排序方式: 共有72条查询结果,搜索用时 15 毫秒
1.
Jan Haas Karen S. Frese Farbod Sedaghat-Hamedani Elham Kayvanpour Rewati Tappu Rouven Nietsch Oguz Firat Tugrul Michael Wisdom Carsten Dietrich Ali Amr Tanja Weis Torsten Niederdrnk Michael P. Murphy Thomas Krieg Marcus Drr Uwe Vlker Jens Fielitz Norbert Frey Stephan B. Felix Andreas Keller Hugo A. Katus Benjamin Meder 《International journal of molecular sciences》2021,22(4)
With more than 25 million people affected, heart failure (HF) is a global threat. As energy production pathways are known to play a pivotal role in HF, we sought here to identify key metabolic changes in ischemic- and non-ischemic HF by using a multi-OMICS approach. Serum metabolites and mRNAseq and epigenetic DNA methylation profiles were analyzed from blood and left ventricular heart biopsy specimens of the same individuals. In total we collected serum from n = 82 patients with Dilated Cardiomyopathy (DCM) and n = 51 controls in the screening stage. We identified several metabolites involved in glycolysis and citric acid cycle to be elevated up to 5.7-fold in DCM (p = 1.7 × 10−6). Interestingly, cardiac mRNA and epigenetic changes of genes encoding rate-limiting enzymes of these pathways could also be found and validated in our second stage of metabolite assessment in n = 52 DCM, n = 39 ischemic HF and n = 57 controls. In conclusion, we identified a new set of metabolomic biomarkers for HF. We were able to identify underlying biological cascades that potentially represent suitable intervention targets. 相似文献
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Experimental test of a robust formation controller for marine unmanned surface vessels 总被引:1,自引:0,他引:1
Daniel Schoerling Chris Van Kleeck Farbod Fahimi Charles Robert Koch Alfons Ams Peter Löber 《Autonomous Robots》2010,28(2):213-230
Experiments with two formation controllers for marine unmanned surface vessels are reported. The formation controllers are
designed using the nonlinear robust model-based sliding mode approach. The marine vehicles can operate in arbitrary formation
configurations by using two leader-follower control schemes. For the design of these controller schemes 3 degrees of freedom
(DOFs) of surge, sway, and yaw are assumed in the planar motion of the marine surface vessels. Each vessel only has two actuators;
therefore, the vessels are underactuated and the lack of a kinematic constraint puts them into the holonomic system category.
In this work, the position of a control point on the vessel is controlled, and the orientation dynamics is not directly controlled.
Therefore, there is a potential for an oscillatory yaw motion to occur. It is shown that the orientation dynamics, as the
internal dynamics of this underactuated system, is stable, i.e., the follower vehicle does not oscillate about its control
point during the formation maneuvers. The proposed formation controller relies only on the state information obtained from
the immediate neighbors of the vessel and the vessel itself. The effectiveness and robustness of formation control laws in
the presence of parameter uncertainty and environmental disturbances are demonstrated by using both simulations and field
experiments. The experiments were performed in a natural environment on a lake using a small test boat, and show robust performance
to parameter uncertainty and disturbance. This paper reports the first experimental verification of the above mentioned approach,
whose unique features are the use of a control point, the zero-dynamic stability analysis, the use of leader-follower method
and a nonlinear robust control approach. 相似文献
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The main recognition procedure in modern HMM-based continuous speech recognition systems is Viterbi algorithm. Viterbi algorithm finds out the best acoustic sequence according to input speech in the search space using dynamic programming. In this paper, dynamic programming is replaced by a search method which is based on particle swarm optimization. The major idea is focused on generating initial population of particles as the speech segmentation vectors. The particles try to achieve the best segmentation by an updating method during iterations. In this paper, a new method of particles representation and recognition process is introduced which is consistent with the nature of continuous speech recognition. The idea was tested on bi-phone recognition and continuous speech recognition workbenches and the results show that the proposed search method reaches the performance of the Viterbi segmentation algorithm ; however, there is a slight degradation in the accuracy rate. 相似文献
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Various zinc oxide nanostructures were synthesized using thermal decomposition of zinc acetate dihydrate in a single process. The characterization of samples using powder X-ray diffraction, scanning electron microscope and FT-IR measurements revealed that the pure phase of different morphologies such as nanoparticles, nanowires and nanodisks had been synthesized successfully. Surprisingly some synthesized ZnO nanostructures were dark gray. The results showed that the reason may have been related to the oxygen deficiency and strong asymmetric stretching mode of wurtzite ZnO nanostructure. Using such samples, the photodegradation of Methylene blue was performed by UV–vis absorption measurement and the effect of morphology on the photocatalytic properties of different ZnO nanostructures was examined. The results showed that the nanodisks had the best photocatalytic performance among the other morphologies. The reason was attributed to the presence of specific crystal planes such as (0001) facets in nanodisks which can improve their photocatalytic performance. 相似文献
6.
Mergen H. Ghayesh Farbod Alijani Mohammad A. Darabi 《Journal of Mechanical Science and Technology》2011,25(8):1915-1923
The aim of this study is to develop an approximate analytic solution for nonlinear dynamic response of a simply-supported
Kelvin-Voigt viscoelastic beam with an attached heavy intra-span mass. A geometric nonlinearity due to midplane stretching
is considered and Newton’s second law of motion along with Kelvin-Voigt rheological model, which is a two-parameter energy
dissipation model, are employed to derive the nonlinear equations of motion. The method of multiple timescales is applied
directly to the governing equations of motion, and nonlinear natural frequencies and vibration responses of the system are
obtained analytically. Regarding the resonance case, the limit-cycle of the response is formulated analytically. A parametric
study is conducted in order to highlight the influences of the system parameters. The main objective is to examine how the
vibration response of a plain (i.e. without additional adornment) beam is modified by the presence of a heavy mass, attached
somewhere along the beam length. 相似文献
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Vahid Ghods Ehsanollah Kabir Farbod Razzazi 《Engineering Applications of Artificial Intelligence》2013,26(1):544-550
Online handwriting is formed by a combination of horizontal and vertical trajectories. If these trajectories are treated separately, new recognition methods are emerged. In contrast, one classifier is often used to recognize handwriting. In this work, some features for x(t) and y(t) signals were proposed and used to make two separate classifiers. After initial recognition by these classifiers, their results were fused for final recognition. Using HMM classifiers and simple product rule for decision fusion, the recognition results of 42 classes of Farsi subwords showed promising achievements. 相似文献
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The multidimensional multiple-choice knapsack problem (MMKP) is an extension of the 0–1 knapsack problem. The core concept has been used to design efficient algorithms for the knapsack problem but the core has not been developed for the MMKP so far. In this paper, we develop an approximate core for the MMKP and utilize it to solve the problem exactly. 相似文献
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Samples of Hg-1201 have been synthesized using the sealed-tube precursor-reactant method. The samples are mercury deficient, with the deficiency related to the ratio of precursor to reactant mass in the tube. The Curie constant in the normal state is found to evolve systematically with mercury content in a way that suggests a combination of structural mercury vacancies and phase segregation. Thermopower measurements are presented for samples over a range of doping levels. 相似文献
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This paper addresses the application of quantum entanglement and cryptography for automation and control of dynamic systems.A dynamic system is a system where t... 相似文献