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排序方式: 共有86条查询结果,搜索用时 0 毫秒
1.
Chapuis Y-A. Lingfei Zhou Fukuta Y. Mita Y. Fujita H. 《Industrial Electronics, IEEE Transactions on》2007,54(4):1926-1936
In this paper, the authors have developed and implemented a decentralized decision-making strategy using field-programmable gate array (FPGA) technology as a prototype for an integrated controller of a microelectromechanical systems (MEMS) array for air-flow planar micromanipulation. The MEMS array was proposed to be integrated in a hybrid multichip module containing the FPGA-based controller. Algorithms and architectures, used for the decentralized control implementation and the hardware resource optimization, are described. A charge-coupled device camera was used to make each MEMS like an autonomous system when the distributed MEMS chip was tested. Finally, under air-flow condition, the FPGA-based decentralized control system successfully performed an object manipulation. 相似文献
2.
Accurate road following and reconstruction by computer vision 总被引:1,自引:0,他引:1
Chapuis R. Aufrere R. Chausse F. 《Intelligent Transportation Systems, IEEE Transactions on》2002,3(4):261-270
This paper presents a method designed to track and to recover the three-dimensional (3-D) shape of a road by computer vision. The method is based first upon an accurate detection algorithm which provides a reliable estimation of the roadside in the image. This algorithm works by recursive updating of a statistical model of the lane obtained by an off-line training phase. Once the sides have been located, a reconstruction algorithm computes the vehicle location on its lane, the 3-D shape of the road, and gives both the sides location and their confidence interval for the next image. The detection algorithm then looks for the roadside in this interval in order to limit the computational times, which are about 30-150 ms on a HP workstation. 相似文献
3.
4.
Joris Lacroix Sandrine Pélofy Charline Blatché Marie‐Jeanne Pillaire Sébastien Huet Catherine Chapuis Jean‐Sébastien Hoffmann Aurélien Bancaud 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(43):5963-5970
DNA replication is essential to maintain genome integrity in S phase of the cell division cycle. Accumulation of stalled replication forks is a major source of genetic instability, and likely constitutes a key driver of tumorigenesis. The mechanisms of regulation of replication fork progression have therefore been extensively investigated, in particular with DNA combing, an optical mapping technique that allows the stretching of single molecules and the mapping of active region for DNA synthesis by fluorescence microscopy. DNA linearization in nanochannels has been successfully used to probe genomic information patterns along single chromosomes, and has been proposed to be a competitive alternative to DNA combing. Yet this conjecture remains to be confirmed experimentally. Here, two complementary techniques are established to detect the genomic distribution of tracks of newly synthesized DNA in human cells by optical mapping in nanochannels. Their respective advantages and limitations are compared, and applied them to detect deregulations of the replication program induced by the antitumor drug hydroxyurea. The developments here thus broaden the field of applications accessible to nanofluidic technologies, and can be used in the future as part for molecular diagnostics in the context of high throughput cancer drug screening. 相似文献
5.
Gervais Chapuis 《Crystallography Reviews》2013,19(2):109-128
Abstract Modulated structures can be found in organic, inorganic and even quasicrystalline structures. They are generally detected by diffraction from the presence of satellites surrounding the Bragg reflections. Their positions may vary continuously with temperature or pressure so that the phase can be considered as incommensurately modulated. Incommensurate phases usually transform to a periodic high symmetry phase by increasing temperature and to a commensurate lock-in phase by lowering the temperature. Their domain of stability varies with temperature, pressure and with the type of compound. Examples have been identified where the interval of equilibrium vary from a few tenths to a few hundreds of degrees. Recent progress in the field of incommensurate structure analysis has been greatly favoured by the superspace group approach which is now almost exclusively applied. In many cases, the resolution of the modulated phases by diffraction methods has contributed towards the understanding of the phase changes. In addition, microscopic models for the transition mechanisms have been developed to understand small organic systems. The methods of molecular dynamics have been able to explain the formation of various sequences of commensurate and incommensurate phases observed experimentally. 相似文献
6.
Robert P. Chapuis 《Bulletin of Engineering Geology and the Environment》2009,68(3):387-395
As monitoring wells (MWs) in clay layers have a time lag of weeks or months, the piezometric level (PL) at a given time is
difficult to assess. For time lag problems due to external loadings, Hvorslev provided solutions depending on the clay saturated
hydraulic conductivity, k, but not on its specific storage S
s. This paper examines natural conditions rather than external loading and reports some practical examples using the finite
element method. When the hydraulic heads in the upper and lower aquifers are initially constant and then change rapidly at
the same time to take new constant values, the time lag is shown to depend on both k and S
s and the MW gives the correct PL after several weeks. This time lag largely exceeds that obtained following Hvorslev. When
the aquifer heads vary with time, which is the usual case, the water level in the pipe is never a PL and any extrapolation
of water level versus time gives an unreliable prediction of the PL.
相似文献
7.
This paper reviews analytical solutions for steady state seepage of groundwater in an ideal sloping unconfined aquifer, recharged
by an effective infiltration, when the unsaturated seepage is neglected. Available solutions are examined and compared. Their
robustness is assessed with a finite element code, which solves the complete equations for saturated and unsaturated flow,
thus making none of the simplifying assumptions of the theoretical solutions. An example is provided for a sloping aquifer
on the north shore of the Saint-Lawrence River. 相似文献
8.
The results of donor lymphocyte infusion (DLI) for treatment of relapse after bone marrow transplantation (BMT) are reviewed. Durable complete remission can be achieved at the molecular level for a majority (more than 70%) of patients with CML, when treated at early relapse. Results are less favourable for acute leukemias, although useful responses have been reported. Data are scarce though promising for myelodysplastic syndromes and multiple myeloma. Major treatment-associated toxicities are GVHD and bone marrow aplasia. The latter complication can be predicted by evaluating the level of residual donor-derived hematopoiesis. Modification of infused cells (CD8 negative selection or transduction with a suicide gene), addition of peripheral blood stem cells, and early implementation of escalating doses may counteract the complications and increase the response rate. Response rate is variably influenced by the presence of chronic GVHD after initial BMT, T-cell depleted BMT, underlying disease and stage at relapse, and the level of mixed chimerism. DLI is a direct demonstration of the graft-versus-leukemia effect (GVL). Because GVL after BMT is sometimes the predominant cause of cure, it may be advisable in such situations to redirect the conditioning regimens for BMT towards engraftment and less immediate cytotoxicity. 相似文献
9.
N Rufer E Wolpert C Helg JM Tiercy A Gratwohl B Chapuis M Jeannet E Goulmy E Roosnek 《Canadian Metallurgical Quarterly》1998,66(7):910-916
BACKGROUND: Allogeneic bone marrow donors can be incompatible at different levels. Even HLA-identical pairs will be still incompatible for numerous minor histocompatibility antigens (mHag). Nevertheless, some incompatibilities are found to be associated with an increased risk of graft-versus-host disease (GVHD), which could be related to the way the immune system recognizes these antigens. METHODS: We determined the specificity of cytotoxic T-cell clones isolated during acute GVHD or during bone marrow graft rejection in patients (n=14) transplanted with marrow from donors who were histoincompatible for different minor and/or major histocompatibility antigens. RESULTS: We found a clear hierarchy among the different types of histoincompatibilities. In three combinations mismatched for a class I allele, all 27 clones isolated during GVHD were specific for the incompatible HLA molecule. In the 11 class I-identical combinations, 14 different mHags were recognized. The mHag HA-1, known to have a significant impact on the development of GVHD, was recognized in the two HA-1-incompatible combinations. In one of these combinations, which was sex mismatched, all 56 clones analyzed were directed against HA-1, demonstrating the dominance of this mHag. In the four HA-1-compatible, sex-mismatched combinations, the anti-H-Y response was directed against one immunodominant epitope rather than against multiple Y-chromosome-encoded epitopes. All male specific cytotoxic T lymphocytes (n=15) recognized the same high-performance liquid chromatography-purified peptide fraction presented by T2 cells. Moreover, all cytotoxic T lymphocytes tested (n=6) were specific for the SMCY-derived peptide FIDSYICQV, originally described as being the H-Y epitope recognized in the context of HLA-A*0201. CONCLUSIONS: Some histocompatibility antigens are recognized in an immunodominant fashion and will therefore be recognized in the majority of mismatched combinations. Only for such antigens, correlations between mismatches and the occurrence of GVHD or graft rejections will be found. 相似文献
10.
Jonas Chapuis Alexander Schramm Ion Pappas Wock Hallermann Katja Schwenzer-Zimmerer Frank Langlotz Marco Caversaccio 《IEEE transactions on information technology in biomedicine》2007,11(3):274-287
A new system for computer-aided corrective surgery of the jaws has been developed and introduced clinically. It combines three-dimensional (3-D) surgical planning with conventional dental occlusion planning. The developed software allows simulating the surgical correction on virtual 3-D models of the facial skeleton generated from computed tomography (CT) scans. Surgery planning and simulation include dynamic cephalometry, semi-automatic mirroring, interactive cutting of bone and segment repositioning. By coupling the software with a tracking system and with the help of a special registration procedure, we are able to acquire dental occlusion plans from plaster model mounts. Upon completion of the surgical plan, the setup is used to manufacture positioning splints for intraoperative guidance. The system provides further intraoperative assistance with the help of a display showing jaw positions and 3-D positioning guides updated in real time during the surgical procedure. The proposed approach offers the advantages of 3-D visualization and tracking technology without sacrificing long-proven cast-based techniques for dental occlusion evaluation. The system has been applied on one patient. Throughout this procedure, we have experienced improved assessment of pathology, increased precision, and augmented control. 相似文献