Group decision-making based on pythagorean fuzzy TOPSIS method

Group decision-making is a process wherein multiple individuals interact simultaneously, analyze problems, evaluate the possible available alternatives, characterized by multiple conflicting criteria, and choose suitable alternative solution to the problem. Technique for establishing order preference by similarity to the ideal solution (TOPSIS) is a well-known method for multiple-criteria decision-making. The purpose of this study is to extend the TOPSIS method to solve multicriteria group decision-making problems equipped with Pythagorean fuzzy data, in which the assessment information on feasible alternatives, provided by the experts, is presented as Pythagorean fuzzy decision matrices having each entry characterized by Pythagorean fuzzy numbers. A revised closeness index is utilized to obtain the ranking of alternatives and to identify the optimal alternative. The developed Pythagorean fuzzy TOPSIS (PF-TOPSIS) is illustrated by a flow chart. At length, practical examples interpreting the applicability of our proposed PF-TOPSIS are solved.     

Faster and Protective Wound Healing Mechanistic of Para-Coumaric Acid Loaded Liver ECM Scaffold Cross-linked with Acellular Marine Kelp

Decellularized liver-derived extracellular matrix is a unique combination of a complex milieu of growth factors and proteins that stimulate biochemical, physical, and mechanical cues to the cells. However, the lack of mechanical strength hindering the applicability of extracellular matrix (ECM) is an outstanding challenge. Herein, to deal with this problem, decellularized kelp is introduced as a crosslinking material thereby strengthening the physical structure of ECM for its utilization as a wound-healing material. Consequently, a significant architectural change is observed in the ECM by forming a solid-shaped scaffold. Nevertheless, the hindrance of high pH is addressed by incorporating the acidic drug p-coumaric acid. To evaluate the innate regenerative abilities, the scaffolds are applied to rat excisional wounds. A remarkable wound healing capability is demonstrated by both the EK scaffolds, but a faster regeneration is achieved with only EK-20@cou. The speculated hypothesis is that the incorporation of p-coumaric acid can offer many additional bioactive benefits to the scaffold such as remarkable biocompatibility, antioxidant, and anti-bacterial properties that are deliberately supported by the in vitro results. In silico molecular simulations (MS) validated that p-Cou released from the EK-20@Cou scaffold is accountable for the observed extraordinary regenerative behavior as compared to EK-20(PW).