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1.
Ioanna Roussaki Maria Strimpakou Carsten Pils 《Journal of Network and Systems Management》2007,15(1):57-74
The challenge of saturating all phases of pervasive service provision with context-aware functionality lies in coping with
the complexity of maintaining, retrieving and distributing context information. To efficiently represent and query context
information a sophisticated modelling scheme should exist. To distribute and synchronise context knowledge in various context
repositories across a multitude of administrative domains, streamlined mechanisms are needed. This paper elaborates on an
innovative context management framework that has been designed to cope with free-text and location based context retrieval
and efficient context consistency control. The proposed framework has been incorporated in a multi-functional pervasive services
platform, while most of the mechanisms it employs have been empirically evaluated. 相似文献
2.
This exploratory study took place in the context of middle school information science in Greece, to examine possible relations between boys’ and girls’: value and efficacy beliefs about computers and information science; perceived parental support; perceived teacher expectations; and perceptions of the nature of information science instruction. The participants of the study were 301 (135 male and 166 female) students who responded to a self-report questionnaire. Regression analysis showed that perceived teacher expectations were positively associated with students’ ability beliefs, perceptions of learning activities as creative and personally meaningful was a significant predictor of students’ interest in computing, and perceived parental support was related to both value and efficacy beliefs. Unlike previous research, the findings of this study did not support the conclusion that boys have more positive ICT self-efficacy and value beliefs than girls. They indicated however, that boys’ and girls’ beliefs are differentially affected by parents, teachers, and school IS instruction. 相似文献
3.
Ioanna Lykourentzou Ioannis Giannoukos Vassilis Nikolopoulos George Mpardis Vassili Loumos 《Computers & Education》2009,53(3):950-965
In this paper, a dropout prediction method for e-learning courses, based on three popular machine learning techniques and detailed student data, is proposed. The machine learning techniques used are feed-forward neural networks, support vector machines and probabilistic ensemble simplified fuzzy ARTMAP. Since a single technique may fail to accurately classify some e-learning students, whereas another may succeed, three decision schemes, which combine in different ways the results of the three machine learning techniques, were also tested. The method was examined in terms of overall accuracy, sensitivity and precision and its results were found to be significantly better than those reported in relevant literature. 相似文献
4.
Eleni Koliakou Manthou Maria Eleni Ioanna Koumentakou Nikolaos Bikiaris Polyanthi Konstantinidou Patricia Rousselle Doxakis Anestakis Elisabeth Lazaridou Evangelia Kalloniati Dimosthenis Miliaras Anna Michopoulou 《International journal of molecular sciences》2022,23(12)
Syndecans act as independent co-receptors to exert biological activities and their altered function is associated with many pathophysiological conditions. Here, syndecan-1 and -4 were examined in lesional skin of patients with psoriasis. Immunohistochemical staining confirmed altered syndecan-1 distribution and revealed absence of syndecan-4 expression in the epidermis. Fibronectin (FN)—known to influence inflammation and keratinocyte hyperproliferation via α5β1 integrin in psoriasis—was also decreased. Syndecan-1 and -4 expression was analyzed in freshly isolated lesional psoriatic human keratinocytes (PHK) characterized based on their proliferation and differentiation properties. mRNA levels of syndecan-1 were similar between healthy and PHK, while syndecan-4 was significantly decreased. Cell growth and release of the pro-inflammatory Tumor Necrosis Factor-alpha (TNFα) were selectively and significantly induced in PHKs plated on FN. Results from co-culture of healthy keratinocytes and psoriatic fibroblasts led to the speculation that at least one factor released by fibroblasts down-regulate syndecan-1 expression in PHK plated on FN. To assay if biological treatments for psoriasis target keratinocyte proliferation, gelatin-based patches enriched with inteleukin (IL)-17α or TNFα blockers were prepared and tested using a full-thickness healthy epidermal model (Phenion®). Immunohistochemistry analysis showed that both blockers impacted the localisation of syndecan-1 within the refined epidermis. These results provide evidence that syndecans expression are modified in psoriasis, suggesting that they may represent markers of interest in this pathology. 相似文献
5.
Ioanna Nikitopoulou Aggeliki Katsifa Paraskevi Kanellopoulou Edison Jahaj Alice G. Vassiliou Zafeiria Mastora Ioanna Dimopoulou Stylianos E. Orfanos Vassilis Aidinis Anastasia Kotanidou 《International journal of molecular sciences》2022,23(14)
The pathogenesis of sepsis involves complex interactions and a systemic inflammatory response leading eventually to multiorgan failure. Autotaxin (ATX, ENPP2) is a secreted glycoprotein largely responsible for the extracellular production of lysophosphatidic acid (LPA), which exerts multiple effects in almost all cell types through its at least six G-protein-coupled LPA receptors (LPARs). Here, we investigated a possible role of the ATX/LPA axis in sepsis in an animal model of endotoxemia as well as in septic patients. Mice with 50% reduced serum ATX levels showed improved survival upon lipopolysaccharide (LPS) stimulation compared to their littermate controls. Similarly, mice bearing the inducible inactivation of ATX and presenting with >70% decreased ATX levels were even more protected against LPS-induced endotoxemia; however, no significant effects were observed upon the chronic and systemic transgenic overexpression of ATX. Moreover, the genetic deletion of LPA receptors 1 and 2 did not significantly affect the severity of the modelled disease, suggesting that alternative receptors may mediate LPA effects upon sepsis. In translation, ATX levels were found to be elevated in the sera of critically ill patients with sepsis in comparison with their baseline levels upon ICU admission. Therefore, the results indicate a role for ATX in LPS-induced sepsis and suggest possible therapeutic benefits of pharmacologically targeting ATX in severe, systemic inflammatory disorders. 相似文献
6.
Afroditi Kastrenopoulou Kyriakos E. Kypreos Nicholaos I. Papachristou Stavros Georgopoulos Ioulia Mastora Ioanna Papadimitriou-Olivgeri Argyro Spentzopoulou Dragana Nikitovic Vassilios Kontogeorgakos Harry C. Blair Dionysios J. Papachristou 《International journal of molecular sciences》2022,23(9)
In the present study, we studied the effect of apolipoprotein A-1 (APOA1) on the spatial and molecular characteristics of bone marrow adipocytes, using well-characterized ApoA1 knockout mice. APOA1 is a central regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, and thus HDL; our recent work showed that deficiency of APOA1 increases bone marrow adiposity in mice. We found that ApoA1 deficient mice have greatly elevated adipocytes within their bone marrow compared to wild type counterparts. Morphologically, the increased adipocytes were similar to white adipocytes, and displayed proximal tibial-end localization. Marrow adipocytes from wild type mice were significantly fewer and did not display a bone-end distribution pattern. The mRNA levels of the brown/beige adipocyte-specific markers Ucp1, Dio2, Pat2, and Pgc1a; and the expression of leptin were greatly reduced in the ApoA1 knock-out in comparison to the wild-type mice. In the knock-out mice, adiponectin was remarkably elevated. In keeping with the close ties of hematopoietic stem cells and marrow adipocytes, using flow cytometry we found that the elevated adiposity in the ApoA1 knockout mice is associated with a significant reduction in the compartments of hematopoietic stem cells and common myeloid, but not of the common lymphoid, progenitors. Moreover, the ‘beiging’-related marker osteopontin and the angiogenic factor VEGF were also reduced in the ApoA1 knock-out mice, further supporting the notion that APOA1—and most probably HDL-C—regulate bone marrow microenvironment, favoring beige/brown adipocyte characteristics. 相似文献
7.
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9.
Ioanna Diamandi John N. Sahalos Elias Vafiadis 《International Journal of Numerical Modelling》1993,6(2):99-108
A rigorous formulation of the scattering by a magnetized ferrite in a rectangular waveguide is presented. The EM field depends on the dimension, the frequency and the internal static magnetic field of the ferrite post. For some special values of the above quantitites the reflection or the transmission coefficient becomes equal to zero. These values give a family of filters and the results which follow explain their characteristics. 相似文献
10.
摘译 近年来,作为一种高能量带隙半导体,二氧化钛(TiO2)由于在紫外光照射下具有良好的光催化活性,已引起科研人员的广泛关注.由于TiO2无色透明,具有广泛的应用前景,如薄的TiO2涂层可用于创建自清洁、防雾、超亲水表面.同时,也能用于太阳能电池等光电子行业.
化学溶液沉积法因具有相对简单的大面积生产工艺,且较低的制膜成本和高可用性,成为TiO2薄膜制备常用的方法之一.针对另一种TiO2制备方法,即溶胶凝胶法,大量研究文献主要关注乙醇的水解控制.然而,工业需求鼓励开发水基前驱设计.其难度在于钛醇盐与水的高反应性.在有机介质中,加入少量的水往往导致水解.因此,需要采用络合剂作为稳定剂,阻止纯水中的水解反应和避免由此产生的产物沉淀. 相似文献