Examining the role of perceived value in virtual communities continuance: its antecedents and the influence of experience

Although perceived value has long been recognised as an influential means of affecting continuance intention in information systems (IS), little attention has been devoted to explore its antecedents, which constitutes an important research issue. This study, building on prior literature on continued usage in IS as well as the resource-based view, proposed a model to address this gap. Our model suggests that perceived value, a major driving force for members’ satisfaction and continuance intention, is affected by four kinds of resources embedded in virtual communities, which are relationship resources, technology infrastructure, knowledge resources and human resources. To provide additional insights on the pivotal role of perceived value, we also postulate that experience moderates the link between perceived value and its antecedents. Data collected from 235 members of a professional virtual community provide strong support for the research model. It was found that perceived value exerts a great effect on both satisfaction and continuance intention. In addition, when different levels of experience are taken into consideration, relationship resources, knowledge resources and human resources were found to be more salient to high-experience members, whereas technology infrastructure was found to be more salient to low-experience members. Finally, this study discusses the implications of these findings and offers direction for future research.     

基于区分类别能力的高性能特征选择方法

特征选择在文本分类中起着重要作用.文档频率(document frequency,简称DF)、信息增益(informationgain,简称IG)和互信息(mutualin formation,简称MI)等特征选择方法在文本分类中广泛应用.已有的实验结果表明,IG是最有效的特征选择算法之一,DF稍差,而MI效果相对较差.在文本分类中,现有的特征选择函数性能的评估均是通过实验验证的方法,即完全是基于经验的方法.特征选择是选择部分最有区分类别能力的特征,为此,给出了两个特征选择函数需满足的基本约束条件,并提出了一种构造高性能特征选择的通用方法.依此方法构造了一个新的特征选择函数KG(knowledge gain).分析发现,IG和KG完全满足该构造方法,在Reuters-21578,OHSUMED和News Group这3个语料集上的实验表明,IG和KG性能最好,在两个语料集上,KG甚至超过了IG.验证了提出的构造高性能特征选择函数方法的有效性,同时也在理论上给出了一个评价高性能特征选择算法的标准.     

Collision and intersection detection of two ruled surfaces using bracket method

Collision and intersection detection of surfaces is an important problem in computer graphics and robotic engineering. A key idea of our paper is to use the bracket method to derive the necessary and sufficient conditions for the collision of two ruled surfaces. Then the numerical intersection curve can be characterized. The cases for two bounded ruled surfaces are also discussed.     

Proteomics integrated with Escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of Propionibacterium acnes

Proteomics is a powerful tool for the identification of proteins, which provides a basis for rational vaccine design. However, it is still a highly technical and time‐consuming task to examine a protein's immunogenicity utilizing traditional approaches. Here, we present a platform for effectively evaluating protein immunogenicity and antibody detection. A tetanus toxin C fragment (Tet‐c) was used as a representative antigen to establish this platform. A cell wall‐anchoring sialidase‐like protein (SLP) of Propionibacterium acnes was utilized to assess the efficacy of this platform. We constructed an Escherichia coli vector‐based vaccine by overexpressing Tet‐c or SLP in E. coli and utilized an intact particle of E. coli itself as a vaccine (E. coli Tet‐c or SLP vector). After ultraviolet (UV) irradiation, the E. coli vector‐based vaccines were administered intranasally into imprinting control region mice without adding exogenous adjuvants. For antibody detection, we fabricated antigen microarrays by printing with purified recombinant proteins including Tet‐c and SLP. Our results demonstrated that detectable antibodies were elicited in mice 6 weeks after intranasal administration of UV‐irradiated E. coli vector‐based vaccines. The antibody production of Tet‐c and SLP was significantly elevated after boosting. Notably, the platform with main benefits of using E. coli itself as a vaccine carrier provides a critical template for applied proteomics aimed at screening novel vaccine targets. In addition, the novel immunogenic SLP potentially serves as an antigen candidate for the development of vaccines targeting P. acnes‐associated diseases.     

利用HyperChem获取反应过渡态的方法

利用HyperChem的动态数据交换DDE(Dynamic Data Exchange)功能，通过Excel中的Visual BasicA编程来控制HyperChem的运行，从而控制反应过程中的反应坐标和反应步长，计算得到反应系统沿反应坐标的能量变化曲线，从而可获取反应的过渡态和活化能△E。利用该计算方法搜寻了喹啉分子在S-Mo-Ni催化剂晶体表面催化加氢反应的过渡态，取得较好的效果。利用该方法可以确定复杂反应过渡态，从而为实验研究起理论指导作用。     

Conversion of hydrogen/carbon dioxide into formic acid and methanol over Cu/CuCr2O4 catalyst

Cu/CuCr₂O₄ catalysts were prepared by impregnation method at various calcination temperatures (300, 400, and 500 °C) and then reduced in H₂ stream. The aggregated particles and decreasing surface area/pore volumes of the deactivated catalysts during HCOOH and CH₃OH formations were also observed. Particularly, the EXAFS data showed that first shells of Cu atoms transforms from Cu–O to Cu–Cu after catalytic reactions, their bond distances and coordination numbers are quite different, respectively. It revealed that metallic Cu atoms are one of the important active species over catalyst surface at different reaction temperatures having many unoccupied binding sites for HCOOH and CH₃OH formations. Additionally, the optimal calcination temperature for Cu/CuCr₂O₄ catalysts was demonstrated at 400 °C that attributed to its strongest acidity and basicity. The catalytic reactions in the duration of HCOOH and CH₃OH preparation were proposed that were composed of HCOOH formation, CH₃OH formation, and CH₃OH decomposition happening at CuCr₂O₄, Cu, and CuO active sites, respectively. The highest CO₂ conversion (14.6%), HCOOH selectivity/yield (87.8/12.8%), and TON/TOF values (4.19/0.84) were obtained at 140 °C and 30 bar in 5 h, respectively. Optimal rate constant (2.57 × 10^?2 min^?1) and activation energy (16.24 kJ mol^?1) of HCOOH formation were evaluated by pseudo first-order model and Arrhenius equation, respectively.     

Squamosamide Derivative FLZ Protects Retinal Pigment Epithelium Cells from Oxidative Stress through Activation of Epidermal Growth Factor Receptor (EGFR)-AKT Signaling

Reactive oxygen species (ROS)-mediated retinal pigment epithelium (RPE) cell apoptosis is attributed to age-related macular degeneration (AMD) pathogenesis. FLZ, a novel synthetic squamosamide derivative from a Chinese herb, Annona glabra, has displayed significant cyto-protective activity. In the current study, we explored the pro-survival effect of FLZ in oxidative stressed-RPE cells and studied the underlying signaling mechanisms. Our results showed that FLZ attenuated hydrogen peroxide (H₂O₂)-induced viability decrease and apoptosis in the RPE cell line (ARPE-19 cells) and in primary mouse RPE cells. Western blotting results showed that FLZ activated AKT signaling in RPE cells. The AKT-specific inhibitor, MK-2206, the phosphoinositide 3-kinase (PI3K)/AKT pan inhibitor, wortmannin, and AKT1-shRNA (short hairpin RNA) depletion almost abolished FLZ-mediated pro-survival/anti-apoptosis activity. We discovered that epidermal growth factor receptor (EGFR) trans-activation mediated FLZ-induced AKT activation and the pro-survival effect in RPE cells, and the anti-apoptosis effect of FLZ against H₂O₂ was inhibited by the EGFR inhibitor, PD153035, or by EGFR shRNA-knockdown. In conclusion, FLZ protects RPE cells from oxidative stress through activation of EGFR-AKT signaling, and our results suggest that FLZ might have therapeutic values for AMD.     

点目标的红外辐射特性测量方法

首先给出了红外辐射特性测量的基本原理,对于点目标,由于光学系统的衍射作用,经过光学系统成像为一个弥散斑,由于弥散的原因,点目标的辐射特性测量精度一般都非常低,针对这种情况,提出了一种基于辐射能量守恒的点目标辐射特性测量优化算法,给出了算法的具体原理和实现过程;最后,为了验证算法的有效性,在实验室里利用平行光管和点目标模拟装置进行了点目标辐射特性测量实验,并对试验结果进行了系统分析,结果表明,经过优化算法后,点目标的辐射测量精度优于10%,表明点目标辐射特性测量优化算法在实际应用中有很广泛的前景.     

Significantly enhanced dc electrical resistivity and piezoelectric properties of Tb-modified CaBi2Nb2O9 ceramics for high-temperature piezoelectric applications

Bismuth layer–structured ferroelectric calcium bismuth niobate (CaBi₂Nb₂O₉, CBN) is considered to be one of the most potential high-temperature piezoelectric materials due to its high Curie temperature T_c of ∼940°C, but the drawbacks of low electrical resistivity at elevated temperature and low piezoelectric performance limit its applications as key electronic components at high temperature (HT). Herein, we report significantly enhanced dc electrical resistivity and piezoelectric properties of CBN ceramics through rare-earth element Tb ions compositional adjustment. The nominal compositions of Ca_1−xTb_xBi₂Nb₂O₉ (abbreviated as CBN-100xTb) have been fabricated by conventional solid-state reaction method. The composition of CBN-3Tb exhibits a significantly enhanced dc electrical resistivity of 1.97 × 10⁶ Ω cm at 600°C, which is larger by two orders of magnitude compared with unmodified CBN. The donor substitutions of Tb³⁺ ions for Ca²⁺ ions reduce the oxygen vacancy concentrations and increase the band-gap energy, which is responsible for the enhancement of dc electric resistivity. The temperature-dependent dc conduction properties reveal that the conduction is dominated by the thermally activated oxygen vacancies in the low-temperature region (200–350°C) and by the intrinsic conduction in the HT region (350–650°C). The CBN-3Tb also exhibits enhanced piezoelectric properties with a high piezoelectric coefficient d₃₃ of ∼13.2 pC/N and a high T_c of ∼966°C. Moreover, the CBN-3Tb exhibits good thermal stabilities of piezoelectric properties, remaining 97% of its room temperature value after annealing at 900°C. These properties demonstrate the great potentials of Tb-modified CBN for high-temperature piezoelectric applications.