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1.
We have localized gene MSS51 on chromosome XII of Saccharomyces cerevisiae between the RDN1 and CDC42 loci. 'Head to head' with MSS51 is another gene, QRI5, the function of which is unknown. However, the proximity of these genes, the structure of the intergenic region and the presence of an ABF1 binding site right in the middle of this region suggest that the MSS51 and QRI5 expressions are submitted to a common regulatory process. 相似文献
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Munsif Ali Jatoi Nidal Kamel Aamir Saeed Malik Ibrahima Faye Jose M. Bornot Tahamina Begum 《International journal of imaging systems and technology》2016,26(1):55-64
Electroencephalography (EEG) is widely used in variety of research and clinical applications which includes the localization of active brain sources. Brain source localization provides useful information to understand the brain's behavior and cognitive analysis. Various source localization algorithms have been developed to determine the exact locations of the active brain sources due to which electromagnetic activity is generated in brain. These algorithms are based on digital filtering, 3D imaging, array signal processing and Bayesian approaches. According to the spatial resolution provided, the algorithms are categorized as either low resolution methods or high resolution methods. In this research study, EEG data is collected by providing visual stimulus to healthy subjects. FDM is used for head modelling to solve forward problem. The low‐resolution brain electromagnetic tomography (LORETA) and standardized LORETA (sLORETA) have been used as inverse modelling methods to localize the active regions in the brain during the stimulus provided. The results are produced in the form of MRI images. The tables are also provided to describe the intensity levels for estimated current level for the inverse methods used. The higher current value or intensity level shows the higher electromagnetic activity for a particular source at certain time instant. Thus, the results obtained demonstrate that standardized method which is based on second order Laplacian (sLORETA) in conjunction with finite difference method (FDM) as head modelling technique outperforms other methods in terms of source estimation as it has higher current level and thus, current density (J) for an area as compared to others. 相似文献
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Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers worldwide. More than half of patients with HNSCC eventually experience disease recurrence and/or metastasis, which can threaten their long-term survival. HNSCCs located in the oral cavity and larynx are usually associated with tobacco and/or alcohol use, whereas human papillomavirus (HPV) infection, particularly HPV16 infection, is increasingly recognized as a cause of oropharyngeal HNSCC. Despite clinical, histologic, and molecular differences between HPV-positive and HPV-negative HNSCCs, current treatment approaches are the same. For recurrent disease, these strategies include chemotherapy, immunotherapy with PD-1-inhibitors, or a monoclonal antibody, cetuximab, that targets epidermal growth factor; these therapies can be administered either as single agents or in combination. However, these treatment strategies carry a high risk of toxic side effects; therefore, more effective and less toxic treatments are needed. The landscape of HNSCC therapy is changing significantly; numerous clinical trials are underway to test novel therapeutic options like adaptive cellular therapy, antibody-drug conjugates, new targeted therapy agents, novel immunotherapy combinations, and therapeutic vaccines. This review helps in understanding the various developments in HNSCC therapy and sheds light on the path ahead in terms of further research in this field. 相似文献
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Irene R. Grant Antonio C.G. Foddai James C. Tarrant Brenna Kunkel Faye A. Hartmann Sheila McGuirk Chungyi Hansen Adel M. Talaat Michael T. Collins 《Journal of dairy science》2017,100(12):9723-9735
When advising farmers on how to control Johne's disease in an infected herd, one of the main recommendations is to avoid feeding waste milk to calves and instead feed calf milk replacer (CMR). This advice is based on the assumption that CMR is free of viable Mycobacterium avium ssp. paratuberculosis (MAP) cells, an assumption that has not previously been challenged. We tested commercial CMR products (n = 83) obtained from dairy farms around the United States by the peptide-mediated magnetic separation (PMS)-phage assay, PMS followed by liquid culture (PMS-culture), and direct IS900 quantitative PCR (qPCR). Conventional microbiological analyses for total mesophilic bacterial counts, coliforms, Salmonella, coagulase-negative staphylococci, streptococci, nonhemolytic Corynebacterium spp., and Bacillus spp. were also performed to assess the overall microbiological quality of the CMR. Twenty-six (31.3%) of the 83 CMR samples showed evidence of the presence of MAP. Seventeen (20.5%) tested positive for viable MAP by the PMS-phage assay, with plaque counts ranging from 6 to 1,212 pfu/50 mL of reconstituted CMR (average 248.5 pfu/50 mL). Twelve (14.5%) CMR samples tested positive for viable MAP by PMS-culture; isolates from all 12 of these samples were subsequently confirmed by whole-genome sequencing to be different cattle strains of MAP. Seven (8.4%) CMR samples tested positive for MAP DNA by IS900 qPCR. Four CMR samples tested positive by both PMS-based tests and 5 CMR samples tested positive by IS900 qPCR plus one or other of the PMS-based tests, but only one CMR sample tested positive by all 3 MAP detection tests applied. All conventional microbiology results were within current standards for whole milk powders. A significant association existed between higher total bacterial counts and presence of viable MAP indicated by either of the PMS-based assays. This represents the first published report of the isolation of viable MAP from CMR. Our findings raise concerns about the potential ability of MAP to survive manufacture of dried milk-based products. 相似文献
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S Diallo L Konate O Faye O Ndir M Faye A Gueye M Diouf 《Canadian Metallurgical Quarterly》1998,91(3):259-263
This study aimed to investigate the cause of persistently increased serum gastrin concentration seen in some Graves' disease patients even when euthyroid during antithyroid drug treatment. The subjects studied consisted of three groups: 33 patients with a common-type of Graves' disease, 14 with triiodothyronine (T3)-predominant Graves' disease (characterized from previous studies as having potent immunologic abnormalities including greater concentrations of thyroid-stimulating antibodies together with larger goiter size), and a group of 20 normal subjects. Fasting serum gastrin concentrations in common Graves' disease patients were significantly higher than those of normal subjects (58.4 +/- 38.9 pmol/L vs. 37.8 +/- 18.9 pmol/L [mean +/- SD], p < 0.05). The serum gastrin concentrations were even greater in T3-predominant Graves' disease patients than common Graves' disease patients (162.9 +/- 224.0 pmol/L vs. 58.4 +/- 38.9 pmol/L, p < .05). Serum pepsinogen I (PGI) concentrations were significantly lower in the T3-predominant patient group than the common Graves' group (24.0 +/- 12.9 ng/mL vs. 39.7 +/- 19.6 ng/mL, p < .05). Serum ratios of PG I to PG II were significantly lower in the T3-predominant Graves' disease patients than normal subjects (3.59 +/- 2.66 vs. 5.97 +/- 1.56, p < .01). The ratios also had a significant (p < .05) inverse correlation with serum gastrin concentrations in T3-predominant Graves' disease patients. The results suggest that autoimmune gastritis is associated with Graves' disease, particularly in patients with potent thyroid-autoimmunity. 相似文献
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M. Kergoat A. Giboreau H. Nicod P. Faye E. Diaz M.A. Beetschen N. Gerritsen T. Meyer 《Food quality and preference》2010,21(2):178-187
The aim of this study is to explore psychological and psychosocial individual differences in order to understand heterogeneous sensory preference clusters identified in consumer tests. We conducted two studies with 100 participants in each. Six seat car fabrics were rated on liking items. A questionnaire composed of the Affect Intensity Measure (AIM) [Larsen, R. J. (1984). Theory and measurement of affect intensity as an individual difference characteristic. Dissertation Abstracts International, 85, 2297B], the Rational-Experiential Inventory (REI), the Iowa–Netherlands Comparison Orientation Scale, (INCOM) [Gibbons, F. X., & Buunk, B. P. (1999). Individual differences in social comparison: Development of a scale of social comparison orientation. Journal of Personality and Social Psychology, 76, 129–142], and the Centrality of Visual Products Aesthetics (CVPA) [Bloch, P. H., Brunel, F. F., & Arnold, T. J. (2003). Individual differences in the centrality of visual product aesthetics: Concept and measurement. Journal of Consumer Research, 29, 551–565] was used. Two clusters of preferences were characterized by the AIM and REI measures. One group, “the velvet fabrics likers”, experienced emotions more intensely than the “non-velvet likers” who in turn, appeared to rely mostly on feelings in the judgment process. We discuss the possible influence of these psychological factors on the significance of sensory input used in the evaluation process. 相似文献