Lightpath (wavelength) routing in large WDM networks

We address the problem of efficient circuit switching in wide area optical networks. The solution provided is based on finding optimal routes for lightpaths and the new concept of semilightpaths. A lightpath is a fully optical transmission path, while a semilightpath is a transmission path constructed by chaining together several lightpaths, using wavelength conversion at their junctions. A fast and practical algorithm is presented to optimally route lightpaths and semilightpaths taking into account both the cost of using the wavelengths on links and the cost of wavelength conversion. We prove that the running time of the algorithm is the best possible in the wide class of algorithms allowing linear algebraic operations on weights. This class encompasses all known related practical methods. Additionally, our method works for any physical realization of wavelength conversion, independently whether it is done via optoelectronic conversion or in a fully optical way     

Platinum concentrations in urban road dust and soil, and in blood and urine in the United Kingdom

Increasing Pt concentrations from vehicle catalysts have been reported from a number of countries. Analysis of Pt and Pd in soils and road dusts taken from areas of high and low traffic flows in SE England show concentrations of Pt in the range < 0.30-40.1 ng g-1 and Pd in the range < 2.1-57.9 ng g-1. Higher concentrations of Pt are associated with high traffic densities. Samples taken from streets of lower traffic flows were found to contain the lower concentrations of the ranges. Pilot studies of Pt concentrations in blood and urine using ICP-MS have been carried out. Platinum concentrations in whole blood were: precious metal workers, 780-2170, mean 1263 pmol l-1 (0.152-0.423, mean 0.246 microgram l-1); motorway maintenance workers, 645-810, mean 744 pmol l-1 (0.126-0.158, mean 0.145 microgram l-1); Imperial College staff, 590-713, mean 660 pmol l-1 (0.115-0.139, mean 0.129 microgram l-1). Platinum concentrations in urine in pmol Pt per mmol creatinine were: precious metal workers, 122-682, mean 273 [0.21-1.18, mean 0.47 microgram Pt (g creatinine)-1]; motorway maintenance workers, 13-78, mean 33.7 [0.022-0.135, mean 0.058 microgram Pt (g creatinine)-1]; Imperial College staff, 28-130, mean 65.6 [0.048-0.224, mean 0.113 microgram Pt (g creatinine)-1]. Detection limits were 0.03 microgram l-1 for both blood and urine. The possible health effects of increasing Pt in the environment are discussed. Platinum provides an excellent example of the significance of speciation in metal toxicity. Platinum allergy is confined to a small group of charged compounds that contain reactive ligand systems, the most effective of which are chloride ligand systems. Metallic Pt is considered to be biologically inert and non allergenic and since the emitted Pt is probably in the metallic or oxide form, the sensitising potential is probably very low. Platinum from road dusts, however, can be solubilised, and enter waters, sediments, soils and the food chain. There is at present no evidence for any adverse health effects from Pt in the general environment, particularly allergic reactions.     

Strong universal consistency of neural network classifiers

In statistical pattern recognition, a classifier is called universally consistent if its error probability converges to the Bayes-risk as the size of the training data grows for all possible distributions of the random variable pair of the observation vector and its class. It is proven that if a one-layered neural network with properly chosen number of nodes is trained to minimize the empirical risk on the training data, then a universally consistent classifier results. It is shown that the exponent in the rate of convergence does not depend on the dimension if certain smoothness conditions on the distribution are satisfied. That is, this class of universally consistent classifiers does not suffer from the curse of dimensionality. A training algorithm is presented that finds the optimal set of parameters in polynomial time if the number of nodes and the space dimension is fixed and the amount of training data grows     

Letter

It is a symptom of a far-reaching intellectual, political and economic crisis that one of the new orthodixies of the early 1990s holds that governments cannot, or should not, invest in public works and infrastructure as they did in the ‘good old days’. The reasons usually advanced include everything from such ‘facts’ as the high level of government debt, the staggering level of government deficit, the record of governmental financial mismanagement in the 1980s, the lack of confidence by the financial markets in governments, the worldwide shortage of investment capital and the political ‘unreality’ or ‘unwisdom’ of governments adding further to State debt.     

Making transmission schedules immune to topology changes inmulti-hop packet radio networks

Transmissions scheduling is a key design problem in packet radio networks, relevant to TDMA and CDMA systems. A large number of topology-dependent scheduling algorithms are available, in which changes of topology inevitably require recomputation of transmission schedules. The need for constant adaptation of schedules to mobile topologies entails significant, sometime insurmountable, problems. These are the protocol overhead due to schedule recomputation, performance penalty due to suspension of transmissions during schedule reorganization, exchange of control message and new schedule broadcast. Furthermore, if topology changes faster than the rate at which new schedules can be recomputed and distributed, the network can suffer a catastrophic failure. The authors propose a robust scheduling protocol which is unique in providing a topology transparent solution to scheduled access in multi-hop mobile radio networks. The proposed solution adds the main advantages of random access protocols to scheduled access. Similarly to random access it is robust in the presence of mobile nodes. Unlike random access, however, it does not suffer from inherent instability, and performance deterioration due to packet collisions. Unlike current scheduled access protocols, the transmission schedules of the proposed solution are independent of topology changes, and channel access is inherently fair and traffic adaptive     

Hemodynamic effect of plasma DNA

To reveal the hemodynamic effect of plasma DNA, the authors measured the concentrations of plasma DNA, the length of its molecular fragments, and hemodynamic resistance/Toms effect. The Toms effect was detected in all blood samples from 10 healthy donors and 39 patients without acute stroke caused by atherosclerosis of the head great arteries with and without arterial hypertension. There was a clear inverse relationships between the plasma concentrations of DNA which had only long-molecular fragments in healthy persons and the hemodynamic resistance of its blood flow samples. The patient blood plasma had significant increased DNA concentrations but their molecular fragments were long and short. Inverse relationships between the plasma DNA concentration and the hemodynamic resistance of the patients' blood flow samples had a less correlation coefficient due to the high proportion of short DNA molecular fragments. The Toms effect was shown in the DNA solution prepared only from human funic blood where the DNA molecular fragments were long. The Toms effect was absent in the solutions prepared from the commercial cattle or salmon sperm DNA which contained shorter DNA molecular fragments. It is concluded that plasma DNA has a hemodynamic effect and the origin of long-molecular fragments of DNA which is typical for healthy young persons and short DNA molecular fragments that additionally appear in patients with vascular disorders is different.     

Anatomy,micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

This article enumerates the detailed anatomy of Cantinoa althaeifolia (Lamiaceae) illustrated with light and scanning electron microscopy images. The anatomical markers include the presence of branched nonglandular trichomes and capitate, peltate, and clavate types of glandular trichomes; prismatic crystals on the leaf and stem surfaces; and oil droplets in the leaf mesophyll. Histochemical tests and EDS analyses were performed in order to detect the composition of certain cells and their contents. The key findings of the present study can contribute to the taxonomy, species identification, and quality control of Cantinoa althaeifolia.     

Evaluation of oral carvedilol microparticles prepared by simple emulsion technique using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone as polymers

Polymeric microparticles containing carvedilol (CRV) were obtained successfully using a simple emulsion/organic evaporating method. Three different formulations were developed using poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and polycaprolactone (PCL) as polymers; the resulting samples were submitted to physical–chemical characterization and in vivo evaluation. The physical–chemical analysis indicated that the PHBV promoted a porous aspect in the microparticle's surface, while PCL a smooth aspect. The PCL-CRV microparticles showed a higher loading efficiency and a longer drug release time, being selected for in vivo evaluation. The in vivo assays indicated that PCL-CRV polymeric microparticles has a pharmacological antihypertensive effect for a longer period of time, representing a good alternative to improved the life quality of the patient that uses this drug.