Evaluation of the mechanical behavior of W7-X central support connections by means of semi-automated FE analysis

The stellarator Wendelstein 7-X is under construction at the Max-Planck-Institut für Plasmaphysik in Greifswald. Its superconducting coil system is fixed by a massive structure. During machine operation the coils exert high forces and moments against each other and the central support structure (CSS). Therefore, the detailed analysis of the coil to CSS connections, the so-called central support elements (CSE), is a critical item. The major details of the design have been frozen; nevertheless, there is still need for detailed analysis of the CSEs due to assembly issues, and later on for exploring operational limits of the machine. These analyses have to be performed quickly, reliably, and shall provide results in a standardized form to enable timely responses to the assembly team. Special numerical tools – finite element (FE) parametric models of CSEs – have been developed for the purpose of such analyses. In the models, the geometry, material properties, contact conditions, loads as well as results presentation are defined in a parametric way. The use of the developed models for the definition of the final weld parameters, bolt preloads, assessment of acceptable tolerances, and optimal positions of the CSE-wedges before welding is also discussed.     

Structural analysis of W7-X: From design to assembly and operation

The Wendelstein 7-X (W7-X) modular stellarator is in the assembly phase at the Max-Planck-Institut für Plasmaphysik in Greifswald, Germany. The design of the “basic machine”, i.e. without in-vessel components, diagnostics and periphery, is largely completed, structural parameters such as bolt preload, initial conditions for contact elements, etc. are defined, and most of the components are manufactured and partly assembled. Therefore, the focus of structural analysis was shifted towards fast analyses of non-conformities, changes in the assembly procedure, and exploration of operational limits. Assembly-related work is expected to continue until commissioning of the machine, however, with decreasing intensity. In parallel the analysis requirements for in-vessel components, diagnostics and periphery will increase.This paper focuses on the most remarkable results, on special problems which had to be solved, on strategic issues like parameterization, complex finite element model structuring and benchmarking with alternative models in different codes, on assumptions of reasonable safety margins and expected tolerances, and on confirmation of analysis results by tests. Finally it highlights some lessons learned so far, which might be relevant also for other large fusion machines, and gives an outlook on future work.     

Infectious diseases in Poland in 1996

Flight activity of insects comprises one of the most intense biochemical processes known in nature, and therefore provides an attractive model system to study the hormonal regulation of metabolism during physical exercise. In long-distance flying insects, such as the migratory locust, both carbohydrate and lipid reserves are utilized as fuels for sustained flight activity. The mobilization of these energy stores in Locusta migratoria is mediated by three structurally related adipokinetic hormones (AKHs), which are all capable of stimulating the release of both carbohydrates and lipids from the fat body. To exert their effects intracellularly, these hormones induce a variety of signal transduction events, involving the activation of AKH receptors, GTP-binding proteins, cyclic AMP, inositol phosphates and Ca2+. In this review, we discuss recent advances in the research into AKH signaling. This not only includes the effects of the three AKHs on each of the signaling molecules, but also crosstalk between signaling cascades and the degradation rates of the hormones in the hemolymph. On the basis of the observed differences between the three AKHs, we have tried to construct a physiological model for their action in locusts, in order to answer a fundamental question in endocrinology: why do several structurally and functionally related peptide hormones co-exist in locusts (and animals in general), when apparently one single hormone would be sufficient to exert the desired effects? We suggest that the success of the migratory locust in performing long-distance flights is in part based on this neuropeptide multiplicity, with AKH-I being the strongest lipid-mobilizing hormone, AKH-II the most powerful carbohydrate mobilizer and AKH-III, a modulatory entity that predominantly serves to provide the animal with energy at rest.     

A new phase-controlled parallel resonant converter

A phase-controlled resonant converter was obtained by connecting in parallel the AC loads of two identical parallel resonant inverters. A phase shift between the drive signals of the two inverters controls the amplitude of the output voltage of the new inverter. A voltage-driven rectifier is used as an AC load of the inverter, which results in a phase-controlled parallel resonant DC-DC converter. A frequency-domain analysis is performed for the steady-state operation of the inverter, and two types of voltage-driven rectifiers and design equations are derived. The converter can be operated at a constant switching frequency, which reduces EMI problems. It is found that for switching frequencies higher than the resonant frequency by a factor of 1.07, the load of each switching leg is inductive. The converter is capable of regulating the output voltage in the range of load resistance from full-load to no-load. Experimental results are presented for a prototype of the phase-controlled parallel resonant converter with a center-taped rectifier tested at an output power of 50 W and a switching frequency of 116 kHz     

Modeling and Digital Control of a Phase-Controlled Series–Parallel Resonant Converter

A nonlinear model for a phase-controlled series-parallel resonant converter is developed using the extended describing function method and d-q decomposition. The model is linearized and reduced using the balanced model reduction technique. Based on the reduced model and taking into account the zero-order hold delay and the computation delay in the sampled-data system, a digital controller for the converter is designed. The controller is implemented with a digital signal processor (DSP). The closed-loop converter with the DSP controller is built and tested experimentally. Recorded transient waveforms show that the closed-loop converter is capable of not only responding to the reference input change as required by the design specifications, but also stabilizing the output effectively under disturbances from both the output and the input     

Scarlet fever in 1996]

A sample population of Rio de Janeiro, Brazil, was tested for D6S132, D7S467, and D17S26 VNTR loci to determine the fixed-bin frequencies of alleles. RFLP analysis was obtained by HaeIII-digested genomic DNA. The three VNTR loci meet Hardy-Weinberg expectations, and there is no evidence for association of alleles between the VNTR loci. The frequency data can be used in forensic analysis, in paternity tests and to estimate the frequency of a DNA profile in the general Brazilian population.     

Multilevel selective harmonic elimination PWM technique inseries-connected voltage inverters

Selective harmonic elimination pulsewidth modulation (SHEPWM) method is systematically applied for the first time to multilevel series-connected voltage-source PWM inverters. The method is implemented based on optimization techniques. The optimization starting point is obtained using a phase-shift harmonic suppression approach. Another less computationally demanding harmonic suppression technique, called a mirror surplus harmonic method, is proposed for double-cell (five-level) inverters. Theoretical results of both methods are verified by experiments and simulations for a double-cell inverter. Simulation results for a five-cell (11-level) inverter are also presented for the multilevel SHEPWM method     

Robust stability of state-feedback control of PWM DC-DC push-pullconverter

A state-feedback control strategy was recently used to design a pulse-width modulated (PWM) power converter which accommodates disturbances as long as the system remains stable. A robust stability analysis of the closed-loop PWM push-pull DC-DC power converter with a state feedback is presented by using the Kharitonov theorem     

The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome

Insulin resistance is documented in clamp studies in 75% of women with polycystic ovary syndrome (PCOS). Although it is not included in the diagnostic criteria of PCOS, there is a crucial role of this metabolic impairment, which along with hormonal abnormalities, increase each other in a vicious circle of PCOS pathogenesis. Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species. While lifestyle intervention has a first-line role in the prevention and management of excess weight in PCOS, the role of anti-obesity pharmacological agents in achieving and maintaining weight loss is being increasingly recognized. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) not only act by reducing body weight but also can affect the mechanisms involved in insulin resistance, like an increasing expression of glucose transporters in insulin-dependent tissues, decreasing inflammation, reducing oxidative stress, and modulating lipid metabolism. They also tend to improve fertility either by increasing LH surge in hypothalamus-pituitary inhibition due to estrogen excess connected with obesity or decreasing too high LH levels accompanying hyperinsulinemia. GLP1-RAs seem promising for effective treatment of obese PCOS patients, acting on one of the primary causes of PCOS at the molecular level.