Observer agreement on interpreting colposcopic images of CIN

The purpose of this work was to study intraobserver and interobserver variation in the interpretation of colposcopic images of cervical intraepithelial neoplasia (CIN). Twenty-three experienced colposcopists were asked to assess colposcopic images presented on slides and to select the biopsy site. Eleven cases were independently interpreted twice with an interval of 2-3 months by all observers. No information about the cytological classification was available. In each case the "majority assessment" was considered as the standard, being "no CIN" in 2 cases, CIN I in 4 cases, CIN II in 3 cases, and CIN III in 2 cases. Intraobserver concordance was 66.7%, the kappa value was 0.54. Interobserver agreement was found to be 52.4 and 51.0% in the first and second sessions, respectively, while the mean kappa values were 0.41 and 0.33, respectively. In selecting the site for biopsy, 77.4% of all observers agreed while the same site was selected in 85.3% of cases by the individual colposcopist in the two sessions. Overall, CIN I and II interpretations revealed lower levels of agreement than no CIN or CIN III interpretations. It is concluded that observer variability in interpreting colposcopic images and selecting the site for biopsy is in the same range as observer variation in other subjective diagnostic tests such as cytology and histopathology. This variation should be taken into account in the colposcopical management of patients with abnormal cytology.     

The nondigestible fat sucrose polyester does not stimulate gallbladder emptying in humans

BACKGROUND: We determined the effect of oral ingestion of sucrose polyester, which was approved as a fat replacer in the United States, on gallbladder motility and on the release of cholecystokinin, the hormone that mediates gallbladder emptying. OBJECTIVE: Our objective was to measure effects of sucrose polyester on gallbladder emptying and cholecystokinin release. DESIGN: Eight healthy volunteers (3 men and 5 women) drank 60 mL sucrose polyester, digestible fat, or saline solution in a balanced crossover design on 3 separate days. RESULTS: Mean (+/-SEM) gallbladder emptying, when integrated over time, was low in response to both sucrose polyester (-150 +/- 214 mL x 120 min) and saline solution (-89 +/- 123 mL x 120 min). In contrast, there was marked emptying in response to digestible fat (1069 +/- 253 mL x 120 min). Sucrose polyester did not affect plasma cholecystokinin concentrations (-9.3 +/- 15.0 pmol x 120 min/L), whereas digestible fat resulted in a significant increase (89.5 +/- 44.8 pmol x 120 min/L, P = 0.014) compared with saline solution (-3.0 +/- 13.8 pmol x 120 min/L). CONCLUSIONS: Ingestion of sucrose polyester, in contrast with digestible fat, did not stimulate gallbladder emptying or release of cholecystokinin.     

Design of an Optical Photon Counting Array Receiver System for Deep-Space Communications

Demand for increased capacity in deep-space to Earth communications systems continues to rise as sensor data rates climb and mission requirements expand. Optical free-space laser communications systems offer the potential for operating at data rates 10 to 1000 times that of current radio-frequency systems. A key element in an optical communications system is the Earth receiver. This paper reviews the design of a distributed photon-counting receiver array composed of four meter-class telescopes, developed as a part of the mars laser communications demonstration (MLCD) project. This design offers a cost-effective and adaptable alternative approach to traditional large, single-aperture receive elements while preserving the expected improvement in data rates enabled by free-space laser communications systems. Key challenges in developing distributed receivers and details of the MLCD design are discussed.     

Digital color imaging colposcopy: a matter of choice

PURPOSE: The objective of this study was to correlate the findings of sarcoidosis on high resolution CT (HRCT) with indexes of disease activity as measured with 67Ga scan, bronchoalveolar lavage (BAL), and serum angiotensin-converting enzyme (SACE) assay. METHOD: Twenty-nine patients with proven sarcoidosis underwent HRCT scan, 67Ga scan, BAL, and SACE assay within a 1 month period. The extent of parenchymal involvement by nodules, consolidation, ground-glass attenuation, and linear opacities was quantified to the nearest 10% of surface area affected on the CT examination. Whole-lung gallium uptake was quantified and the percentage of BAL-recovered lymphocytes (BAL-%LC) and SACE levels obtained by chart review. CT scores of disease extent were correlated with measured indexes of activity using the Spearman rank correlation coefficient. RESULTS: The mean extent of nodules, consolidation, ground-glass attenuation, and linear opacities on HRCT images was 15.1 +/- 16.6, 1.6 +/- 4.0, 17.5 +/- 25.4, and 7.6 +/- 9.6%, respectively. The extent of nodules and consolidation correlated with the intensity of lung gallium uptake (r = 0.46, p < 0.02), BAL-%LC (r = 0.50, p < 0.01), and SACE levels (r = 0.38, p < 0.05). No significant correlation was found between extent of ground-glass attenuation or linear opacities with any indexes of disease activity. CONCLUSION: On HRCT scan, nodules and consolidation in sarcoidosis reflect disease activity as measured by 67Ga scan, BAL, and SACE assay.     

Combining laser chemical processing and aerosol jet printing: a laboratory scale feasibility study

First results showing the viability of combining laser chemical processing (LCP) and aerosol jet printing (AJP) technologies to produce a high‐efficiency front side for silicon solar cells are presented. LCP simultaneously opens the anti‐reflection coating (ARC) and highly dopes the underlying silicon to create a selective emitter, while AJP is the first in a two‐step fine‐line contact formation procedure. The electrical properties as well as the morphology of the resulting structures are presented. Performance similar to that achieved with evaporated TiPdAg metallization is demonstrated. Copyright © 2010 John Wiley & Sons, Ltd.     

Quasi-one-dimensional photonic crystal as a compact building-block for refractometric optical sensors

We report the fabrication and the characterization of the refractometric and thermo-optical properties of a quasi-one-dimensional waveguide photonic crystal-a strong, 76-/spl mu/m-long Bragg grating. The transmission spectra (around 660 nm) of the structure have been measured as a function of both the cladding refractive index and the temperature. The transmission stopband was found to shift by 0.8-nm wavelength for either a cladding refractive index change of 0.05 or a temperature change of 120 K. The steep stopband edges provide a sensitive detection method for this band shift, by monitoring the transmitted output power.     

Study on the edge isolation of industrial silicon solar cells with waterjet-guided laser

In this paper, we review the device physics to explain the necessity of edge isolation as well as the various common methods for performing this important step. In order to assess these processes, different aspects have to be taken into consideration and will be discussed. Finally, experimental results of edge isolation on commercial multicrystalline solar cells with waterjet-guided laser (wavelength 1064 nm) and conventional laser (wavelength 355 nm) are presented and discussed. From the experiments, we conclude that the waterjet-guided laser shows the potential to improve the laser scribing process in terms of pn junction damage and mechanical stability.     

The value of interphase cytogenetics in cytology for the diagnosis of leptomeningeal metastases

We studied the use of fluorescence in situ hybridization (FISH) in CSF to enhance the diagnostic yield for the detection of malignancy on the first lumbar puncture in patients clinically suspected of having leptomeningeal metastases (LMM). Although repeated lumbar punctures were still needed in some patients, the use of FISH did speed up the diagnosis in approximately one-third of the patients clinically suspected of having LMM with atypical cells at first cytology. This eliminates the need for repeated lumbar punctures in these patients and enables an earlier start of treatment.     

Ultrasonic doppler technique for microvascular bypass (author's transl)

Following an operative microvascular extraintracranial bypass, 50 patients were re-examined by the ultrasonic Doppler technique. The findings were compared with the results achieved by post-operative angiography. This examination of the patency of extraintracranial anastomoses with the ultrasonic Doppler technique can be conducted on an outpatient basis, is noninvasive and can be frequently repeated. It has a high degree of accuracy (96%). In addition, there were indications that, in certain areas, a gauge could be established for the function of the anastomosis by comparing the amplitude indices from the bypass and the afferent vessels. Key-words: Ultrasonic Doppler technique - microvascular bypass - cerebral blood flow - cerebrovascular disorders