Cointegration of Gate-All-Around MOSFETs and Local Silicon-on-Insulator Optical Waveguides on Bulk Silicon

In this work we present a bulk silicon technology platform able to cointegrate gate-all-around (GAA) MOSFETs and local SOI waveguides with pentagonal cross section. Wire diagonals of 100-800 nm are obtained using a lithographic resolution of 0.8 mum. Well-functioning triangular multigate MOSFETs are reported, and tested up to 150 degC. A significant increase is observed in the low-field mobility mu₀ for small devices (W_effles500 nm), which is attributed to local volume inversion in the corners. Preliminary characterization of the optical waveguides is carried out, showing optical losses of a few dB/cm. The processing is entirely CMOS compatible, does not require access to advanced lithography equipment, and is based on a silicon bulk substrate. Thus, this technology might serve as the basis for a low-cost, high-performance optical signaling platform     

Entangled Cross-Linked Fibres for an Application as Core Material for Sandwich Structures - Part I: Experimental Investigation

Entangled cross-linked fibres were studied for an application as core material for sandwich structures. Specimens were produced from carbon, aramid and glass fibres, and cross-links were achieved using epoxy spraying. It was observed that this type of entangled cross-linked fibres could be fabricated without any major technical difficulties. The scope of this paper is to study the effect of some different parameters on the mechanical properties of these materials. Different effects were investigated: effect of fibres length, of fibres nature, of mixing fibres, of carbon skins and of the resin. The first part of this paper deals with the production of these entangled cross-linked fibres. The compression, tension and three point bending tests are detailed in the second part and the results are compared with usual core material currently used in industries.     

Mechanical behavior of entangled fibers and entangled cross-linked fibers during compression

Entangled fibrous materials have been manufactured from different fibers: metallic fibers, glass fibers, and carbon fibers. Specimens have been produced with and without cross-links between fibers. Cross-links have been achieved using epoxy spraying. The scope of this article is to analyze the mechanical behavior of these materials and to compare it with available models. The first part of this article deals with entangled fibrous materials without cross-link between fibers. Compression tests are detailed and test reproducibility is checked. In the second part, compression tests were performed on materials manufactured with cross-linked fibers. The specific mechanical behavior obtained is discussed.     

The mini-conical slump flow test: Analysis and numerical study

This paper provides a general study on cement paste flow. Both mini-slump and Marsh cone tests are used to evaluate the workability of fresh paste mixtures derived from self compacting concretes. A numerical approach is used to reproduce global flow behavior and to check the accuracy of the obtained viscosity as well as the validity of expressions available in the literature giving yield stress from the final diameter of slumped paste. The computational modeling allows access to local information in order to analyze different regions and corresponding flow types, i.e. falling solid and flowing fresh cementing material mixtures.The limitation of some empirical models allowing the prediction of yield stress τ₀ and plastic viscosity μ from mini-slump tests is underlined, conditions of validity are expressed and a new expression is proposed.     

Fatigue crack growth in thin notched woven glass composites under tensile loading. Part I: Experimental

Helicopter blades are made of composite materials mainly loaded in fatigue and have normally relatively thin skins. A through-the-thickness crack could appear in these skins. The aim of this study is to characterize the through-the-thickness crack propagation due to fatigue in thin woven glass fabric laminates. A technological test specimen is developed to get closer to the real loading conditions acting on these structures. An experimental campaign is undertaken which allows evaluating crack growth rates in several laminates. The crack path is linked through microscopic investigations to specify damage in woven plies. Crack initiation duration influence on experimental results is also underlined.     

Tuberculosis. Current therapeutics

Due to the constant decline in incidence up to the mid eighties, eradication of tuberculosis appeared to be an attainable objective in developed countries. Since then multiple factors (HIV epidemic, poor social conditions in certain unfavored areas, population migrations, urbanization) have led to an increased frequency, making an excellent knowledge of tuberculosis a priority for all physicians. Multi-resistant mycobacteria have also made their appearance leading to numerous clinical and experimental studies which provide new insights into the correct management of patients with tuberculosis. Despite these recent changes, the classical treatment for tuberculosis remains the same in most cases, allowing nearly-certain cure when applied correctly in patients infected with a susceptible bacteria, including those with HIV infection or extrapulmonary localizations. On the contrary, the spontaneous aggravation of multi-resistant tuberculosis, even in some cases being treated, emphasizes the need to test the strain's susceptibility to the antituberculous agents used. Certain new antibiotics, including fluoroquinolones, may play an important role in some cases. The contribution of surgery, isolation and strict compliance must also be emphasized. Resistant strains may also led to renewed indications for the Calmette-Guérin vaccine.     

A packaging system for SV40 vectors without viral coding sequences

We studied the incidence of regurgitation in 100 patients undergoing elective gynecological laparoscopies under general anesthesia with intermittent positive pressure ventilation using a laryngeal mask airway (LMA). Patients ingested methylene blue capsules 10-15 min before induction of anesthesia. After induction and insertion of an LMA using the recommended insertion technique, a fiberoptic examination of the larynx was made for traces of dye and to site a pH probe in the bowl of the LMA for continuous monitoring. LMA insertion was successful in all patients within two attempts (95 at first attempt). Fiberoptic examination revealed the vocal cords or cords and posterior or anterior epiglottis in 96 and no trace of dye in 99 patients. One patient regurgitated dye immediately after induction, and the stain was seen on the LMA after removal. The remaining 99 LMAs were not stained. Thirty patients were randomly selected for fiberoptic examination of the laryngopharynx before neuromuscular block was antagonized. Methylene blue staining did not occur in any of these patients. In 91 patients with complete pH data, regurgitation (pH < 4.0) did not occur. The 95% confidence limit for a true probability of regurgitation in this study is 0.041 or a true rate of regurgitation of less than 4.1%. A larger study would be required to possibly demonstrate a lower incidence of regurgitation. This study confirms the clinical impression that the incidence of regurgitation during laparoscopies with a LMA is extremely low.     

An endogenous sialoprotein and a bacterial B cell superantigen compete in their VH family-specific binding interactions with human Igs

Staphylococcal protein A (SpA), a bacterial membrane protein, and protein Fv (Fv binding protein (pFv)), a human sialoprotein involved in gut-associated immunity, have both recently been shown to have unconventional V(H) family-restricted binding interactions with Igs. To determine whether these Ig binding proteins interact with related structures, we performed a series of comparative binding studies. The results confirmed that both molecules are bound by most V(H)3 IgM, but pFv is also recognized by V(H)3 and V(H)6 Ig that do not interact with SpA. We discovered that pFv and SpA (or a single domain of SpA) can compete for binding to a V(H)3 Ab, which suggests that they can recognize the same (or adjacent) V(H) sites. For both SpA and pFv, binding is less frequent among IgG than IgM. However, V(H)3 IgG more commonly possess Fab-mediated binding activity for pFv than for SpA. Binding studies of denatured Ig suggested that both pFv and SpA interact with conformationally dependent V(H) sites, although in certain cases pFv binding is more permissive than SpA binding. Taken together, these results indicate that the superantigen properties of SpA, a microbial protein, and those of pFv, an endogenous sialoprotein, involve binding interactions with overlapping and at times functionally equivalent sites in the V(H) domain, indicating that self and foreign proteins can employ highly conserved strategies to create superantigens for the Ag receptors of B lymphocytes.     

Détection d’un signal déterministe après réflexions aléatoires

In active signal detection (e.g., radar, sonar, geophysics, etc.), the objective is to extract in the presence of background noise a signal which is known at the transmission but randomly reflected by the target. The received signal is, therefore, no longer deterministic, and the optimum receiver is not a simple matched filter even if the noise is white Gaussian. By introducing appropriate probability distributions for the random reflection, the authors make a mathematical model of the received signal and calculate the likelihood ratio for the Gaussiannoise case. The optimum receiver consists of the matched filter followed by a nonlinear device, which can be represented by a series of filters, and a time-integrator. In a special case of impulse-like signals, the nonlinearity is virtually memoryless. In the case of low signal-to-noise ratio, the series can be approximated by the first two terms, namely, the linear and the quadratic filters.