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1.
Ji Hye Yang Sae Kwang Ku IL Je Cho Je Hyeon Lee Chang-Su Na Sung Hwan Ki 《International journal of molecular sciences》2021,22(4)
Hepatic fibrosis occurs when liver tissue becomes scarred from repetitive liver injury and inflammatory responses; it can progress to cirrhosis and eventually to hepatocellular carcinoma. Previously, we reported that neoagarooligosaccharides (NAOs), produced by the hydrolysis of agar by β-agarases, have hepatoprotective effects against acetaminophen overdose-induced acute liver injury. However, the effect of NAOs on chronic liver injury, including hepatic fibrosis, has not yet been elucidated. Therefore, we examined whether NAOs protect against fibrogenesis in vitro and in vivo. NAOs ameliorated PAI-1, α-SMA, CTGF and fibronectin protein expression and decreased mRNA levels of fibrogenic genes in TGF-β-treated LX-2 cells. Furthermore, downstream of TGF-β, the Smad signaling pathway was inhibited by NAOs in LX-2 cells. Treatment with NAOs diminished the severity of hepatic injury, as evidenced by reduction in serum alanine aminotransferase and aspartate aminotransferase levels, in carbon tetrachloride (CCl4)-induced liver fibrosis mouse models. Moreover, NAOs markedly blocked histopathological changes and collagen accumulation, as shown by H&E and Sirius red staining, respectively. Finally, NAOs antagonized the CCl4-induced upregulation of the protein and mRNA levels of fibrogenic genes in the liver. In conclusion, our findings suggest that NAOs may be a promising candidate for the prevention and treatment of chronic liver injury via inhibition of the TGF-β/Smad signaling pathway. 相似文献
2.
Hong Sae Jin Park Nam Il Hwang Dae Keun Yi Tae Gyu Eum Hyang Lan 《Food science and biotechnology》2022,31(6):669-679
Food Science and Biotechnology - Various hilling materials (rice hulls, pine sawdust, and perlite) were compared to produce sprout vegetables using beach silvertop (Glehnia littoralis Fr. Schm. ex... 相似文献
3.
目的:设计一款满足安全、卫生、操作便捷、结构性能稳定等要求的糖霜制品3D打印机.方法:打印机主要包括机械结构和控制系统,机械结构方面采用龙门架结构,并对传统的打印料罐进行改良.控制系统采用“工控机+运动控制卡”的模式.结果:该打印机可快速更换料罐(30s内),打印机成型速度快(≥5000mm/min),速度可调;成型精度控制在1mm 以内;成型件的强度、膨胀率和表面粗糙度指标均较好.自带光源的图像识别及处理系统能够识别产品形状、个数及完整性等.结论:改良后的料罐提高了半流体食品打印的卫生性、生产效率,且便于耗材的更换,能加工出复杂糖画模型以满足造型独特的个性化糖艺制品的需求. 相似文献
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5.
Tongling Xia Yue Qi Xilei Dai Jinyu Liu Can Xiao Ruoyu You Dayi Lai Junjie Liu Chun Chen 《Indoor air》2021,31(6):2020-2032
To evaluate the separate impacts on human health and establish effective control strategies, it is crucial to estimate the contribution of outdoor infiltration and indoor emission to indoor PM2.5 in buildings. This study used an algorithm to automatically estimate the long-term time-resolved indoor PM2.5 of outdoor and indoor origin in real apartments with natural ventilation. The inputs for the algorithm were only the time-resolved indoor/outdoor PM2.5 concentrations and occupants’ window actions, which were easily obtained from the low-cost sensors. This study first applied the algorithm in an apartment in Tianjin, China. The indoor/outdoor contribution to the gross indoor exposure and time-resolved infiltration factor were automatically estimated using the algorithm. The influence of outdoor PM2.5 data source and algorithm parameters on the estimated results was analyzed. The algorithm was then applied in four other apartments located in Chongqing, Shenyang, Xi'an, and Urumqi to further demonstrate its feasibility. The results provided indirect evidence, such as the plausible explanations for seasonal and spatial variation, to partially support the success of the algorithm used in real apartments. Through the analysis, this study also identified several further development directions to facilitate the practical applications of the algorithm, such as robust long-term outdoor PM2.5 monitoring using low-cost light-scattering sensors. 相似文献
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8.
Fangjun Zhu You Shi Guorong Hu Zhongdong Peng Yanbing Cao Qian Sun Zhichen Xue Yinjia Zhang Ke Du 《Ceramics International》2021,47(3):3070-3078
Titanium and boron are simultaneously introduced into LiNi0.8Co0.1Mn0.1O2 to improve the structural stability and electrochemical performance of the material. X-ray diffraction studies reveal that Ti4+ ion replaces Li+ ion and reduces the cation mixing; B3+ ion enters the tetrahedron of the transition metal layers and enlarges the distance of the [LiO6] layers. The co-doped sample has spherical secondary particles with elongated and enlarged primary particles, in which Ti and B elements distribute uniformly. Electrochemical studies reveal the co-doped sample has improved rate performance (183.1 mAh·g-1 at 1 C and 155.5 mAh·g-1 at 10 C) and cycle stability (capacity retention of 94.7% after 100 cycles at 1 C). EIS and CV disclose that Ti and B co-doping reduces charge transfer impedance and suppresses phase change of LiNi0.8Co0.1Mn0.1O2. 相似文献
9.
Young Been Kim Sung Hyeon Jung Dong Su Kim Nishad G. Deshpande Hee Won Suh Hak Hyeon Lee Ji Hoon Choi Ho Seong Lee Hyung Koun Cho 《Advanced functional materials》2021,31(38):2102439
Antimony triselenide (Sb2Se3) nanoflake-based nitrogen dioxide (NO2) sensors exhibit a progressive bifunctional gas-sensing performance, with a rapid alarm for hazardous highly concentrated gases, and an advanced memory-type function for low-concentration (<1 ppm) monitoring repeated under potentially fatal exposure. Rectangular and cuboid shaped Sb2Se3 nanoflakes, comprising van der Waals planes with large surface areas and covalent bond planes with small areas, can rapidly detect a wide range of NO2 gas concentrations from 0.1 to 100 ppm. These Sb2Se3 nanoflakes are found to be suitable for physisorption-based gas sensing owing to their anisotropic quasi-2D crystal structure with extremely enlarged van der Waals planes, where they are humidity-insensitive and consequently exhibit an extremely stable baseline current. The Sb2Se3 nanoflake sensor exhibits a room-temperature/low-voltage operation, which is noticeable owing to its low energy consumption and rapid response even under a NO2 gas flow of only 1 ppm. As a result, the Sb2Se3 nanoflake sensor is suitable for the development of a rapid alarm system. Furthermore, the persistent gas-sensing conductivity of the sensor with a slow decaying current can enable the development of a progressive memory-type sensor that retains the previous signal under irregular gas injection at low concentrations. 相似文献
10.
铁煤集团大兴矿(以下简称"大兴矿")2019年产240万t,井田位于铁法煤田的西南角,火成岩侵入及地质构造复杂,煤层破坏程度严重[1-2]。受火成岩影响,煤层瓦斯含量大幅增加[3-4],渗透性能差,力学强度低,煤的含水率低,自然发火期较短,是煤与瓦斯突出矿井。在采煤过程中,防治自然发火是重中之重,综采设备在设计初期未考虑实施灭火的操作空间,为此,笔者提出通过改造综采设备增加实施灭火的操作空间,降低出现自然发火灾害时防治的难度,保证采煤安全。 相似文献