Frequency-Doubled Fiber Lasers for RF Spectrum Analysis in Spectral-Hole-Burning Media

We demonstrate an RF spectrum analyzer based on spectral-hole burning (SHB) that operates with unity probability of intercept and resolution under 100 kHz. An SHB crystal, which consists of rare-earth ions doped into a crystal host, records the power spectrum of an RF signal modulated onto an optical carrier as a series of spectral holes that persist for about 10 ms. While the crystal's homogeneous and inhomogeneous linewidths place the fundamental limits on resolution and bandwidth, respectively, the practical limits depend on the lasers used to interrogate the record stored in the crystal's absorption profile. Up to now, SHB spectrum analyzers have used chirped beams from externally modulated, stabilized lasers, which have linewidths of under 10 kHz but cannot chirp over much more than octave bandwidths, or directly modulated diode lasers, which can chirp over more than 20GHz but have linewidths of about 1 MHz. Switching to chirped fiber lasers, which have natural linewidths of under 2 kHz and chirping linewidths on the order of 10 kHz, produces a measurement with fine resolution without any laser stabilization. In addition, by chirping the fiber laser with a sufficiently fast piezo, the resulting chirp could extend over tens of gigahertz in under 10 ms, yielding both fine resolution and broad bandwidth without extraordinary stabilization schemes.     

Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial

BACKGROUND/AIMS: Fulminant hepatic failure (FHF) is usually fatal without liver transplantation. Auxiliary heterotopic partial liver transplantation (AHPLT) may offer advantages over orthotopic liver transplantation (OLT) or any other heterotopic procedure for the treatment of patients with fulminant liver failure. We studied AHPLT in a severe acute hepatic failure model in pigs. METHODOLOGY: Group A (control: n = 5) underwent portal vein and hepatic artery ligation and side-to-side portocaval shunting. Group B (AHPLT: n = 15) underwent host portal vein and hepatic artery ligation and AHPLT. RESULTS: All of the pigs in group A died within 48 hours from massive liver necrosis. Ten of the 15 pigs (67%) in group B had well-functioning grafts. Five of these ten died between 8 and 17 days postoperatively due to various complications. The remaining five survived for sixty days postoperatively in healthy condition. At the time of sacrifice, four of these five had well-functioning grafts weighing 739 +/- 52 g (mean +/- SEM) and regenerated, but still atrophied, host livers weighing 262 +/- 23 g (p < 0.0002). On the other hand, the one remaining pig had an atrophied graft weighing 310 g and a well-regenerated host liver weighing 470 g, probably due to a late, poorly functioning graft associated with severe rejection. CONCLUSION: AHPLT may result in survival despite host hepatic failure, and the host liver may recover within two months, despite total interruption of blood inflow.     

Broadband radio-frequency spectrum analysis in spectral-hole-burning media

We demonstrate a 20 GHz spectrum analyzer with 1 MHz resolution and >40 dB dynamic range using spectral-hole-burning (SHB) crystals, which are cryogenically cooled crystal hosts lightly doped with rare-earth ions. We modulate a rf signal onto an optical carrier using an electro-optic intensity modulator to produce a signal beam modulated with upper and lower rf sidebands. Illuminating SHB crystals with modulated beams excites only those ions resonant with corresponding modulation frequencies, leaving holes in the crystal's absorption profile that mimic the modulation power spectrum and persist for up to 10 ms. We determine the spectral hole locations by probing the crystal with a chirped laser and detecting the transmitted intensity. The transmitted intensity is a blurred-out copy of the power spectrum of the original illumination as mapped into a time-varying signal. Scaling the time series associated with the transmitted intensity by the instantaneous chirp rate yields the modulated beam's rf power spectrum. The homogeneous linewidth of the rare-earth ions, which can be <100 kHz at cryogenic temperatures, limits the fundamental spectral resolution, while the medium's inhomogeneous linewidth, which can be >20 GHz, determines the spectral bandwidth.     

Holographic method of cohering fiber tapped delay lines

We propose, analyze, and demonstrate the use of a holographic method for cohering the output of a fiber tapped delay line (FTDL) that enables the use of fiber-remote optical modulators in coherent optical processing systems. We perform a theoretical examination of the phase-cohering process and show experimental results for a radio frequency (RF) spectrum analyzer that uses a lens to spatially Fourier transform the output of a holographically phase-cohered FTDL providing 50 MHz resolution and bandwidths approaching 3 GHz. Substantial improvements in bandwidth should be achievable with better fiber length-trimming accuracy and improvements in resolution can be obtained with longer fiber delay lines. We also analyze and demonstrate the use of a parallel holographic technique that compensates for polarization state scrambling induced by propagation through an array of single-mode fibers. Both the phase-cohering holography and the polarization fluctuation compensation can operate on hundreds of fibers in parallel, enabling both coherent optical signal processing with FTDLs and coherent fiber remoting of optically modulated RF signals from antenna arrays.     

Pathophysiological effects of hemodilution in chronic mountain sickness in rats

We examined the effect of isovolemic hemodilution in a rat model of chronic mountain sickness (CMS). After 30 days at simulated high altitude (5,500 m), Hilltop rats had developed evidence of CMS: severe hypoxemia, polycythemia, and pulmonary arterial hypertension. Isovolemic hemodilution to a mean hematocrit of 46 +/- 5% was well tolerated by both the hypoxia-sensitive Hilltop rats and the companion Madison rat strain that does not develop CMS. After hemodilution, we found no evidence of sustained improvements in ventilation or gas exchange in either strain. Despite the fall in blood viscosity, cardiac output increased only marginally, and pulmonary arterial hypertension persisted in the Hilltop rats. Vascular hindrance increased after hemodilution, preventing a significant decline in pulmonary and systemic vascular resistances in the Hilltop rats. Blood O2 content and the coefficient of O2 delivery fell after hemodilution, but O2 consumption was sustained at a normal level after hemodilution by increasing the extraction fraction in the Hilltop strain. There was systemic hypotension through the first day of hemodilution, but this was the only apparent adverse effect of hemodilution. We conclude that isovolemic hemodilution was well tolerated despite the reduction in tissue O2 delivery. However, hemodilution failed to improve any of the respiratory and cardiovascular manifestations of CMS in Hilltop rats.