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1.
Lili Chen Nanami Fujisawa Masato Takanohashi Mazaya Najmina Koichiro Uto Mitsuhiro Ebara 《International journal of molecular sciences》2021,22(5)
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery. 相似文献
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3.
Koichiro Kato 《应用聚合物科学杂志》1975,19(4):951-957
Polyethylene films were irradiated in air by ultraviolet light. 2,4-Dinitrophenylhydrazine was reacted on the irradiated films. The changes in amounts of carbonyl groups and 2,4-dinitrophenynlhydrazones formed in the films were inferred by comparing their absorptions in the infrared and ultraviolet spectra, respectively. It seems that the contents of carbonyl groups formed in the amorphous regions in the high-density polyethylene films by the irradiation were larger than the contents of carbonyl groups formed in the amorphous regions in the low-density polyethylene films. The decreases in contact angles of water on the high-density polyethylene films by the irradiation were larger than the decreases in the contact angles on the low-density polyethylene films. The amounts of 2,4-dinitrophenylhydrazones formed in the irradiated high-density polyethylene films were less than the amounts of 2,4-dinitrophenylhydrazones formed in the irradiated low-density polyethylene films. 相似文献
4.
In the theory of shape from shading, behaviours of the local solution around a critical point of the image play an important role. This paper shows that the second derivatives of the object surface can be locally determined at these image critical points. Closed form expressions of the surface second derivatives in terms of the second derivatives of the image brightness and of the reflectance map are shown. They are derived as follows: By differentiating the image irradiance equation twice at an image critical point, a set of polynomial equations is obtained that contains the second derivatives of the surface, of the image brightness and of the reflectance map. Regarding these equations as simultaneous equations for unknown surface second derivatives, they are algebraically solved and their explicit expressions are derived. Such a derivation is possible only at image critical points and is impossible at any other image point. The applicability of the derived expressions to noisy images is tested using synthetic images. 相似文献
5.
Koichiro Hirano Masafumi Fukuda Mikio Takano Yoshio Yamazaki Toshiya Muto Sakae Araki Nobuhiro Terunuma Masao Kuriki Mitsuo Akemoto Hitoshi Hayano Junji Urakawa 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2006,560(2):233-239
A multi-bunch photo-cathode RF gun system has been developed as an electron source for the production of intense quasi-monochromatic X-rays based on inverse Compton scattering. The desired multi-bunch beam is 100 bunches/pulse with a total charge of 500 nC and a bunch spacing of 2.8 ns. We modified the gun cavity of a ‘BNL-type IV’ RF gun to allow a CsTe cathode plug in the end plate. The system uses a four-dipole chicane beam line to allow the injection of laser light normal to the cathode surface. We compensate the gun cavity beam loading caused by the high-intensity multi-bunch electron beam by injecting the laser pulse before RF power has filled the cavity. We have achieved a total intensity of 220 nC in 100 bunches with a bunch-to-bunch energy spread under 1.3% (peak-to-peak). This paper concentrates on experiments to generate the high-intensity multi-bunch beam with compensation of the bunch-to-bunch energy spread due to heavy beam loading. 相似文献
6.
Toru Moriyama Jun-ichi Mashiko Toshinori Matsui Koichiro Enomoto Tetsuya Matsui Kojiro Iizuka Masashi Toda Yukio Pegio Gunji 《Artificial Life and Robotics》2016,21(3):247-252
The soldier crab appears in great numbers and feeds while wandering during daytime low tide. When they see an approaching object, they screw themselves into the sand. The mechanism of formation of mass wandering has not been clarified. In this study, to investigate if the soldier crabs use visual images of neighbors as a stimulus for wandering, dummy crabs were presented to crabs. In the experiments, one, two, four, or eight dummies were placed in a circle on a sand arena. Each crab was placed in the center of the arena and observed whether it burrowed into the sand or wandered. The proportions of wandering individuals in each experimental treatment were compared with the expected value. Significantly more crabs were wanderers when only two and four dummies were present. This result suggests that soldier crabs chose burrowing or wandering depending on visual image of the distribution of the neighbors. 相似文献
7.
Toshinori Nakagawa Qinchang Zhu Hiroya Ishikawa Koichiro Ohnuki Kenichi Kakino Naoya Horiuchi 《木材化学与工艺学杂志》2016,36(1):42-55
This article presents multiple potential uses of the Yakushima native cedar (Cryptomeria japonica), known in Japan as the Yaku-sugi tree. The Yaku-sugi was divided into four parts: leaves, branches with leaves, branches, and stems. We obtained the essential oil, hydrosol, distillation residue, and distillation wastewater from the trees. Essential oil and hydrosol were determined to be volatile organic compounds. All samples were screened for the following bioactivities: antioxidative, antibacterial, and anti-melanogenesis activities. Freeze-dried distillation residue was tested to assess whether it had a deodorizing effect. The main component of the leaf essential oil was found to be monoterpenes. In contrast, the stem essential oil mainly contained sesquiterpenes. In terms of bioactivities, the leaf essential oil showed antibacterial activity and the stem essential oil showed anti-melanogenesis activity. Distillation residue and wastewater showed many activities, including antioxidant, antibacterial, and anti-melanogenesis activities. Moreover, the residue had a deodorizing effect against ammonia. 相似文献
8.
The objective of this study is to evaluate simultaneously the time dependence of the thermal diffusivity of carbon-carbon composites (C/C composites) and their porosity during heat treatment using the electromagnetic ultrasonic technique. This paper describes two kinds of experiments conducted to confirm the principle for simultaneous measurement of both the ultrasonic velocity (used to evaluate the porosity) and the thermal diffusivity at room temperature. For each material, the samples used in both experiments were identical. The ultrasonic velocity of type 304 stainless steel and its thermal diffusivity were 5.85 km/s and 3.8 mm2/s with precisions of ±1.6 and ±8 percent, respectively. The ultrasonic velocity of a two-dimensional woven C/C composite and its thermal diffusivity were 2.86 km/s and 4.8 mm2/s with precisions of ±5.0 and ±8 percent, respectively. The results appear to indicate that the electromagnetic ultrasonic technique can measure the ultrasonic velocity and the thermal diffusivity simultaneously and that it is also applicable to C/C composites. © 1997 Scripta Technica, Inc. Heat Trans Jpn Res, 25(5): 308–322, 1996 相似文献
9.
Fumihide Shiraishi Koei Kawakami Hiroshi Marushima Koichiro Kusunoki 《Starch - St?rke》1989,41(11):417-420
Effects of aliphatic alcohols such as ethanol, n-butanol and n-decanol on the formation of cyclodextrin (CD) from soluble starch by Bacillus macerans cyclodextrin glucanotransferase (CGTase) were experimentally studied at 50°C and pH 6.0. The addition of such aliphatic alcohols caused an increase in α-CD yield, which extent was remarkable in n-butanol. From the incubation of α-CD with CGTase, such an increase was found to be due to a restriction on further transglycosylation of α-CD into β-CD by CGTase imposed by the aliphatic alcohols. 相似文献
10.
Isao Mochida Yozo Korai Hiroshi Fujitsu Kenjiro Takeshita Koichiro Mukai Wataru Migitaka Yoshio Suetsugu 《Fuel》1981,60(5):405-412
Carbonization properties of a Ql-free coal-tar pitch (CTP-ASM) prepared by selective precipitation were studied to evaluate it as a source for needle-coke. Its modifying ability for production of needlecoke in co-carbonizations with principal carbonizing substances which gave cokes of mozaic texture in single carbonizations was estimated by changing mixing ratios. The shape and size of the anisotropic optical texture in the co-carbonized coke were measured by point counting. CTP-ASM and Ashland A240, of eight additives, had the highest modifying ability in the co-carbonizations with Khafji vacuum residue. Both contained ca. 6% benzene-insolubles (Bl), and had fa values of ≈0.9. Other additives of either lower or higher Bl or fa showed less modifying ability. The modifying susceptibility of principal carbonizing substances varies with their structure and properties. Based on a systematic investigation of co-carbonizations the compatibility between a principal carbonizing substance and an additive is discussed from a viewpoint of their structural parameters. 相似文献