In situ measurements of human cough aerosol hygroscopicity

The airborne dynamics of respiratory droplets, and the transmission routes of pathogens embedded within them, are governed primarily by the diameter of the particles. These particles are composed of the fluid which lines the respiratory tract, and is primarily mucins and salts, which will interact with the atmosphere and evaporate to reach an equilibrium diameter. Measuring organic volume fraction (OVF) of cough aerosol has proved challenging due to large variability and low material volume produced after coughing. Here, the diametric hygroscopic growth factors (GF) of the cough aerosol produced by healthy participants were measured in situ using a rotating aerosol suspension chamber and a humidification tandem differential mobility analyser. Using hygroscopicity models, it was estimated that the average OVF in the evaporated cough aerosol was 0.88 ± 0.07 and the average GF at 90% relative humidity (RH) was 1.31 ± 0.03. To reach equilibrium in dry air the droplets will reduce in diameter by a factor of approximately 2.8 with an evaporation factor of 0.36 ± 0.05. Hysteresis was observed in cough aerosol at RH = ∼35% and RH = ∼65% for efflorescence and deliquescence, respectively, and may depend on the OVF. The same behaviour and GF were observed in nebulized bovine bronchoalveolar lavage fluid.     

Mechanics of plain-woven fabrics for inflated structures

Pressurized fabric tubes, pressure-stabilized beams (known as air beams) and air-inflated structures are considered to be valuable technologies for lightweight, rapidly deployable structures. Design optimization of an inflated structure depends on a thorough understanding of woven fabric mechanics. In this paper the bending response of woven pressure-stabilized beams have been experimentally tested and analytically investigated. Additionally, the micromechanical effects of interacting tows have been studied through finite element models containing contact surfaces and nonlinear slip/stick conditions. Local unit cell models consisting of pairs of woven tows were created to characterize the effective constitutive relations. The material properties from the unit cell models were then used for the global continuum model subjected to 4-point flexure. An experimental set-up was designed and manufactured for testing of Vectran and PEN air beams. The air beam mid-span deflections were measured as functions of inflation pressure and bending load. Plots of the elastic and shear moduli with respect to the pressure and coefficient of friction have been generated. It was determined that the effective elastic and shear moduli were functions of inflation pressure, the material used and the geometry of the weave. It was shown that pneumatic or pressurized tube structures differ fundamentally from conventional metal structures.     

Analytical Modeling of Short-Channel Fully-Depleted Triple Work Function Metal Gate (TWFMG) SOI MESFET

Silicon - In this paper, a new structure: triple work function metal gate SOI MESFET, intended for integration into the deep-submicron CMOS technology, is proposed. The gate of the device consists...     

Experimental determination of gas holdup and volumetric mass transfer coefficient in a jet bubbling reactor

The hydrodynamics and mass transfer characteristics of a lab-scale jet bubbling reactor(JBR) including the gas holdup, volumetric mass transfer coefficient and specific interfacial area were assessed experimentally investigating the influence of temperature, p H and superficial gas velocity. The reactor diameter and height were 11 and 30 cm,respectively. It was equipped with a single sparger, operating at atmospheric pressure, 20 and 40℃, and two p H values of 3 and 6. The height of the liquid was 23 cm, while the superficial gas velocity changed within 0.010–0.040 m·s~(-1) range. Experiments were conducted with pure oxygen as the gas phase and saturated lime solution as the liquid phase. The liquid-side volumetric mass transfer coefficient was determined under unsteady-state oxygen absorption in a saturated lime solution. The gas holdup was calculated based on the liquid height change, while the specific interfacial area was obtained by a physical method based on the bubble size distribution(BSD) in different superficial gas velocities. The results indicated that at the same temperature but different p H, the gas holdup variation was negligible, while the liquid-side volumetric mass transfer coefficient at the p H value of 6 was higher than that at the p H = 3. At a constant p H but different temperatures, the gas holdup and the liquid-side volumetric mass transfer coefficients at 40℃ were higher than that of the same at 20℃. A reasonable and appropriate estimation of the liquid-side volumetric mass transfer coefficient(kla) in a pilot-scale JBR was provided which can be applied to the design and scale-up of JBRs.     

Biosynthesis of SeNPs by Mycobacterium bovis and their enhancing effect on the immune response against HBs antigens: an in vivo study

Conventional hepatitis B vaccine contains alum but is less effective to induce Th1 response. Selenium nanoparticles and Bacillus Calmette–Guerin were reported as immune modulators. In this study, SeNPs were extracted from Mycobacterium bovis and characterised. SeNPs were mixed with HBs‐Ag and administered to the mice to investigate he immune response pattern. With an addition of Se ions at a sub‐inhibitory concentration to the Sauton medium broth after 24 h, SeNPs were extracted from M. bovis and characterised by Fourier transform infrared spectroscopy, dynamic light scattering, atomic forcemicroscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, and thermogravimetric analysis. Furthermore, female inbred BALB/c mice were injected subcutaneously on the first, 14th, 28th day with 100 and 200 µg doses of that SeNPs supplemented with HBs‐Ag vaccine. Later, the total antibody, isotypes of Immunoglobulin G1, Interlukin 4, and interferon‐γ were measured by enzye‐linked immunosorbent assay. The size of the SeNPs was <150 nm. Level of total antibody and immunoglobulin G2a increased significantly in the group that received 200 µg/ml nano selenium extracted from M. bovis. SeNPs in dose of 200 µg coated with organic materials of M. bovis could induce an influential immune response in relation to the conventional HBs‐Ag vaccine.Inspec keywords: selenium, nanoparticles, nanofabrication, microorganisms, Fourier transform spectra, infrared spectra, light scattering, atomic force microscopy, X‐ray chemical analysis, transmission electron microscopy, thermal analysis, nanomedicineOther keywords: biosynthesis, selenium nanoparticles, Mycobacterium bovis, enhnced immune response, HBs antigens, Bacillus Calmette‐Guerin, immune modulators, biogenic SeNPs, immune response pattern, Sauton medium broth, Fourier transform infrared spectroscopy, dynamic light scattering, atomic force microscopy, energy dispersive X‐ray spectrum, transmission electron microscopy, thermogravimetric analysis, female inbred BALB/c mice, antibody, IgG1 isotype, IgG2a isotype, IL₄ isotype, interferon‐γ, enzyme‐linked immunosorbent assay, bacterium, time 24 h, time 14 day, time 28 day, Se     

A memetic algorithm for minimizing the total weighted completion time on a single machine under step-deterioration

In this paper, we consider minimizing total weighted completion time criteria on a single machine. Jobs processing times are step function of its starting time and all jobs have a common due date. First, we present some new lemmas and dominance properties for this NP-hard problem, and then a memetic algorithm using these properties is developed. We compare the solutions of the memetic algorithm with optimal solutions obtained from complete enumeration. The results show that the average percentage error of the proposed algorithm from optimal solutions is about 2% and as the variance of processing time increase, the percentage errors decrease.     

Analysis of a clock synchronization protocol for wireless sensor networks

The Dutch company Chess develops a wireless sensor network (WSN) platform using an epidemic communication model. One of the greatest challenges in the design is to find suitable mechanisms for clock synchronization. In this paper, we study a proposed clock synchronization protocol for the Chess platform. First, we model the protocol as a network of timed automata and verify various instances using the Uppaal model checker. Next, we present a full parametric analysis of the protocol for the special case of cliques (networks with full connectivity), that is, we give constraints on the parameters that are both necessary and sufficient for correctness. These results have been checked using the proof assistant Isabelle. We report on the exhaustive analysis of the protocol for networks with four nodes, and we present a negative result for the special case of line topologies: for any instantiation of the parameters, the protocol will eventually fail if the network grows.     

Interaction between refractory crucible materials and the melted NiTi shape-memory alloy

Attempts have been made to quantify the amount of contaminants absorbed by liquid metal from commercial ZrO₂-, Al₂O₃-, and SiC-base crucibles used for vacuum melting of Ni-45 wt pct Ti alloy. The molten alloy was held under vacuum for 90 minutes at 1450 °C to become homogenized. Reactions between the liquid metal and the crucible were investigated by visual observation, chemical analysis, scanning electron microscopy (SEM) image processing, and X-ray mapping. The relative degree of contamination declined in the following sequence: commercially pure SiC>SiC-5 wt pct Al₂O₃-5 wt pct SiO₂>slurry cast alumina>recrystallized alumina>zircon type A>oxygen deficient high-purity zirconia. Thermodynamic calculations showed a difference between the equilibrium and the experimental data, indicating that except for commercially pure SiC crucible, the amount of the crucible elements entering the melt is greater than the calculated equilibrium values. This discrepancy seems to be due to the immersion into the melt of the undissolved chemical compounds formed due to the reactions between the crucible and the liquid phase.     

Optimal random perturbations for stochastic approximation using asimultaneous perturbation gradient approximation

The simultaneous perturbation stochastic approximation (SPSA) algorithm has attracted considerable attention for challenging optimization problems where it is difficult or impossible to obtain a direct gradient of the objective (say, loss) function. The approach is based on a highly efficient simultaneous perturbation approximation to the gradient based on loss function measurements. SPSA is based on picking a simultaneous perturbation (random) vector in a Monte Carlo fashion as part of generating the approximation to the gradient. This paper derives the optimal distribution for the Monte Carlo process. The objective is to minimize the mean square error of the estimate. The authors also consider maximization of the likelihood that the estimate be confined within a bounded symmetric region of the true parameter. The optimal distribution for the components of the simultaneous perturbation vector is found to be a symmetric Bernoulli in both cases. The authors end the paper with a numerical study related to the area of experiment design