Wire bond loop profile development for fine pitch-long wireassembly

Die size reductions can be achieved through “optical shrinks,” compaction of existing layouts, or redesigns to finer fab geometries. For some die the limiting factors for die size reduction are bond pad pitch and bond pad size. In these “pad limited” designs, the circuitry is concentrated in the center of the die. Precious empty space exists between the bond pads in the periphery of the die and the circuitry in the die core. The only hope for die size reductions in these designs lies in advances in assembly technology that allow for reductions in bond pad pitches and bond pad size. Fine pitch assembly poses a number of challenges for conventional wire bond technology. Reducing bond pad pitch increases the probability of ball shorting, bond wire shorting, and bond wire damage. On the other hand, decreasing the die size by reducing the bond pad pitch results in longer wire lengths thus limiting some assembly options such as moving to smaller diameter bonding wires. Wire loop profile becomes a critical factor for control in fine pitch assembly. In this paper a statistical design of experiment is used in developing a wire bond loop profile control. The effect of major bonding parameters, such as kink-height, reverse loop, loop factor, wire tension, and their impact on loop profile are analyzed. The results obtained define the bond parameter requirements that must be met in order to control the wire loop profile to optimize fine pitch wire bond assembly yields     

Multiechelon Inventory Systems Using Continuous Systems Analysis and Simulation

A methodology based on analysis and simulation techniques, normally used to study control systems, is applied in the analysis of multiechelon inventory systems. First, the inventory systems are modeled as continuous linear systems. From an analytic point of view, the linear models are advantageous because linear systems analysis can be used to reduce the models to transfer functions or input/ output relationships. Second, the restriction of linearity is removed and the resulting nonlinear inventory models are studied by means of a continuous system simulator. Included in this methodology is a procedure for incorporating inventory costs in the dynamic analysis of the system.     

IgG responses to protein-conjugated pneumococcal capsular polysaccharides in persons who are genetically incapable of responding to unconjugated polysaccharides

We have previously shown that the capacity to make IgG to pneumococcal capsular polysaccharides (PCPs) is inherited as an autosomal, mixed codominant trait. The purpose of this study was to determine whether this genetically determined unresponsiveness could be overcome by injection of protein-conjugated pneumococcal vaccines. Seven healthy adults who had failed to produce IgG to five or more of 10 representative PCPs after receiving pneumococcal vaccine and whose parents, siblings, and/or offspring had a similar lack of responsiveness received a series of protein-conjugated polysaccharide vaccines. Excellent IgG responses to most of the PCPs tested were eventually observed in five of the seven subjects after they received octavalent diphtheria toxoid-conjugated vaccine. Administration of certain protein-conjugated PCPs leads to IgG responses in some persons who lack the capacity to respond to unconjugated PCPs.     

Identification of quantitative trait loci influencing wood specific gravity in an outbred pedigree of loblolly pine

We report the identification of quantitative trait loci (QTL) influencing wood specific gravity (WSG) in an outbred pedigree of loblolly pine (Pinus taeda L.). QTL mapping in an outcrossing species is complicated by the presence of multiple alleles (> 2) at QTL and marker loci. Multiple alleles at QTL allow the examination of interaction among alleles at QTL (deviation from additive gene action). Restriction fragment length polymorphism (RFLP) marker genotypes and wood specific gravity phenotypes were determined for 177 progeny. Two RFLP linkage maps were constructed, representing maternal and paternal parent gamete segregations as inferred from diploid progeny RFLP genotypes. RFLP loci segregating for multiple alleles were vital for aligning the two maps. Each RFLP locus was assayed for cosegregation with WSG QTL using analysis of variance (ANOVA). Five regions of the genome contained one or more RFLP loci showing differences in mean WSG at or below the P = 0.05 level for progeny as grouped by RFLP genotype. One region contained a marker locus (S6a) whose QTL-associated effects were highly significant (P > 0.0002). Marker S6a segregated for multiple alleles, a prerequisite for determining the number of alleles segregating at the linked QTL and analyzing the interactions among QTL alleles. The QTL associated with marker S6a appeared to be segregating for multiple alleles which interacted with each other and with environments. No evidence for digenic epistasis was found among the five QTL.     

Etiology and outcome in 42 children with acute nonbacterial meningoencephalitis

In a prospective study of 42 cases of childhood meningoencephalitis occurring in 1974 and 1975, a diagnosis of an infectious agent was made in 30 (71%). California virus infections were most common; they were serious illnesses but had few sequelae. Benign illnesses with enteroviruses were also common. Miscellaneous and unknown agents accounted for the most seriously ill patients and for both deaths. Persistent neurologic deficits were unusual. Headaches, malaise, and changes in behavior were common but transient.