opportunity that those two approaches can also be solve the two issues in the expert system development field. The paper describes requirements of the approach based on agile software development and the business rules approach. As a result, we consider and specify why the Multiple Classification Ripple Down Rules is the novel approach for the expert system development.     

NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases

Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neurons from neonatal rat trigeminal ganglia—a locus for craniofacial sensory nerves—were used to examine how NGF affects the Ca²⁺-dependent release of a pain mediator, calcitonin gene-related peptide (CGRP), that is triggered by activating a key signal transducer, transient receptor potential vanilloid 1 (TRPV1) with capsaicin (CAP). Measurements utilised neurons fed with or deprived of NGF for 2 days. Acute re-introduction of NGF induced Ca²⁺-dependent CGRP exocytosis that was inhibited by botulinum neurotoxin type A (BoNT/A) or a chimera of/E and/A (/EA), which truncated SNAP-25 (synaptosomal-associated protein with Mr = 25 k) at distinct sites. NGF additionally caused a Ca²⁺-independent enhancement of the neuropeptide release evoked by low concentrations (<100 nM) of CAP, but only marginally increased the peak response to ≥100 nM. Notably, BoNT/A inhibited CGRP exocytosis evoked by low but not high CAP concentrations, whereas/EA effectively reduced responses up to 1 µM CAP and inhibited to a greater extent its enhancement by NGF. In addition to establishing that sensitisation of sensory neurons to CAP by NGF is dependent on SNARE-mediated membrane fusion, insights were gleaned into the differential ability of two regions in the C-terminus of SNAP-25 (181–197 and 198–206) to support CAP-evoked Ca²⁺-dependent exocytosis at different intensities of stimulation.     

Semistate models of electrical circuits including memristors

In this paper we present several semistate or differential‐algebraic models arising in nodal analysis of nonlinear circuits including memristors. The goal is to characterize the tractability index of these models under strict passivity assumptions, a key issue for the numerical simulation of circuit dynamics. We show that the main model, which combines memristors' fluxes and charges, is index two. From a technical point of view, this result is based on the use of a projector along the image of the leading matrix, in contrast to previous index analyses. For charge‐controlled memristors, the elimination of fluxes yields an index one system in topologically nondegenerate circuits, and an index two model otherwise. Analogous results are also proved to hold for flux‐controlled memristors. Our framework accommodates coupling effects among resistors, memristors, capacitors and inductors. Copyright © 2010 John Wiley & Sons, Ltd.     

Impact of managed care on independent practice and professional ethics: A survey of independent practitioners.

Managed care significantly affects the service delivery patterns, business structures, ethics, and professional concerns of independent practitioners. This survey assessed psychologists' perceptions of the effects of managed care on practice and ethics. Most respondents reported significant increases in dependence on managed care services for income. Negative effects included loss of control over ethical decisions and potential harm to patients from erosion of confidentiality. A majority of respondents reported encountering ethical concerns not addressed by the American Psychological Association ethics code. Findings suggest directions for practice development, for public policy addressing confidentiality, and for clarification of ethical responsibilities. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Structural analysis of electric circuits and consequences for MNA

The development of integrated circuits requires powerful numerical simulation programs. Naturally, there is no method that treats all the different kinds of circuits successfully. The numerical simulation tools provide reliable results only if the circuit model meets the assumptions that guarantee a successful application of the integration software. Owing to the large dimension of many circuits (about 10⁷ circuit elements) it is often difficult to find the circuit configurations that lead to numerical difficulties. In this paper, we analyse electric circuits with respect to their structural properties in order to give circuit designers some help for fixing modelling problems if the numerical simulation fails. We consider one of the most frequently used modelling techniques, the modified nodal analysis (MNA), and discuss the index of the differential algebraic equations (DAEs) obtained by this kind of modelling. Copyright © 2000 John Wiley & Sons, Ltd.     

What we know about offenders who drive under the influence: analysis of court case file reviews

This paper presents findings from a quantitative study about alcohol-impaired drivers in Utah. The University of Utah's Social Research Institute conducted a retrospective case file evaluation about the adjudication and sanctioning phases associated with driving under the influence (DUI) to determine Utah's response to DUI crime from arrest forward. Although Utah driver's license and court systems are on the cutting edge of dealing with DUI offenders, we found a variety of limitations for analysis due to data collection and entry. Therefore, it is difficult to develop a thorough understanding about the process of dealing with DUI offenders and the effectiveness of court actions and treatments. The purpose of this paper is to provide recommendations about how to ensure more accurate data collection about impaired drivers.     

DXP Synthase‐Catalyzed C?N Bond Formation: Nitroso Substrate Specificity Studies Guide Selective Inhibitor Design

1‐Deoxy‐D ‐xylulose 5‐phosphate (DXP) synthase catalyzes the first step in the nonmammalian isoprenoid biosynthetic pathway to form DXP from pyruvate and D ‐glyceraldehyde 3‐phosphate (D ‐GAP) in a thiamin diphosphate‐dependent manner. Its unique structure and mechanism distinguish DXP synthase from its homologues and suggest that it should be pursued as an anti‐infective drug target. However, few reports describe any development of selective inhibitors of this enzyme. Here, we reveal that DXP synthase catalyzes C? N bond formation and exploit aromatic nitroso substrates as active site probes. Substrate specificity studies reveal a high affinity of DXP synthase for aromatic nitroso substrates compared to the related ThDP‐dependent enzyme pyruvate dehydrogenase (PDH). Results from inhibition and mutagenesis studies indicate that nitroso substrates bind to E. coli DXP synthase in a manner distinct from that of D ‐GAP. Our results suggest that the incorporation of aryl acceptor substrate mimics into unnatural bisubstrate analogues will impart selectivity to DXP synthase inhibitors. As a proof of concept, we show selective inhibition of DXP synthase by benzylacetylphosphonate (BnAP).