Detection of laryngeal function using speech andelectroglottographic data

The purpose of this research was to develop quantitative measures for the assessment of laryngeal function using speech and electroglottographic (EGG) data. We developed two procedures for the detection of laryngeal pathology: 1) a spectral distortion measure using pitch synchronous and asynchronous methods with linear predictive coding (LPC) vectors and vector quantization (VQ) and 2) analysis of the EGG signal using time interval and amplitude difference measures. The VQ procedure was conjectured to offer the possibility of circumventing the need to estimate the glottal volume velocity wave-form by inverse filtering techniques. The EGG procedure was to evaluate data that was "nearly" a direct measure of vocal fold vibratory motion and thus was conjectured to offer the potential for providing an excellent assessment of laryngeal function. A threshold based procedure gave 75.9 and 69.0% probability of pathological detection using procedures 1) and 2), respectively, for 29 patients with pathological voices and 52 normal subjects. The false alarm probability was 9.6% for the normal subjects.     

Scheduling with dynamic voltage/speed adjustment using slack reclamation in multiprocessor real-time systems

The high power consumption of modern processors becomes a major concern because it leads to decreased mission duration (for battery-operated systems), increased heat dissipation, and decreased reliability. While many techniques have been proposed to reduce power consumption for uniprocessor systems, there has been considerably less work on multiprocessor systems. In this paper, based on the concept of slack sharing among processors, we propose two novel power-aware scheduling algorithms for task sets with and without precedence constraints executing on multiprocessor systems. These scheduling techniques reclaim the time unused by a task to reduce the execution speed of future tasks and, thus, reduce the total energy consumption of the system. We also study the effect of discrete voltage/speed levels on the energy savings for multiprocessor systems and propose a new scheme of slack reservation to incorporate voltage/speed adjustment overhead in the scheduling algorithms. Simulation and trace-based results indicate that our algorithms achieve substantial energy savings on systems with variable voltage processors. Moreover, processors with a few discrete voltage/speed levels obtain nearly the same energy savings as processors with continuous voltage/speed, and the effect of voltage/speed adjustment overhead on the energy savings is relatively small.     

Modeling the effects of hypoglycemia on a two-choice task in adult humans.

Objective: Previous research has demonstrated that hypoglycemia causes reaction times to be slower and more variable. Reaction time tests, however, use multiple cognitive and noncognitive processes. This study is the first to use a validated sequential sampling model (diffusion model) applied to results obtained from a simple 2-choice task in adult humans to assess the effects of hypoglycemia on the basic parameters of decision making. Method: Fourteen adult volunteers were tested on a numerosity discrimination task with and without reduced blood glucose concentrations. The results were analyzed with a model that dissects the components of processing that underlie decisions: the quality of the information on which a decision is based (drift rate), the critical amount of evidence that must be accumulated before a decision is made (boundary separation), and the time taken by nondecision processes. Results: Hypoglycemia resulted in a reduction of mean drift rate from 0.290 to 0.211, t(13) = 4.10, p     

Multichannel, Single Tral Event Related Potential Classification

We report on the effect of electrode placement and number of electrodes on the classification of single trial event related potentials (ERP's). The subjects read propositions relating fictitious people and their occupations while ERP's were recorded. The subjects decided if the proposition was correct or incorrect and responded as per instructions. The single trial, multichannel ERP data were classified using various methods, e. g., hold-out, leave-one-out, resubstitution. Several other factors were examined to determine their effect on ERP classification, including taking a majority vote among channels, using the single best channel, and averaging the data across channels for a single ERP. The results from other experiments are compared to those presented here.     

Speech processing and synthesis for assessing vocal disorders

Techniques for the quantitative assessment and classification of vocal disorders are described. Models for vocal disorders using speech synthesis are examined. Methods for characterizing the electroglottography (EGG) waveform and the assessment of vocal quality using acoustic and EGG signal features are discussed.     

A Stackable Bonding-Free Flextensional Piezoelectric Actuator

A flextensional actuator was designed using commercial multilayer stacked actuator so as to produce large displacements at intermediate force levels. The simple design chosen eliminated the need for bonding the actuators into the frame and permitted easy series connection of multiple units. To satisfy the need for a fiber grating tuning device to interrogate an array of Bragg grating fiber optic stress sensors, a tuning device using four series connected units was constructed. The unit performs well, but the actual measured amplification is less than theoretical expectation. The problem was traced to unwanted flexing of the simple original frame and a hinged more robust flexing beam construction was shown to eliminate the problem.     

Opioid receptor-coupled G-proteins in rat locus coeruleus membranes: decrease in activity after chronic morphine treatment

The nucleus locus coeruleus is involved in the expression of opiate physical dependence and withdrawal, and has been characterized extensively with regard to chronic morphine-induced alterations in biochemical and electrophysiological responses. In the present study the effects of chronic morphine treatment on opioid receptor-coupled G-protein activity was investigated in membranes from rat locus coeruleus. Opioid agonists stimulated low Km GTPase activity with pharmacology consistent with mu receptors. Chronic morphine treatment resulted in decreases in both basal and opioid-stimulated low Km GTPase activity, with no change in the percent stimulation by agonist. The decrease in low Km GTPase activity appeared to be due to a decrease in the Vmax of the enzyme, with no change in the Km for GTP hydrolysis. These results were confirmed by assays of basal and opioid receptor-stimulated [35S]GTP gamma S binding in the presence of excess GDP. Thus, chronic morphine treatment apparently decreased inhibitory G-protein activity in the locus coeruleus without producing any detectable desensitization. These results suggest a potential adaptation at the receptor/transducer level which may contribute to other biochemical changes produced in the locus coeruleus by chronic morphine treatment.     

Occupant posture analysis with stereo and thermal infrared video: algorithms and experimental evaluation

Dynamic analysis of vehicle occupant posture is a key requirement in designing "smart airbag" systems. Vision-based technology could enable the use of precise information about the occupant's size, posture, and, in particular, position in making airbag-deployment decisions. Novel sensory systems and algorithms need to be developed for capture, analysis, and classification of dynamic video-based information for a new generation of safe airbags. This paper presents a systematic investigation in which stereo and thermal long-wavelength infrared video-based real-time vision systems are developed and systematically evaluated. It also includes the design of several test beds, including instrumented vehicles for systematic experimental studies for the evaluation of independent and comparative evaluation in automobiles. Results of extensive experimental trials suggest basic feasibility of stereo and thermal long-wavelength infrared video-based occupant position and posture-analysis system.