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排序方式: 共有529条查询结果,搜索用时 31 毫秒
1.
B Brismar JE Akerlund S Sj?stedt C Johansson A T?rnqvist B B?ckstrand H B?ng L And?ker PO Gustafsson N Darle M Anger?s A Falk G Tunevall B Kasholm-Tengve T Skau PO Nystr?m T Gasslander A Hagelb?ck B Olsson-Liljequist AE Eklund CE Nord 《Canadian Metallurgical Quarterly》1996,28(5):507-512
The objective of this study is to describe usual medical management and costs associated with recurrent respiratory infections in subjects with chronic obstructive bronchitis in France. A prospective survey was performed in Autumn 1994 on a national sample of private practice pulmonologists (N = 71). Two hundred forty-four patients, presenting at least one infection of the lower respiratory tract, were included. Bronchitis was the most frequent acute exacerbation observed (94%). Pneumonia concerned 9% of the patients. Biological tests, X-rays and pulmonary function tests were prescribed for, respectively, 59, 65 and 45% of the patients. Following the visit, 15 patients were hospitalized (6%). The direct medical cost per acute exacerbation was estimated 3,289 francs (1994 value) of which 60% were hospital-related. An average 10.4 day sick-leave was prescribed to 21% of patients in employment. For those patients, this sick-leave was associated to an extra-cost of 1,264-1,876 francs for Social Security and of 0-2,553 francs out of pocket per episode varying according to their Benefit Regimen. 相似文献
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3.
We have made reasonably comprehensive measurements of action potential activity in the Aplysia californica abdominal ganglion to determine the amount of feedback the central nervous system (CNS) receives from a movement which it initiates. Voltage-sensitive dye measurements of action potential activity of cells in the ganglion were made during the gill-withdrawal reflex elicited by siphon stimulation. We compared recordings in two situations which differed dramatically in the amount the gill moved. In the control sea water, the gill withdrawal was normal; in low-Ca2+, high-Mg2+ sea water, the gill movement was blocked. Both the timing and the number of spikes of the individual neurons were similar in the two situations. Histograms of the summed spike activity versus time and histograms of the number of active neurons versus time in the two conditions were also similar. Finally, two numerical measures of trial-to-trial differences, a paired t-test and a measure we named fractional similarity, did not indicate larger differences between two trials in the different sea waters than two trials in the same sea water. Feedback from sensory neurons activated by the gill movement itself does not make a large contribution to the spike activity in the abdominal ganglion. Apparently the Aplysia CNS issues the command for the withdrawal and does not make adjustments for the magnitude of the actual withdrawal. It may not even receive the information necessary for such adjustments to be made. A second motivation for these experiments was to test whether removing the feedback might simplify the neuronal activity that occurs during the gill-withdrawal reflex. This did not occur. 相似文献
4.
Marie Burns Lennard Ostendorf Robert Biesen Andreas Grützkau Falk Hiepe Henrik E. Mei Tobias Alexander 《International journal of molecular sciences》2021,22(5)
Given its uniformly high expression on plasma cells, CD38 has been considered as a therapeutic target in patients with systemic lupus erythematosus (SLE). Herein, we investigate the distribution of CD38 expression by peripheral blood leukocyte lineages to evaluate the potential therapeutic effect of CD38-targeting antibodies on these immune cell subsets and to delineate the use of CD38 as a biomarker in SLE. We analyzed the expression of CD38 on peripheral blood leukocyte subsets by flow and mass cytometry in two different cohorts, comprising a total of 56 SLE patients. The CD38 expression levels were subsequently correlated across immune cell lineages and subsets, and with clinical and serologic disease parameters of SLE. Compared to healthy controls (HC), CD38 expression levels in SLE were significantly increased on circulating plasmacytoid dendritic cells, CD14++CD16+ monocytes, CD56+ CD16dim natural killer cells, marginal zone-like IgD+CD27+ B cells, and on CD4+ and CD8+ memory T cells. Correlation analyses revealed coordinated CD38 expression between individual innate and memory T cell subsets in SLE but not HC. However, CD38 expression levels were heterogeneous across patients, and no correlation was found between CD38 expression on immune cell subsets and the disease activity index SLEDAI-2K or established serologic and immunological markers of disease activity. In conclusion, we identified widespread changes in CD38 expression on SLE immune cells that highly correlated over different leukocyte subsets within individual patients, but was heterogenous within the population of SLE patients, regardless of disease severity or clinical manifestations. As anti-CD38 treatment is being investigated in SLE, our results may have important implications for the personalized targeting of pathogenic leukocytes by anti-CD38 monoclonal antibodies. 相似文献
5.
Michael Hausmann Martin Falk Charlotte Neitzel Andreas Hofmann Abin Biswas Theresa Gier Iva Falkova Dieter W. Heermann Georg Hildenbrand 《International journal of molecular sciences》2021,22(7)
In cancer therapy, the application of (fractionated) harsh radiation treatment is state of the art for many types of tumors. However, ionizing radiation is a “double-edged sword”—it can kill the tumor but can also promote the selection of radioresistant tumor cell clones or even initiate carcinogenesis in the normal irradiated tissue. Individualized radiotherapy would reduce these risks and boost the treatment, but its development requires a deep understanding of DNA damage and repair processes and the corresponding control mechanisms. DNA double strand breaks (DSBs) and their repair play a critical role in the cellular response to radiation. In previous years, it has become apparent that, beyond genetic and epigenetic determinants, the structural aspects of damaged chromatin (i.e., not only of DSBs themselves but also of the whole damage-surrounding chromatin domains) form another layer of complex DSB regulation. In the present article, we summarize the application of super-resolution single molecule localization microscopy (SMLM) for investigations of these structural aspects with emphasis on the relationship between the nano-architecture of radiation-induced repair foci (IRIFs), represented here by γH2AX foci, and their chromatin environment. Using irradiated HeLa cell cultures as an example, we show repair-dependent rearrangements of damaged chromatin and analyze the architecture of γH2AX repair clusters according to topological similarities. Although HeLa cells are known to have highly aberrant genomes, the topological similarity of γH2AX was high, indicating a functional, presumptively genome type-independent relevance of structural aspects in DSB repair. Remarkably, nano-scaled chromatin rearrangements during repair depended both on the chromatin domain type and the treatment. Based on these results, we demonstrate how the nano-architecture and topology of IRIFs and chromatin can be determined, point to the methodological relevance of SMLM, and discuss the consequences of the observed phenomena for the DSB repair network regulation or, for instance, radiation treatment outcomes. 相似文献
6.
Anders?Falk?VikbjergEmail author Lifeng?Peng Huiling?Mu Xuebing?Xu 《Journal of the American Oil Chemists' Society》2005,82(4):237-242
The possibilities of producing structured phospholipids between soybean phospholipids and caprylic acid by lipase-catalyzed
acidolysis were examined in continuous packedbed enzyme reactors. Acidolysis reactions were performed in both a solvent system
and a solvent-free system with the commercially immobilized lipase from Thermomyces lanuginosa (Lipozyme TL IM) as catalyst. In the packed bed reactors, different parameters for the lipase-catalyzed acidolysis were elucidated,
such as solvent ratio (solvent system), temperature, substrate ratio, residence time, water content, and operation stability.
The water content was observed to be very crucial for the acidolysis reaction in packed bed reactors. If no water was added
to the substrate during reactions under the solvent-free system, very low incorporation corporation of caprylic acid was observed.
In both solvent and solvent-free systems, acyl incorporation was favored by a high substrate ratio between acyl donor and
phospholipids, a longer residence time, and a higher reaction temperature. Under certain conditions, the incorporation of
around 30% caprylic acid can be obtained in continuous operation with hexane as the solvent.
Presented at the 95th American Oil Chemists' Society Annual Meeting and Expo in Cincinnati, Ohio, May 10, 2004. 相似文献
7.
In Natural Language Processing, verb classifications have been shown to be useful both theoretically (to capture syntactic and semantic generalisations about verbs) and practically (to support factorisation and the supervised learning of shallow semantic parsers). Acquiring such classifications manually is both costly and errror prone however. In this paper, we present a novel approach for automatically acquiring verb classifications. The approach uses FCA to build a concept lattice from existing linguistic resources; and stability and separation indices to extract from this lattice those concepts that most closely capture verb classes. The approach is evaluated on an established benchmark and shown to differ from previous approaches and in particular, from clustering approaches, in two main ways. First, it supports polysemy (because a verb may belong to several classes). Second, it naturally provides a syntactic and semantic characterisation of the verb classes produced (by creating concepts which systematically associate verbs with their syntactic and semantic attributes). 相似文献
8.
Falk Hüffner Christian Komusiewicz Hannes Moser Rolf Niedermeier 《Theory of Computing Systems》2010,47(1):196-217
We initiate the first systematic study of the NP-hard Cluster Vertex Deletion (CVD) problem (unweighted and weighted) in terms of fixed-parameter algorithmics. In the unweighted case, one searches for a minimum
number of vertex deletions to transform a graph into a collection of disjoint cliques. The parameter is the number of vertex
deletions. We present efficient fixed-parameter algorithms for CVD applying the fairly new iterative compression technique.
Moreover, we study the variant of CVD where the maximum number of cliques to be generated is prespecified. Here, we exploit
connections to fixed-parameter algorithms for (weighted) Vertex Cover. 相似文献
9.
Falk T.H. Wai-Yip Chan 《IEEE transactions on audio, speech, and language processing》2010,18(1):90-100
In this paper, auditory inspired modulation spectral features are used to improve automatic speaker identification (ASI) performance in the presence of room reverberation. The modulation spectral signal representation is obtained by first filtering the speech signal with a 23-channel gammatone filterbank. An eight-channel modulation filterbank is then applied to the temporal envelope of each gammatone filter output. Features are extracted from modulation frequency bands ranging from 3-15 H z and are shown to be robust to mismatch between training and testing conditions and to increasing reverberation levels. To demonstrate the gains obtained with the proposed features, experiments are performed with clean speech, artificially generated reverberant speech, and reverberant speech recorded in a meeting room. Simulation results show that a Gaussian mixture model based ASI system, trained on the proposed features, consistently outperforms a baseline system trained on mel-frequency cepstral coefficients. For multimicrophone ASI applications, three multichannel score combination and adaptive channel selection techniques are investigated and shown to further improve ASI performance. 相似文献
10.
Sofia Cassel Falk Howar Bengt Jonsson Bernhard Steffen 《Formal Aspects of Computing》2016,28(2):233-263
We present a black-box active learning algorithm for inferring extended finite state machines (EFSM)s by dynamic black-box analysis. EFSMs can be used to model both data flow and control behavior of software and hardware components. Different dialects of EFSMs are widely used in tools for model-based software development, verification, and testing. Our algorithm infers a class of EFSMs called register automata. Register automata have a finite control structure, extended with variables (registers), assignments, and guards. Our algorithm is parameterized on a particular theory, i.e., a set of operations and tests on the data domain that can be used in guards.Key to our learning technique is a novel learning model based on so-called tree queries. The learning algorithm uses tree queries to infer symbolic data constraints on parameters, e.g., sequence numbers, time stamps, identifiers, or even simple arithmetic. We describe sufficient conditions for the properties that the symbolic constraints provided by a tree query in general must have to be usable in our learning model. We also show that, under these conditions, our framework induces a generalization of the classical Nerode equivalence and canonical automata construction to the symbolic setting. We have evaluated our algorithm in a black-box scenario, where tree queries are realized through (black-box) testing. Our case studies include connection establishment in TCP and a priority queue from the Java Class Library. 相似文献