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排序方式: 共有533条查询结果,搜索用时 15 毫秒
1.
NB Haas RJ Schilder S Nash LM Weiner RC Catalano RF Ozols PJ O''Dwyer 《Canadian Metallurgical Quarterly》1995,13(3):229-233
We examined 59 breast cancers for p53 and bcl-2 protein expression by immunohistochemistry. The results were correlated with Ki-67 immunostaining. p53-negativity was noted in 40 cases and the remaining 19 tumours were p53-positive. Thirty-six tumours showed strong expression of bcl-2 and in 23 no staining for this protein was observed. We found statistically significant reverse correlation between expression of p53 and bcl-2 in majority of carcinomas: 31 cases were bcl-2 positive and p53-negative, and 14 tumours were bcl-2-negative and p53-positive. Six carcinomas showed no nuclear staining for Ki-67 and in the remaining 53 the percent of cancer cells positive for Ki-67 ranged from 1 to 60 (mean: 14.6). In these 53 cases we found that bcl-2-positive tumours were characterized by lower proliferation than bcl-2-negative tumours, the mean value of Ki-67 immunostaining being 10.7% and 23.0%, respectively. p53-negative tumours showed lower proliferation than p53-positive tumours: mean Ki-67 index was 10.2% and 23.9%, respectively. We conclude that immunohistochemically detected p53 and bcl-2 proteins show a significant inverse relationship in majority of breast carcinomas and their expression correlates with tumour proliferation (Ki-67 immunostaining). 相似文献
2.
Eamon Nash 《电子与电脑》2007,(7):69-75
问:我才刚阅读完ADI近期所发表的对数放大器相关技术手册,不过我对于对数放大器究竟是什么仍然感到有些困惑. 答:你并不是唯一感到困惑的人.许多年来,我已经处理过许多的询问,都是有关于对数放大器所执行功能的重点差异,以及在本质上完全不同的设计概念.就让我们这样子开始好了,你希望在对数放大器的输出中看到什么? 相似文献
3.
Performance on antisaccade trials requires the inhibition of a prepotent response (i.e., don't look at the flashing cue) and the generation and execution of a correct saccade in the opposite direction. The authors attempted to further specify the role of working memory (WM) span differences in the antisaccade task. They tested high- and low-span individuals on variants of prosaccade and antisaccade trials in which an eye movement is the sole requirement. In 3 experiments, they demonstrated the importance of WM span differences in both suppression of a reflexive saccade and generation of a volitional eye movement. The results support the contention that individual differences in WM span are not exclusively due to differences in inhibition but also reflect differences in directing the focus of attention. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
AR Dluzewski GB Nash RJ Wilson DM Reardon WB Gratzer 《Canadian Metallurgical Quarterly》1992,55(1-2):1-7
Hereditary ovalocytes (stomatocytic ovalocytes), when examined within 1-2 days from the time that the blood sample is drawn, are invaded by Plasmodium falciparum in culture to the extent of at least 55% of normal control cells. The ovalocytes have extremely rigid membranes, characterised by a shear elastic modulus some 3-4 times greater than that of normal cells. The extent of invasion falls off very much more rapidly than that into normal cells on storage, and we surmise that this is the reason for earlier reports of resistance of ovalocytes to malarial invasion in vitro. The initial loss of susceptibility to invasion with time is not accompanied by any change in membrane rigidity, but is primarily a consequence of a rapid decline in intracellular ATP concentration: this falls to below the threshold level required for invasion (approx. 0.1 mM) over a period in which the ATP in normal cells remains almost constant. Incubation in a metabolic regenerating medium leads to a rise in the intracellular ATP concentration and invasion by P. falciparum is recovered, though to a much lower extent than in normal cells. The resistance of ovalocytes to invasion becomes irreversible, due possibly to degradative processes in the membrane, on further storage. The developing parasites in ovalocytes have a reduced number of merozoites and show distinct morphological abnormalities. 相似文献
5.
6.
Several Ni-Al-Mo-based eutectic superalloys were rapidly solidified using a chilled block melt spinning process. The effects of rapid solidification on the microstructure were studied using optical microscopy, transmission electron microscopy (TEM), and scanning transmission electron microscopy (STEM). Results showed, except for the alloy containing chromium, that the microstructure varied as a function of ribbon thickness from segregationless solidification at the wheel side of the ribbon to dendritic solidification at the free side. In addition, alloys with the same solidification rate showed a large variation in microstructure depending upon the solid state cooling rate. The rapidly solidified eutectic Ni-Al-Mo alloy with a small amount of rhenium and vanadium did not show any improvement on delaying or prohibiting the formation of the embrittling-NiMo phase on ageing at 1000 C. This was determined from microstructural as well as chemical analysis using STEM. Differential thermal analysis was used to obtain melting temperature,-Ni3Al solvus, and heat of formation for the alloys. 相似文献
7.
Dr. R. B. Schwarz Ph.D. Dr. P. Nash Ph.D. 《JOM Journal of the Minerals, Metals and Materials Society》1989,41(1):27-31
The recent discovery that amorphous alloy powders can be prepared by mechanically alloying a mixture of pure crystalline intermetallics is opening new windows to the synthesis of engineering materials. Amorphous powders synthesized by mechanical alloying may find application in the design of structural alloys, high thermal conductivity alloys, and metal-matrix composites. 相似文献
8.
The V–Si system is reassessed based on a critical literature review involving recently reported data and the present experimental data. These new data include the thermodynamic stability of V 6Si5 and the enthalpies of formation for the compounds calculated by first-principles method. Two alloys were prepared in the region of (Si)+V Si2 and annealed at 1273 K for 14 days. After X-ray diffraction (XRD) and chemical analysis of these alloys were performed, the eutectic reaction (L⇔(Si)+V Si2) temperature was determined by differential thermal analysis (DTA). Self-consistent thermodynamic parameters for the V–Si system were obtained by optimization of the selected experimental values. The calculated phase diagram and thermodynamic properties agree well with the experimental ones. Noticeable improvements have been made, compared with the previous assessments. 相似文献
9.
Cheng Shi Nathan H. Mahlmeister Isaac J. Luxmoore Geoffrey R. Nash 《Nano Research》2018,11(7):3567-3573
A thermal emitter composed of a frequency-selective surface metamaterial layer and a hexagonal boron nitride-encapsulated graphene filament is demonstrated. The broadband thermal emission of the metamaterial (consisting of ring resonators) was tailored into two discrete bands, and the measured reflection and emission spectra agreed well with the simulation results. The high modulation frequencies that can be obtained in these devices, coupled with their operation in air, confirm their feasibility for use in applications such as gas sensing. 相似文献
10.
Masoud Mohazzab Norbert Mulders Melora Larson Al Nash 《Journal of Low Temperature Physics》1998,113(5-6):1031-1036
In this paper we discuss a pulsed second sound experiment, aimed at determining accurately the critical exponent , and the predicted logarithmic correction to scaling, for the superfluid density along a tricritical path in the
3
He-
4
He phase diagram. We present an accurate estimate for the limits for closest approach to the tricritical point, as set by gravitationally induced sample inhomogeneities and finite size effects, and discuss some of the complications associated with measurements close to the tricritical point. 相似文献