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排序方式: 共有1080条查询结果,搜索用时 15 毫秒
1.
David Diaz Elisa Lopez-Dolado Sergio Haro Jorge Monserrat Carlos Martinez-Alonso Dimitrios Balomeros Agustín Albillos Melchor Alvarez-Mon 《International journal of molecular sciences》2021,22(2)
Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14+highCD16−, CD14+highCD16+, and CD14+lowCD16+ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14+highCD16− and CD14+highCD16+ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14+highCD16− monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage. 相似文献
2.
Konstantinos Spyrou Matteo Calvaresi Evmorfia K. Diamanti Theodoros Tsoufis Dimitrios Gournis Petra Rudolf Francesco Zerbetto 《Advanced functional materials》2015,25(2):263-269
Experimental and theoretical studies are performed in order to illuminate, for first time, the intercalation mechanism of polycyclic aromatic molecules into graphite oxide. Two representative molecules of this family, aniline and naphthalene amine are investigated. After intercalation, aniline molecules prefer to covalently connect to the graphene oxide matrix via chemical grafting, while napthalene amine molecules bind with the graphene oxide surface through π–π interactions. The presence of intercalated aromatic molecules between the graphene oxide layers is demonstrated by X‐ray diffraction, while the type of interaction between graphene oxide and polycyclic organic molecules is elucidated by X‐ray photoelectron spectroscopy. Combined quantum mechanical and molecular mechanical calculations describe the intercalation mechanism and the aniline grafting, rationalizing the experimental data. The present work opens new perspectives for the interaction of various aromatic molecules with graphite oxide and the so‐called “intercalation chemistry”. 相似文献
3.
Samples removed from funeral figurines, dated the third to the second century BC (Hellenistic period) and found in Macedonia, Greece, are investigated using high‐performance liquid chromatography. Two results are reported that provide new insights into ancient polychromy. Firstly, high‐performance liquid chromatography results, in combination with historical information, indicate that insect species of cochineal, most probably Porphyrophora hamelii Brandt, was used in Hellenistic objects. Secondly, madder detected in the archaeological samples contains high amounts of purpurin (alizarin is either not detected or detected in trace). This relative composition, which is recorded using the hydrochloric acid method for dyestuff extraction, is consistent with that prepared from wild madder (Rubia peregrina L.), which is a common plant in the Mediterranean region. 相似文献
4.
5.
Multifilament Ag-sheathed BiPbSrCaCuO (2223) superconducting tapes containing 49 filaments were fabricated by the powder-in-tube route and the roll-anneal process. The transport critical current densityJ
c
was 1.3×104 A cm–2 at 77 K and 7×104 A cm–2 at 4.2 K in self-field. A 12-m-long tape was used to construct superconducting solenoids (50, 28, and 14 mm internal diameters) generating dc fields 380–1070 G at 4.2 K. Measurements of the variation ofJ
c
with field (0–1.6 T) and bend strain (0–5%) are used to explain the performance of the solenoids. The critical bend strain of tapes was about 1.5%. 相似文献
6.
Dimitrios Tzovaras Nikos Grammalidis Michael G. Strintzis 《Signal Processing: Image Communication》1998,11(3):205-230
In the present paper techniques are examined for the coding of the depth map and disparity fields for stereo or multiview image communication applications. It is assumed that both the left and right channels of the multiview image sequence are coded using block- or object-based methods. A dynamic programming algorithm is used to estimate a disparity field between each stereo image pair. Depth is then estimated and occlusions are optionally detected, based on the estimated disparity fields. Spatial interpolation techniques are examined based on the disparity/depth information and the detection of occluded regions using either stereoscopic or trinocular camera configurations. It is seen that the presence of a third camera at the transmitter site improves the estimation of disparities, the detection of occlusions and the accuracy of the resulting spatial interpolation at the receiver. Various disparity field and depth map coding techniques are then proposed and evaluated, with emphasis given to the quality of the resulting intermediate images at the receiver site. Block-based and wireframe modeling techniques are examined for the coding of isolated depth or disparity map information. Further, 2D and 3D motion compensation techniques are evaluated for the coding of sequences of depth or disparity maps. The motion fields needed may be available as a byproduct of block-based or object-based coding of the intensity images. Experimental results are given for the evaluation of the performance of the proposed coding and spatial interpolation methods. 相似文献
7.
Modeling video sources for real-time scheduling 总被引:1,自引:0,他引:1
What is the impact of the autocorrelation of variable-bit-rate (VBR) sources on real-time scheduling algorithms? Our results show that the impact of long term, or interframe, autocorrelation is negligible, while the impact of short term, or intraframe, autocorrelation can be significant. Such results are essentially independent of the video coding scheme employed. To derive these results, video sequences are modeled as a collection of stationary subsequences called scenes. Within a scene, a statistical model is derived for both the sequence of frames and of slices. The model captures the distribution and the autocorrelation function of real-time video data. In previous work, the pseudoperiodicity of the slice level auto-correlation function made it difficult to develop a simple yet accurate model. We present a generalization of previous methods that can easily capture this pseudoperiodicity and is suited for modeling a greater variety of autocorrelation functions. By simply tuning a few parameters, the model reproduces the statistic behavior of sources with different types and levels of correlation on both the frame and the slice level. 相似文献
8.
What is the value of a scientist and its impact upon the scientific thinking? How can we measure the prestige of a journal or a conference? The evaluation of the scientific work of a scientist and the estimation of the quality of a journal or conference has long attracted significant interest, due to the benefits by obtaining an unbiased and fair criterion. Although it appears to be simple, defining a quality metric is not an easy task. To overcome the disadvantages of the present metrics used for ranking scientists and journals, J. E. Hirsch proposed a pioneering metric, the now famous h-index. In this article we demonstrate several inefficiencies of this index and develop a pair of generalizations and effective variants of it to deal with scientist ranking and publication forum ranking. The new citation indices are able to disclose trendsetters in scientific research, as well as researchers that constantly shape their field with their influential work, no matter how old they are. We exhibit the effectiveness and the benefits of the new indices to unfold the full potential of the h-index, with extensive experimental results obtained from the DBLP, a widely known on-line digital library. 相似文献
9.
Eleni Papakonstantinou Dimitrios Vlachakis Trias Thireou Panayiotis G. Vlachoyiannopoulos Elias Eliopoulos 《International journal of molecular sciences》2021,22(6)
Monocarboxylate transporters (MCTs) are of great research interest for their role in cancer cell metabolism and their potential ability to transport pharmacologically relevant compounds across the membrane. Each member of the MCT family could potentially provide novel therapeutic approaches to various diseases. The major differences among MCTs are related to each of their specific metabolic roles, their relative substrate and inhibitor affinities, the regulation of their expression, their intracellular localization, and their tissue distribution. MCT4 is the main mediator for the efflux of L-lactate produced in the cell. Thus, MCT4 maintains the glycolytic phenotype of the cancer cell by supplying the molecular resources for tumor cell proliferation and promotes the acidification of the extracellular microenvironment from the co-transport of protons. A promising therapeutic strategy in anti-cancer drug design is the selective inhibition of MCT4 for the glycolytic suppression of solid tumors. A small number of studies indicate molecules for dual inhibition of MCT1 and MCT4; however, no selective inhibitor with high-affinity for MCT4 has been identified. In this study, we attempt to approach the structural characteristics of MCT4 through an in silico pipeline for molecular modelling and pharmacophore elucidation towards the identification of specific inhibitors as a novel anti-cancer strategy. 相似文献
10.