Bioprinting a cell-laden matrix for bone regeneration: A focused review

Although many efforts have been made to regenerate the bone lesions, existing challenges can be mitigated through the development of tissue engineering scaffolds. However, the weak control on the microstructure of constructs, limitation in preparation of patient-specific and multilayered scaffolds, restriction in the fabrication of cell-laden matrixes, and challenges in preserving the drug/growth factors' efficacy in conventional methods have led to the development of bioprinting technology for regeneration of bone defects. So in this review, conventional 3D printers are classified, then the priority of the different types of bioprinting technologies for the preparation of the cell/growth factor-laden matrixes are focused. Besides, the bio-ink compositions, including polymeric/hybrid hydrogels and cell-based bio-inks are classified according to fundamental and recent studies. Herein, different effective parameters, such as viscosity, rheological properties, cross-linking methods, biodegradation biocompatibility, are considered. Finally, different types of cells and growth factors that can encapsulate in the bio-inks to promote bone repair are discussed, and both in vitro and in vivo achievement are considered. This review provides current and future perspectives of cell-laden bioprinting technologies. The restrictions and challenges are identified, and proper strategies for the development of cell-laden matrixes and high-performance printable bio-inks are proposed.     

AN INTERACTIVE SEARCH ASSISTANT ARCHITECTURE BASED ON INTRINSIC QUERY STREAM CHARACTERISTICS

Search engine query log mining has evolved over time to more like data stream mining due to the endless and continuous sequence of queries known as query stream. In this paper, we propose an online frequent sequence discovery (OFSD) algorithm to extract frequent phrases from within query streams, based on a new frequency rate metric, which is suitable for query stream mining. OFSD is an online, single pass, and real-time frequent sequence miner appropriate for data streams. The frequent phrases extracted by the OFSD algorithm are used to guide novice Web search engine users to complete their search queries more efficiently. YourEye, our online phrase recommender is then introduced. The advantages of YourEye compared with Google Suggest, a service powered by Google for phrase suggestion, is also described. Various characteristics of two specific Web search engine query logs are analyzed and then the query logs are used to evaluate YourEye. The experimental results confirm the significant benefit of monitoring frequent phrases within the queries instead of the whole queries because none-separable items. The number of the monitored elements substantially decreases, which results in smaller memory consumption as well as better performance. Re-ranking the retrieved pages based on past users clicks for each frequent phrase extracted by OFSD is also introduced. The preliminary results show the advantages of the proposed method compared to the similar work reported in Smyth et al.     

UML-CI: A reference model for profiling critical infrastructure systems

The study of critical infrastructure systems organization and behavior has drawn great attention in the recent years. This is in part due to their great influence on the ordinary life of every citizen. In this paper, we study critical infrastructures’ characteristics and propose a reference model based on the Unified Modeling Language (UML). This reference model attempts to provide suitable means for the task of modeling an infrastructure system through offering five major metamodels. We introduce each of these metamodels and explain how it is possible to integrate them into a unique representation to characterize various aspects of an infrastructure system. Based on the metamodels of UML-CI, infrastructure system knowledge bases can be built to aid the process of infrastructure system modeling, profiling, and management.     

Nano levels detection of beryllium by a novel beryllium PVC-based membrane sensor based on 2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetra oxacyclododecine-12-carbaldehyde-12-(2,4-dinitrophenyl)hy

A novel poly(vinyl chloride)-based 2,3,5,6,8,9-hexahydro-1,4,7,10-benzotetra oxacyclododecine-12-carbaldehyde-12-(2,4-dinitrophenyl)hy (PBC) with sodium tetraphenyl borate (NaTPB) as an anion excluder, benzyl acetate (BA), acetophenon (AP) and o-nitrophenyloctyl ether (NPOE) as plasticizing solvent mediators was prepared and investigated as a beryllium selective sensor. The best performance was observed with the membrane having the PVC–NaTPB–NPOE–PBC composition 30%:3%:62%:5%, which worked well over a very wide concentration range (1.0×10⁻⁷ M to 1.0×10⁻¹ M). The sensor exhibits a Nernstian slope of 29.9 mV per decade of Be²⁺ activity. The detection limit of the sensor is 7.0×10⁻⁸ M (630 ppt). The proposed electrode shows excellent discriminating ability toward Be²⁺ ion with regard to alkali, alkaline earth, transition and heavy metal ions. It was successfully applied to the determination of beryllium in a mineral sample.     

Cylindrical functionally graded shell model based on the first order shear deformation nonlocal strain gradient elasticity theory

Microsystem Technologies - In this article, a cylindrical functionally graded shell model is developed in the framework of nonlocal strain gradient theory for the first time. For this purpose, the...     

Fabrication and characterization of highly efficient three component CuBTC/graphene oxide/PSF membrane for gas separation application

Metal organic frameworks (MOFs) with marvelous properties have aroused enormous attention for different application especially gas adsorption and separation. In this regard, fabrication of MOF hybrids with carbon based materials is new strategy to upgrade MOF performance. In this study CuBTC (Copper benzene-1,3,5-tricarboxylic acid)/graphene oxide (GO) composite was synthesized and characterized by BET, SEM, TGA, XRD and FT-IR techniques. Then CuBTC and CuBTC/GO composite were incorporated into polysulfone (PSF) polymer to construct mixed matrix membranes (MMMs). The obtained membranes were characterized by SEM, TGA, XRD and tensile tests and their gas permeability was measured. The results were compared to those of CuBTC/PSF MMMs. It was revealed that CuBTC/GO composite as filler showed superior performance relative to CuBTC. For instance, 15 wt% loading of CuBTC/GO in PSF represented outstanding gas separation behavior while the same loading of CuBTC in PSF deteriorated performance of MMM. Well particle dispersion and favorable polymer-filler interaction were responsible for such observed difference. A high H₂/CH₄ and H₂/N₂ selectivity of 80.03 and 70.46 were recorded for CuBTC/GO in PSF (15 wt%) compared to 44.56 and 40.92 for CuBTC in PSF (15 wt%).     

Physical and Morphological Properties of Combined Treated Wood Polymer Composites by Maleic Anhydride and Methyl Methacrylate

Wood polymer composites were prepared by consecutive impregnation with maleic anhydride (MAN) and methyl methacrylate (MMA). Samples impregnated with MAN alone, were heated at 120°C and 150°C for 4 and 8 h. Based on the Fourier transform infrared (FT-IR) analysis and soaking-drying test results, treatment with MAN at 150°C for 4 h resulted in formation of stable crosslinks. In the second stage, MMA was used for in situ polymerization within MAN-treated wood. Field emission scanning electron microscopy observation and FT-IR analysis indicated that MMA copolymerized with MAN, and the resultant polymer filled up the lumen and is also grafted on to the cell wall. Improvement of water repellency and dimensional stability were observed in the treated samples, particularly in combined treated samples. The MAN/MMA treatment improved interaction between polymer and wood.     

Hybrid solar parabolic dish power plant and high‐temperature phase change material energy storage system

In this study, a conventional steam power plant with two regenerative boilers is considered, and one of its boilers is replaced with parabolic solar dish collectors and storing the produced thermal energy by the phase change material (PCM) in a storage tank. The results show the necessity of the existence of an auxiliary fired‐gas boiler to provide constant load during the whole 24 hours. The performance of the proposed hybridized system is evaluated through energy and exergy analyses. It was demonstrated that substituting solar collectors with one of the boilers marginally lowers the energy efficiency but increases the exergy efficiency of the whole power plant up to 41.76%. Moreover, it is found out that this hybridization decreases the total irreversibility of the power plant in comparison with the base case, from 51.1 to 47.2 MW. The parametric analysis states that raising the mass flow rate of the heat transfer fluid in the solar collectors not only enhances the system performance but also increases the volume of the PCM tank.     

Describing a strategy to estimate the CO2-heavy oil minimum miscibility pressure based on the experimental methods

To measure MMP, slim tube method is time consuming, especially for heavy oils. In this study, a strategy is considered to measure the MMP in one of the Iranian heavy oil reservoirs. The strategy steps were done through; partial data of slim tube, coupling numerical model (CNM), full slim tube, and VIT test. The results showed that CNM technique with two experimental data obtains the MMP value faster than running a full slim tube with low error result. However, VIT determined MMP faster and its results illustrated that miscibility pressure for heavy oil occurs at zero IFT, unlike light oils.     

Surface decoration of magnetic nanoparticles with folate-conjugated poly(N-isopropylacrylamide-co-itaconic acid): A facial synthesis of dual-responsive nanocarrier for targeted delivery of doxorubicin

The aim of study was to develop a novel drug nanocarrier via facile coating of a folate-conjugated dual-responsive copolymer with carboxylic functional groups on the surface of magnetic nanoparticles for the efficient loading and cell-specific targeting of a positively charged anticancer agent. The nanocarrier exhibited many favorable capabilities such as narrow distributed nano-ranged size (～30 nm), high drug loading capacity (～65%), and stimuli-responsive drug release. The results of various cell cytotoxicity studies such as MTT assay, DAPI staining, and flow cytometry concluded that the developed smart nanocarrier paves a way for efficient cancer therapy by the multiple targeting strategies.