Methotrexate in the management of severe steroid dependent asthma

AIMS: This study was designed to assess the efficacy of low dose methotrexate, 15 mg weekly, as a steroid-sparing agent in asthmatic patients requiring long-term oral prednisone treatment. METHODS: The study was a randomised, double blind, placebo controlled, cross over study of 48 weeks duration. Eleven patients with severe steroid-dependent asthma were included. A successful outcome was defined as a reduction in mean prednisone requirements of 7 mg daily compared to baseline requirements, during active treatment. RESULTS: Two patients were required to be withdrawn owing to methotrexate-related adverse effects. The mean prednisone dose for patients who completed the study was 14.4 mg per day (95% CI; 13.6, 15.1) during active treatment, and 12.9 mg per day (95% CI: 12.2, 13.6) during placebo treatment (NS). Only one patient reduced his individual dose requirements by more than 7 mg per day, whereas in three patients prednisone requirements actually increased during active treatment. There were no significant differences in symptom scores, pulmonary function data, and exacerbations between active and placebo treatments. CONCLUSION: No significant steroid-sparing effect was obtained using low dose methotrexate in this study. This negative outcome may be attributable to the small population of patients studied, low baseline FEV1, and the omission of a steroid minimisation run-in period. Our results highlight the importance of careful patient selection and a painstaking approach in the management of patients with steroid-dependent asthma.     

Adolescent egocentrism and formal operations: Tests of a theoretical assumption.

The theoretical relation between adolescent egocentrism and formal operations was addressed in 2 studies. In Study 1, this relation was assessed with the Adolescent Egocentrism Scale (AES; R. Enright et al, see PA, Vols 63:5127 and 65:10218) and a battery of formal reasoning tasks administered to 183 6th-, 8th-, 10th-, and 12th-graders. The results reveal only significant negative or nonsignificant correlations between the measures in early adolescence. There was also no evidence of significant developmental covariation from early to middle adolescence. The validation effort was extended in Study 2 to include 2 measures of adolescent egocentrism (AES and the Imaginary Audience Scale [IAS; D. Elkind and R. Bowen, see PA, Vol 62:5769]) and a 2nd battery of formal operations problems. These measures were administered to 117 7th-, 9th-, and 11th-graders and to 56 undergraduates. There was once again no evidence of significant developmental covariation among the measures. The correlations between the AES and IAS were modest, reflecting differences in the nature and content of the measures. It is concluded that little support exists in this study or in the literature for the crucial theoretical assumption of adolescent egocentrism. (19 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

On deciding finiteness of matrix groups

We provide a new, practical algorithm for deciding finiteness of matrix groups over function fields of zero characteristic. The algorithm has been implemented in GAP. Experimental results and extensions of the algorithm to any field of zero characteristic are discussed.     

Microwave Rejection Networks

This is an extension of the Bridged-T infinite rejection network idea transformed into microwave concepts. These devices achieve approximately 100db of attenuation with skirt attenuations approximately 5db. The tuning range between 1 KMc and 10 KMc is continuously covered with 4 units at present. Work is continuing to reduce the number of units to 2. Design parameters, performance curves, and application to MILSTD 826 will be discussed.     

Being bicultural: A mixed-methods study of adolescents' implicitly and explicitly measured multiethnic identities.

Understanding how ethnic identities develop in adolescence is currently limited by a reliance on self-report paper-and-pencil measures. This mixed-methods study presents a novel response time measure, the Multiethnic Identities Processing Task (MIPT), to quantify bicultural adolescents' implicit identifications with ethnic and racial identity labels. Eighty-four adolescents (age 14–21 years) of diverse ethnic and racial backgrounds self-identified as bicultural or not bicultural and described their ethnic identities, pride, and ethnic centrality during a brief interview. Participants were assigned to complete either the interview (self-prime) or the MIPT (no prime) first. Results indicate that bicultural adolescents readily endorsed a variety of ethnic and racial labels in the MIPT, reflecting their multifaceted identities. Younger bicultural adolescents showed a large inhibited response to the label “White,” indicating some hesitation in deciding whether the label was “like me” or “not like me.” Heart rate monitoring and qualitative analyses of interviews provide some insight into this pattern of results. Findings are discussed with respect to developmental theory, and the strengths of using both implicit and explicit measures to understand multiethnic identity development in adolescence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Two-dimensional nonsteady viscous flow simulation on the Navier-Stokes Computer miniNode

The needs of large-scale scientific computation are outpacing the growth in performance of mainframe supercomputers. In particular, problems in fluid mechanics involving complex flow simulations require far more speed and capacity than that provided by current and proposed Class VI supercomputers. To address this concern, the Navier-Stokes Computer (NSC) was developed. The NSC is a parallel-processing machine, comprised of individual Nodes, each comparable in performance to current supercomputers. The global architecture is that of a hypercube, and a 128-Node NSC has been designed. New architectural features, such as a reconfigurable many-function ALU pipeline and a multifunction memory-ALU switch, have provided the capability to efficiently implement a wide range of algorithms. Efficient algorithms typically involve numerically intensive tasks, which often include conditional operations. These operations may be efficiently implemented on the NSC without, in general, sacrificing vector-processing speed. To illustrate the architecture, programming, and several of the capabilities of the NSC, the simulation of two-dimensional, nonsteady viscous flows on a prototype Node, called the miniNode, is presented.     

Fourier optical signal processors

Progress in Fourier optical processing techniques is reviewed. Particular emphasis is placed on real-time pattern recognition, which recently has received increased interest as the result of new filter formulations that can be implemented with existing spatial light modulators. Architectures for coherent optical correlation are reviewed, as are the recently reported phase-only filters. Smart filters that attack the inherent distortion sensitivity of correlation, including those suitable for implementation with phase-only modulation, are reviewed. Correlation experiments implementing real-time variation of both input and reference patterns are also reviewed. The potential for successful near-term application of these techniques is examined     

Evaluation of a multicomponent, behaviorally oriented, problem-based "summer school" program for adolescents with diabetes

A 2-week summer school program, combining problem-based learning with behavior therapy, was developed to help adolescents with insulin-dependent diabetes improve their ability to cope with obstacles to dietary management. Ten students participated in a first session, and 9 participated in a second session, serving as a waiting list control group. Outcomes were evaluated pre- and postsession and at a 4-month follow-up using 3-day food diaries, blood glucose data, and paper-and-pencil tests of diabetes-related knowledge, self-efficacy, coping strategies, and general problem solving. Improvements were observed in self-efficacy, problem-solving skills, and self-reported coping strategies. No significant changes were observed in daily intake of fat, cholesterol, calories, mean blood glucose levels or blood glucose variability, and diabetes knowledge. Comparisons between the first group and the waiting list control group do not allow the significant pre-post changes to be clearly attributed to the summer school program.