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排序方式: 共有535条查询结果,搜索用时 15 毫秒
1.
Somatic hypermutation of the immunoglobulin variable genes during germinal reactions might permit the expansion of B-cell clones with unwanted (e.g. autoreactive) specificity. Here, Ernst Lindhout and colleagues propose three antigen-specific checkpoints that ensure the appropriate antigen specificity of activated B cells is maintained by regulating the activation, selection and further differentiation of B cells. 相似文献
2.
Evaluation of hydroxylapatite/poly(l-lactide) composites: physico-chemical properties 总被引:7,自引:0,他引:7
C. C. P. M. Verheyen C. P. A. T. Klein J. M. A. De Blieck-Hogervorst J. G. C. Wolke C. A. Van Blitterswijn K. De Groot 《Journal of materials science. Materials in medicine》1993,4(1):58-65
The aim of this in vitro study was to examine the physico-chemical behaviour of hydroxylapatite/poly(l-lactide) (HA/PLLA) composites in solution tests. The polymer PLLA, the composites 30 wt% HA/PLLA (C30) and 50 wt% HA/PLLA (C50) and a one-side HA-coated PLLA (HAcP) were evaluated. Rectangular specimens were incubated in various acellular aqueous buffer solutions [citrate, Gomori's and phosphate-buffered saline (PBS)] up to 24 weeks. Data for cumulative release of calcium, phosphate and l-lactate release in solutions containing C30 or C50 showed linear patterns. Release data for solutions containing HAcP combined with scanning micrographs, X-ray microanalysis and X-ray diffraction patterns of the specimens in time showed that the plasma-sprayed HA coating on PLLA dissolves significantly, progressively in the first weeks and almost completely within the tested period of 24 weeks in vitro. A precipitate of scaly crystallites (calcium phosphates) was observed at the HA coating-PBS interface. After 24 weeks incubation all materials were still above their initial weight, indicating that swelling still exceeded dissolution. Application of C30, C50 and HAcP as implant materials seems interesting where initial stabilization through bone bonding is needed or where the linear release of constituents is a requirement. HAcP has the advantage that the HA coating acts as a hydrolysis barrier and consequently delays the degradation of PLLA in vitro. 相似文献
3.
H. de Groot 《Materialwissenschaft und Werkstofftechnik》2007,38(12):965-968
Ischemia‐reperfusion injury of the bone occurs due to traumatic and non‐traumatic alterations affecting blood supply to the bone. It is likely to occur also upon insertion of an implant. Ischemia‐reperfusion injury of the bone has been studied by interruption of blood supply in situ, in limb replantation/transplantation models, in revascularized bone grafts and non‐vascularized bone fragments, as well as in isolated cultured cells. All cells of the bone are affected, including osteoblasts, osteocytes, osteoclasts, chondrocytes, and bone marrow cells. Critical ischemia times for induction of bone cell death, either in the ischemic period or following reperfusion, are in the range of 3 to 7 h. These critical ischemia times are significantly increased by decreasing the temperature from 37 °C to 0–4 °C. Anoxia is the most likely trigger of cell injury in the ischemic phase. In the reperfusion phase, reactive oxygen species are decisively involved in the injurious process. In general, however, the available information on the mechanism of ischemia‐reperfusion injury of the bone is relatively sparse. On the other hand, there are clear similarities to the mechanisms of ischemia‐reperfusion injury known from other organs, and there is a clear potential for protection against ischemia‐reperfusion injury of the bone. 相似文献
4.
5.
LS Melchers M Apotheker-de Groot JA van der Knaap AS Ponstein MB Sela-Buurlage JF Bol BJ Cornelissen PJ van den Elzen HJ Linthorst 《Canadian Metallurgical Quarterly》1994,5(4):469-480
A novel chitinase gene of tobacco was isolated and characterized by DNA sequence analysis of a genomic clone and a cDNA clone. Comparative sequence analysis of both clones showed an identity of 94%. The proteins encoded by these sequences do not correspond to any of the previously characterized plant chitinases of classes I-IV and are designated as class V chitinases. Comparison of the chitinase class V peptide sequence with sequences in the Swiss Protein databank revealed significant sequence similarity with bacterial exo-chitinases from Bacillus circulans, Serratia marcescens and Streptomyces plicatus. It was demonstrated that class V chitinase gene expression is induced after treatment of tobacco with different forms of stress, like TMV-infection, ethylene treatment, wounding or ultraviolet irradiation. Two related chitinase class V proteins of 41 and 43 kDa were purified from Samsun NN tobacco leaves inoculated with tobacco mosaic virus. The proteins were purified by Chelating Superose chromatography and gel filtration. In vitro assays demonstrated that class V chitinases have endo-chitinase activity and exhibit antifungal activity toward Trichoderma viride and Alternaria radicina. In addition, it was shown that class V chitinase acts synergistically with tobacco class I beta-1,3-glucanase against Fusarium solani germlings. 相似文献
6.
W. F. M. Groot Zevert A. J. A. Winnubst G. S. A. M. Theunissen A. J. Burggraaf 《Journal of Materials Science》1990,25(8):3449-3455
Two wet chemical preparation methods are described for yttria-doped tetragonal zirconia powders. Both methods yield powders with an extremely small crystallite size (8 nm) and a narrow size distribution. The agglomerate and aggregate structure of these powders have been investigated by several techniques. Gel precipitation from an alkoxide solution in water (alkoxide synthesis) results in a ceramic powder with irregular-shaped weak and porous agglomerates, which are built up from dense aggregates with a size of 18 nm. Gel precipitates formed from a metal-chloride solution in ammonia (chloride synthesis) do not contain aggregates. Both types of agglomerate are fractured during isostatic compaction. Hydrolysis and washing under (strong) basic conditions probably decrease the degree of aggregation. The aggregate morphology and structure are key parameters in the microstructure development during sintering of a ceramic. Several characteristics of these powders are compared with those of a commerical one (Toyo Soda TZ3Y). 相似文献
7.
Panjian Li Ilkka Kangasniemi Klaas de Groot Tadashi Kokubo 《Journal of the American Ceramic Society》1994,77(5):1307-1312
Gel-derived titania coating on commercial pure (c.p.) titanium induces hydroxyapatite formation onto its surface from a simulated body fluid (SBF, a metastable calcium phosphate solution). The induced apatite is similar to bone apatite in that it is poorly crystallized, calcium-deficient, and carbonate-containing. Furthermore, the carbonate (CO2–3 ) groups go into the apatite lattice and lie at the positions of PO3–4 and OH– to replace these ionic groups, resembling the (CO2–3 ) groups of bone apatite. Therefore, the apatite induced by the gel-derived titania is said to be bonelike. A chemical stimulation, stemming from abundant hydroxyl groups and negative charges at the surface of the titania gel, is believed to be responsible for the bonelike apatite induction. The potential of bone-bonding is predicted for the gel-derived titania, for it is an efficient bonelike apatite inducer in the SBF. 相似文献
8.
A simulation model for winter wheat growth, crop nitrogen dynamics and soil nitrogen supply was tested against experimental data. When simulations of dry matter production agreed with measurements, nitrogen uptake was simulated accurately. The total amount of soil mineral nitrogen as well as the distribution of mineral nitrogen over the various soil layers were generally simulated well, except for experiments in which fertilizer was applied late in spring. In these experiments, applied nitrogen disappeared because it could not be accounted for by the model. Some explanations for this disappearance are briefly discussed. 相似文献
9.
If, during the operation of a foam application unit, a change in the foam production is introduced, the change in the flow becomes noticeable at the point of application onlyafter a certain response delay time. During the operation of the unit it is necessary to take this response delay into consideration. By varying the flow of foam in the application unit, the mass content of foam in the unit is changed as a result of the changed pressure inside the unit. The response delay has been mathematically derived for the flow of agiven type of foam through pipes, as well as through a foam printing unit as a whole. A deviation in the yield of foam on the substrate can be avoided by considering the respons delay caused by a change in the foam production process. 相似文献
10.
Stéphane J. C. Weusten Luc C. E. M. Murrer Matheus T. de Groot John van der Schaaf 《American Institute of Chemical Engineers》2021,67(6):e17263
This article investigates the effect of inlet shape, entrance length, and turbulence promoters on mass transfer by using 3D-printed electrolyzers. Our results show that the inlet design can promote turbulence and lead to an earlier transition to turbulent flow. The Reynolds number at which the transition occurs can be predicted by the ratio of the cross-sectional area of the inlet to the cross-sectional area of the electrolyzer channel. A longer entrance length results in more laminar behavior and a later transition to turbulent flow. With an entrance length of 550 mm, the inlet design did no longer affect the mass transfer performance significantly. The addition of gyroid type turbulence promoters resulted in a factor of 2 to 4 increase in mass transfer depending on inlet design, entrance length, and the type of promoter. From one configuration to another, there was a minimal variation in pressure drop (<1600 Pa). 相似文献