Influence of corticotropin-releasing factor on pancreatic and islet blood flow in different regions of the rat pancreas

Corticotropin-releasing factor (CRF) has previously been shown to selectively dilate the mesenteric vascular bed, without affecting other vascular beds. Pancreatic blood flow and islet blood flow were therefore measured separately with a microsphere technique in the two regions of the rat pancreas perfused by the superior mesenteric artery (SMA) or celiac artery (CA) respectively. Intravenous infusion of CRF (0.25 microgram/kg b.w./min) caused an increase in both whole pancreatic blood flow and islet blood flow in the region of the pancreas perfused by the SMA. The fraction of whole pancreatic blood flow diverted through the islets in this part of the pancreas was, however, unaffected by CRF infusion (approximately 10%). CRF did not change either pancreatic or islet blood flow in the CA-perfused part of the pancreas, and did not affect the release of insulin.     

Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males

The effect of 2 months of treatment with the oral growth hormone (GH) secretagogue MK-677 on markers of bone metabolism was determined in healthy obese male subjects. This was a randomized, double-blind, parallel, placebo-controlled study. Twenty-four healthy obese males, 19-49 years of age, with body mass index > 30 kg/m2 were treated with MK-677 (25 mg/day; n = 12) or placebo (n = 12) for 8 weeks. MK-677 increased markers of bone formation; a 23% increase in the carboxy-terminal propeptide of type I procollagen levels and a 28% increase in procollagen III peptide levels were seen with as little as 2 weeks of MK-677 treatment (p < 0.01 and p = 0.001 vs. placebo, respectively) while a 15% increase in serum levels of osteocalcin was not detected until 8 weeks of treatment (p < 0.01 vs. placebo). Markers of bone resorption were induced within 2 weeks of treatment with MK-677; serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen were increased 26% at 8 weeks (p = 0.001 vs. placebo), and urine hydroxyproline/creatinine and calcium/creatinine ratios at 8 weeks were increased by 23% (p < 0.05 vs. placebo) and 46% (p < 0.05 vs placebo), respectively, MK-677 increased serum insulin-like growth factor binding protein-5 (IGFBP-5) by 43-44% after 2-8 weeks of treatment (p < 0.01 vs. placebo). Serum IGFBP-4 was increased by 25% after 2 weeks of treatment (p < 0.001 vs. placebo) but no significant change from baseline was observed after 8 weeks of treatment. Plasma interleukin-6 was not significantly changed by active treatment. In conclusion, short-term treatment of healthy obese male volunteers with the GH secretagogue MK-677 increases markers of both bone resorption and formation. Large increases in serum levels of IGF-1 and IGFBP-5 and a transient increase in serum IGFBP-4 were found. Future long-term studies are needed to investigate if prolonged treatment with MK-677 increases bone mass.     

An anomaly in the necking behavior of polyethylene

Tensile creep measurements at constant load on nonoriented polyethylene have shown a marked transition at a certain stress level from a neck formation followed by instantaneous fracture to the formation of a neck which resists fracture for a considerable time. The transition, which shifts towards shorter time and higher nominal stress with increasing molecular weight, has been studied for 16 polyethylenes of different molecular weights, degrees of branching and crystalline structures. The marked. transition has only been observed for high density polyethylene of high molecular weight. Deformation measurements show a more distinct necking for the high density than for the medium density polyethylenes. This is consistent with current molecular deformation theories. A hypothesis for the transition is proposed based on the distinctness of the neck process in the high density polyethylene and the large difference in strength between the spherulitic structure and the fibrillar structure. The dependence of the transition on molecular weight is expected since the number of tic chains incrcrtses with increasing molecular weight.     

A dual-affinity gene fusion system to express small recombinant proteins in a soluble form: expression and characterization of protein A deletion mutants

A novel gene fusion system to express and purify small recombinantproteins in Escherichia coli has been constructed. The conceptallows for affinity purification of soluble gene products bysequential albumin- and Zn²+-affinity chromatography. The dual-affinitysystem is well suited for expression of unstable proteins asonly full-length protein is obtained after purification andproteins gain proteolytic stability in the fusion protein. Herewe show that the dual-affinity approach can be used for theexpression of various unstable derivatives of a single IgG-bindingdomain based on staphylococcal protein A. Analysis of the proteolyticstabilities and the IgG-binding properties of the differentmutant proteins suggest that the model for the structure ofan IgG-binding domain must be re-evaluated.     

‘Podracing’: experimenting with mobile TV content consumption and delivery methods

Recently, mobile TV has been launched in several countries. While mobile TV integrates television contents into mobile phones, the most personal of communication devices, it becomes interesting to know how this feature will be used throughout the day and in varying contexts of everyday life. This paper presents empirical results on the use of mobile TV with different delivery mechanisms and both quantitative and qualitative results on how end-users prefer to use mobile TV contents in different situations. The data is based on ongoing empirical research in Finland in 2006 and 2007. The mobile TV services under study included both news and entertainment contents, and were tested in 3G, DVB-H and Wi-Fi networks using different delivery paradigms: broadcast, on-demand and download. To explore the use of different delivery methods and content consumption, we have developed a mobile TV service protoype, called Podracing. The analysis shows that users appreciated up-to-date information and information-rich media forms and contents especially for mobile news delivery. There was high demand for only the latest news on mobiles. The real-time property was considered important. Most of the users looked at the headlines or followed the news several times a day – much more often than the traditional TV and news prime times would allow.     

Quasi three-dimensional, n-bit optical memory based on the ellipsometric principle: model calculations

Model calculations on the ellipsometric memory are presented. The ellipsometric memory is an n-bit optical memory whose information is extracted by use of the ellipsometric principle. The memory cells of the device consist of thin-film multilayer structures, and the information of each memory cell is contained in the optical properties of the thin films. Several thin-film multilayer structures were examined in order to find out how different choices of layer materials and other system parameters such as layer thicknesses and wavelength affect resolutions and limitations of the ellipsometric memory. Such calculations are also useful for optimizing the readout resolution. It was found that it is possible to use memory cells having up to at least eight layers, which would permit 8-bit words to be stored at each location. It was also found that, in principle, several types of materials can be used as layer materials, and various aspects of different choices of materials are discussed.     

Multi-objective Swarm Intelligence schedulers for online scientific Clouds

Cloud Computing is a promising paradigm for parallel computing. However, as Cloud-based services become more dynamic, resource provisioning in Clouds becomes more challenging. The paradigm, with its promise of virtually infinite resources, seems to suit well in solving resource greedy scientific computing problems. In a Cloud, an appropriate number of Virtual Machines (VM) is created and allocated in physical resources for executing jobs. This work focuses on the Infrastructure as a Service (IaaS) model where custom VMs are launched in appropriate hosts available in a Cloud to execute scientific experiments coming from multiple users. Finding optimal solutions to allocate VMs to physical resources is an NP-complete problem, and therefore many heuristics have been developed. In this work, we describe and evaluate two Cloud schedulers based on Swarm Intelligence (SI) techniques, particularly Ant Colony Optimization (ACO) and Particle Swarm Optimization (PSO). The main performance metrics to study are the number of serviced users by the Cloud and the total number of created VMs in online (non-batch) scheduling scenarios. We also perform a sensitivity analysis by varying the specific-parameter values of each algorithm to evaluate the impact on the performance of the two objective metrics. The intra-Cloud network traffic is also measured. Simulated experiments performed using CloudSim and job data from real scientific problems show that the use of SI-based techniques succeeds in balancing the studied metrics compared to Genetic Algorithms.     

Artificial Agent Action in Markets

We summarise our experiences of a number of demonstrators and simulation experiments designed to test the feasibility of using artificial decision making agents in real-time domains, and comment on the significance of our results to autonomous artificial agent action patterns in markets. Our main hypothesis is that the use of norms can extend the capability of artificial decision makers beyond what is obtained from implementing individual utility maximizers in keeping with rational choice theory.     

Liquid-crystalline behaviour of some carboxylic acids

Summary A series of 4--carboxyalkoxyphenyl-4-methoxybenzoates 2 has been prepared. Compounds with a spacer length of n=3 and n=5 show liquid crystalline behaviour. The products were characterized by IR and ¹HNMR-spectroscopy, mass spectrometry, optical microscopy and DSC-measurements. The compounds are potentially useful as side-groups in liquid-crystalline polymers.