敏捷企业（下）

上半部分全面介绍了敏捷企业的有关概念和企业开展敏捷化工程的有关问题。从企业外部到企业内部，对影响企业敏捷性的因素做了比较详细的分析。给出了一个供美国工业界实施敏捷化工物关键因素优优表，并对中国企业如何利用目前的机遇，通过建立全国一致的商务交换标准和技术体系来国际大合作的问题提出了具体的建议。下半部分从国工程的概念出发，着重描述了ＲＲＳ的概念，并通过实例进一步阐述了ＲＲＳ的１０条设计准则。     

Anisotropy-Based Failure Criterion for Interphase Systems

This paper presents a methodology for estimating the shear strength of interphase systems composed of granular materials and planar inclusions having various degrees of roughness. Existing empirical and semiempirical relationships between strength and surface roughness do not appear to be general and are unable to account for surface-particle interactions at the appropriate scales. The proposed method is based on the contact force anisotropy of those particles that touch the inclusion surface. It was developed using two-dimensional discrete element method simulations of interphase systems constructed within a direct interface shear test device. Particles consist of polydisperse and monodisperse spheres of constant median grain diameter. Surface roughness was varied by using profiles with regular and random asperities, and profiles of manufactured surfaces. Results indicate that the magnitude and direction of average contact total force at the interface controls strength. A bilinear relationship, independent of particle to surface friction coefficient, exists between the principal direction of contact total force anisotropy and strength. Results using the proposed criterion are in good agreement with laboratory results using spheres and subrounded sand.     

华硕市场风云变幻为哪般？

华硕A7V断货前途未卜 前些日子华硕A7V主板到货了,不过货量极小,笔者在一家电脑城里转悠了大半天也只发现大约20片(当然它们就是零售版本),所以这批货2天时间就售光了。也就是说,目前已经无法买到A7V了。 我得到的最新情报,华硕很有可能不在大陆市场销售此款主板,这对于我们这些DIY来说,可是一个不幸的消息。当然,目前这还只是一个议案,是否执行还是一个未知数。提出这个议案主要是因为此主板的成本过高,使得它的零售价     

Mechanism-based inactivation of a yeast methylamine oxidase mutant: implications for the functional role of the consensus sequence surrounding topaquinone

The copper-containing yeast methylamine oxidase E406N mutant has an altered consensus sequence surrounding the topaquinone cofactor (residue 405). The mutation has no effect on the final yield of the active-site topaquinone cofactor during biogenesis but causes the enzyme to be inactivated by substrate methylamine [Cai, D., and Klinman, J. P. (1994) Biochemistry 33, 7674-7653]. In this study we show that the inactivation leads to the formation of a covalent adduct, which has a UV/vis spectrum very similar to that of a product Schiff base, an intermediate of topaquinone-catalyzed amine oxidation reactions. The kinetic isotope effects on the second-order rate constant for the inactivation and catalytic turnover are identical, indicating that the two processes share a common intermediate that follows C_H bond cleavage. Resonance Raman spectroscopy provides direct evidence for the accumulation of a neutral product Schiff base species. Removal of excess methylamine leads to recovery of both activity and the native absorption spectrum for E406N, indicating that the cofactor in the inactivated enzyme is chemically competent for hydrolysis. The rate of the reactivation is slow, however; the shortest half-life of the inhibited E406N at 25 degrees C is 5.9 min at pH 6.15. pH effect experiments show that the inactivation and reactivation steps are controlled by a single ionizable group with a pKa of 6.9-7.1; under basic conditions, when this residue is deprotonated, the inactivation is the fastest and the half-life of the inhibited enzyme is the longest. On the basis of the available crystal structures of copper amine oxidases, we propose that a histidine residue in the dimer interface is responsible for the observed ionization. In the wild-type enzyme this histidine is kept protonated by virtue of Glu at position 406. Unlike methylamine, the larger substrates ethylamine and benzylamine give normal turnover with E406N. Disruption of structure at the subunit interface in E406N may allow a rotation of the relatively small topa-product Schiff base complex (formed from methylamine) away from the active-site base to a conformation that is incompetent toward hydrolysis.     

Imidazolylpropylguanidines as histamine H2 receptor agonists:3D-QSAR of a large series

Functional impairment has long been recognized as an important factor in the risk paradigm among patients with heart disease. In chronic heart failure, this issue has been even more important in recent years because of the steady growth in the number of patients awaiting heart transplantation relative to the available pool of donor hearts. The use of gas-exchange techniques to assess patients with heart failure has attracted interest because these techniques provide a more precise, reproducible, objective, and physiologic expression of exercise tolerance. Numerous studies published in the 1990s demonstrate that maximal oxygen uptake (peak VO2) is an independent predictor of mortality in patients with heart failure. Achievement of a peak VO2 that is less than 14 mL/kg/min has been recognized as one of the relative indications for transplantation, because patients who achieve a measurement that is higher than 14 mL/kg/min have a 1-year mortality rate similar to that of patients who undergo transplantation (i.e., > 90%). However, some debate exists regarding the optimal cutpoint that separates survivors from nonsurvivors, and studies have not consistently defined the timing of the test relative to optimization of medical therapy. It has also been debated which hemodynamic variables, at rest or during exercise, should be used in combination with peak VO2 to optimally stratify risk in these patients. This article reviews the applications of cardiopulmonary exercise testing in prognosis among patients with chronic heart failure.     

Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease

Marijuana, Cannabis sativa, elicits a variety of effects in experimental animals and humans. Delta-9-tetrahydrocannabinol (THC) is the major psychoactive component in marijuana. This substance has been shown, also, to be immunosuppressive and to decrease host resistance to bacterial, protozoan, and viral infections. Macrophages, T lymphocytes, and natural killer cells appear to be major targets of the immunosuppressive effects of THC. Definitive data which directly link marijuana use to increased susceptibility to infection in humans currently is unavailable. However, cumulative reports indicating that THC alters resistance to infection in vitro and in a variety of experimental animals support the hypothesis that a similar effect occurs in humans.     

Phase Transitions and Therrnoluminescence of a Plasma-Sprayed Zinc Silicate Phosphor

A plasma-sprayed zinc silicate phosphor was heat-treated at ∼800°C informing gas; the major phase present was the metastable β phase, as revealed by bright yellow fluorescence under uv excitation. On heat treatment at ∼1000°C in air, a green, fluorescence developed as a result of the formation of the stable a phase. However, its thermo luminescence characteristics were different from those of the original P1 phosphor used for spraying     

Oxidation induced bending of metal foils

An explanation is given of the observation that bent metal foils undergo further bending when subjected to oxidation. Experiments carried out on nickel foils show that the effect depends on foil thickness, initial angle of bend, and temperature. The results are in agreement with the predictions of a model based on a conformational misfit generated at the metal-metal oxide interface during oxidation. Formerly an Assistant Professor at the University of Florida