Une méthode d’optimisation discrète pour les filtres cascade à capacités commutées

A discrete optimization method using a noninteraction property between the different sections of cascade switched-capacitor filter is described. The optimization, realized with a reduced set of intermediate parameters caracterizing each section, yields to a non minimum capacitive area structure, but which has very accurate capacitor ratios and which could be realized with minimum unit capacitors. This method may be applied to switched-current filters (aspect ratios of transistor discretization). An eighth order band-pass Cauer filter and a fifth order low-pass Cauer filter show the effectiveness of this method.     

Engineering Sensor Arrays Using Aggregation‐Induced Emission Luminogens for Pathogen Identification

Lacking rapid and reliable pathogen diagnostic platforms, inadequate or delayed antimicrobial therapy could be made, which greatly threatens human life and accelerates the emergence of antibiotic‐resistant pathogens. In this contribution, a series of simple and reliable sensor arrays based on tetraphenylethylene (TPE) derivatives are successfully developed for detection and discrimination of pathogens. Each sensor array consists of three TPE‐based aggregation‐induced emission luminogens (AIEgens) that bear cationic ammonium group and different hydrophobic substitutions, providing tunable logP (n‐octanol/water partition coefficient) values to enable the different multivalent interactions with pathogens. On the basis of the distinctive fluorescence response produced by the diverse interaction of AIEgens with pathogens, these sensor arrays can identify different kinds of pathogens, even normal and drug‐resistant bacteria, with nearly 100% accuracy. Furthermore, blends of pathogens can also be identified accurately. The sensor arrays exhibit rapid response (about 0.5 h), high‐throughput, and easy‐to‐operate without washing steps.     

系统级封装技术及其应用

本文介绍了系统级封装技术及其兴起背景,对比了与SoC的异同。通过分析系统级封装的技术特点,阐述了其优势;分析了系统级封装的成本构成和特点。本文从集成电路产业链整合的观点,分析了国内系统级封装的机遇与挑战;以长电科技为例,介绍了系统级封装在设计、制造上的关键技术与当前的能力,并分析了未来的趋势和挑战。本丈还对当前的系统级封装产品与应用领域做了详细介绍。     

Nanometer scale patterning by scanning tunelling microscope assisted chemical vapour deposition

Single electron devices are of great interest for their possible replacement of transistors in memories. The key to the preparation of these components is the production of low capacitance dots, which requires a lithography step at nanometric scale. Direct patterning of metallic features at nanometric scale is possible by local decomposition of gaseous molecules under a scanning tunneling microscope (STM) tip, by application of a voltage of a few volts on the sample (STM assisted chemical vapour deposition). The gaseous molecules are dissociated by the high electric field (about 10⁷ V/cm) within the tip–sample gap. Rhodium lines and dots have been deposited on gold or silicon surfaces by decomposition of [Rh(PF₃)₂Cl]₂. The influence of the sample voltage was studied and the resolution limit of the technique was investigated.     

Facile Synthesis of Red/NIR AIE Luminogens with Simple Structures,Bright Emissions,and High Photostabilities,and Their Applications for Specific Imaging of Lipid Droplets and Image‐Guided Photodynamic Therapy

Red/near‐infrared (NIR) fluorescent molecules with aggregation‐induced emission (AIE) characteristics are of great interest in bioimaging and therapeutic applications. However, their complicated synthetic approaches remain the major barrier to implementing these applications. Herein, a one‐pot synthetic strategy to prepare a series of red/NIR‐emissive AIE luminogens (AIEgens) by fine‐tuning their molecular structures and substituents is reported. The obtained AIEgens possess simple structures, good solubilities, large Stokes shifts, and bright emissions, which enable their applications toward in vitro and in vivo imaging without any pre‐encapsulation or ‐modification steps. Excellent targeting specificities to lipid droplets (LDs), remarkable photostabilities, high brightness, and low working concentrations in cell imaging application make them remarkably impressive and superior to commercially available LD‐specific dyes. Interestingly, these AIEgens can efficiently generate reactive oxygen species upon visible light irradiation, endowing their effective application for photodynamic ablation of cancer cells. This study, thus, not only demonstrates a facile synthesis of red/NIR AIEgens for dual applications in simultaneous imaging and therapy, but also offers an ideal architecture for the construction of AIEgens with long emission wavelengths.     

Analysis of the Double Laser Emission Occurring in 1.55-μm InAs–InP (113)B Quantum-Dot Lasers

In this paper, a theoretical model based on rate equations is used to investigate static and dynamic behaviors of InAs-InP (113)B quantum-dot (QD) lasers emitting at 1.55 mum. More particularly, it is shown that two modelling approaches are required to explain the origin of the double laser emission occurring in QD lasers grown on both, GaAs and InP substrates. Numerical results are compared to experimental ones by using either a cascade or a direct relaxation channel model. The comparison demonstrates that when a direct relaxation channel is taken into account, the numerical results match very well the experimental ones and lead to a qualitative understanding of InAs-InP (113)B QD lasers. Numerical calculations for the turn-on delay are also presented. A relaxation oscillation frequency as high as 10 GHz is predicted which is very promising for the realization of directly modulated QD lasers for high-speed transmissions.     

A Substitution‐Dependent Light‐Up Fluorescence Probe for Selectively Detecting Fe3+ Ions and Its Cell Imaging Application

Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position‐dependent substituent effects, an aggregation‐induced emission featured iron (III) probe from ortho‐substituted pyridinyl‐functionalized tetraphenylethylene (TPE‐o‐Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho‐substitution, and the fact that TPE‐o‐Py has a low acid dissociation constant (pK _a) that is close to that of hydrolyzed Fe³⁺. Importantly, TPE‐o‐Py as a light‐up fluorescence probe could be employed for Fe³⁺ sensing in living cells with a pronounced red‐shift in fluorescence emission.     

Tailoring the Molecular Properties with Isomerism Effect of AIEgens

It is challenging to achieve precise control on the properties of organic π‐functional materials to widen their practical applications. On the other hand, the study of aggregation‐induced emission luminogens (AIEgens) helps achieve such goals because of inherent relationships between their luminescence behaviors and conformational variations that allow for the visual monitoring of the changes in the material properties. Inspired by this, in this work, three AIE isomers are fabricated in structures consisting of tetraphenylpyrazine and triphenylethene units with para‐, meta‐, and ortho‐position linkages, respectively. The isomerism effect brings about significantly decreased luminescence efficiency, subtly blueshifted emission, basically reduced AIE effect but boosted porosity in the aggregate state as the conformation of AIEgens evolves from an extended to a folded one. Based on the distinct properties, their respective use in blue organic light‐emitting diodes, nanofluorescent probes, and molecule‐capturing porous crystals are investigated. This work not only achieves precise property control by using the isomerism effect of AIEgens but also provides useful information on the future design of π‐conjugated materials with advanced functionalities.     

Automatic quantification of changes in bone in serial MR images of joints

Recent innovations in drug therapies have made it highly desirable to obtain sensitive biomarkers of disease progression that can be used to quantify the performance of candidate disease modifying drugs. In order to measure potential image-based biomarkers of disease progression in an experimental model of rheumatoid arthritis (RA), we present two different methods to automatically quantify changes in a bone in in-vivo serial magnetic resonance (MR) images from the model. Both methods are based on rigid and nonrigid image registration to perform the analysis. The first method uses segmentation propagation to delineate a bone from the serial MR images giving a global measure of temporal changes in bone volume. The second method uses rigid body registration to determine intensity change within a bone, and then maps these into a reference coordinate system using nonrigid registration. This gives a local measure of temporal changes in bone lesion volume. We detected significant temporal changes in local bone lesion volume in five out of eight identified candidate bone lesion regions, and significant difference in local bone lesion volume between male and female subjects in three out of eight candidate bone lesion regions. But the global bone volume was found to be fluctuating over time. Finally, we compare our findings with histology of the subjects and the manual segmentation of bone lesions.