Prestressed concrete containment of nuclear power station with PWR

The initial steps of the development of prestressed concrete containment (PCC) for nuclear power plant (NPP) with pressurized water reactors (PWR) in the former USSR are analyzed. The constructive and technological decisions, accepted for primary PCC of Novovoronez NPP, such as the positioning of reinforcement elements and seaths in cylindrical wall and dome of the containment, the anchorage of reinforcement element ends, the technological aspects of concrete works, system and technology of a high level of biaxial pressing on a thin-wall structure at large wrapping angles of power reinforcing strands and etc. are observed. Experience won through the construction and operation of the primary PCC served as a basis for development of a new generation of improved unified PCC (IUPCC) for serial NPP, equipped with PWR of capacity of 1000 MW. The IUPCC is actually a cylinder 45 m in diameter and 54-m high covered with a gently sloping spherical dome. Thickness of cylinder wall is 1200 mm and that of dome wall is 1100 mm. The principle novelty of this PCC is the type and positioning of reinforcement strands. The paper describes strand arrangement and their anchorage in IUPCC. In the vertical part of PCC, strands are arranged on a helical-loop scheme and both strand ends are firmly anchored at the ring girder. Each strand is bended at the bottom of the containment. In the dome, strands are grouped on the orthogonal-loop scheme with the anchorage on one side and with bend of loop on the opposite side of the ring girder. To prevent the leakage of gases and to ensure tightness of the IUPCC an inner metal 8-mm liner with special anti-corrosion coating is designed. Monitoring and checking the stress and strain state of IUPCC is possible during the building, testing as well as operating periods. If any defects or decreased prestress of concrete are detected it is possible to tighten or replace the strands. It is noted that the more than 20 IUPCCs are in-service in Russia, Ukraine, and Bulgaria where NPP with PWR of capacity of 1000 MW were constructed.     

Molecular follow-up of disease progression and interferon therapy in chronic myelocytic leukemia

We previously reported that the abl promoter (Pa) undergoes de novo DNA methylation in the course of chronic myelocytic leukemia (CML). The clinical implications of this finding are the subject of the present study in which samples of CML patients, including a group treated with interferon alpha (IFNalpha) were surveyed. The methylation status of the abl promoter was monitored by polymerase chain reaction (PCR) amplification of the Pa region after digestion with several site-methylation sensitive restriction enzymes. Some 74% of the DNA samples from blood and marrow drawn in the chronic phase were nonmethylated, similar to control samples from non-CML patients. The remaining 26% were partially methylated in the abl Pa region. The latter samples were derived from patients who were indistinguishable from the others on the basis of clinical presentation. Methylated samples were mostly derived from patients known to have a disease of longer duration (26 months v 7.5 months, P = .01). Samples of 30 IFNalpha-treated patients were sequentially analyzed in the course of treatment. Fifteen patients with no evidence of Pa methylation before treatment remained methylation-free. The remainder, who displayed Pa methylation before treatment, reverted to the methylation-free status. The outcome is attributed to IFNalpha therapy, as the Pa methylation status was not reversed in any of the patients treated with hydroxyurea. Methylation of the abl promoter indicates a disease of long-standing, most likely associated with a higher probability of imminent blastic transformation. It appears to predict the outcome of IFNalpha therapy far better than the cytogenetic response.     

The CODATA/IUIS Hybridoma Data Bank: development of a hybrid system to handle complex data relationships

System design for the Hybridoma Data Bank, a database of comprehensive information on immunoreagents for use by scientists in diverse disciplines, is described. Unique problems include: use of nomenclature from diverse fields that is neither static nor standard; the need for two representations of the database--textual for readability and numeric for complex search capabilities, analysis and data compression; and a method of translating between the two representations of the database.     

Letter to the editor

The maximal-cut problem for directed graphs can be defined analogously to that for the undirected case. The undirected problem is known to be NP-complete. We consider two directed variants of the problem. Depending on the definition of the value of a cut, the resulting problem for general directed graphs is either efficiently solvable or NP-complete. We show that the latter version of the problem remains NP-complete when restricted to acyclic directed graphs. Further restriction to directed trees yields an efficiently solvable problem. We present an algorithm solving the problem in time proportional to the size of the input.     

Rain rate statistics and fade distributions at 20 and 30 GHzderived from a network of rain gauges in the mid-Atlantic coast over afive year period

The authors examine five years of rain rate and modeled slant path attenuation distributions at 20 and 30 GHz derived from a network of ten tipping bucket rain gauges located on the mid-Atlantic coast of the US in the vicinity of Wallops Island, VA. Distributions are derived from the variable integration time data from 1-min averages or rain rate time series. It is demonstrated that for realistic fade margins at 20 GHz and above, the variable integration time results are adequate to estimate slant path attenuations using models which require 1-min averages. An accurate empirical formula is developed to convert the variable integration time rain rates to 1-min averages. Rain rate and fade distributions corresponding to the overall network average, yearly network average, and site distributions averaged over the five-year period are derived. Significant differences in the distributions are noted for the year-to-year (temporal variability) and the worst year site-to-site (spatial variability) cases     

Immunological detection of membrane-associated human luteinizing hormone correlates with gene expression in cultured human cancer and fetal cells

We have demonstrated the expression of membrane-associated hCG and its subunits and fragments by cells from 78 human cancer cell lines of different types and origins, indicating that such expression is a common phenotypic characteristic of cultured human malignant cells. Because human (h) LH beta has 80% homology with hCG beta and is coded by one of the seven genes in the gene cluster located in chromosome 19, it was important to determine whether hLH and its beta-subunit are also expressed as membrane-associated proteins by cells from human cancer cell lines. Thus, 11 cancer cell lines of different types and origins were adapted to grow in serumless medium, with Nutridoma-HU or SP as serum substitute, and analyzed by flow cytometry using two monoclonal antibodies directed to different conformational epitopes of intact hLH and a monoclonal antibody reacting with an epitope of hLH beta-free. The cells were also analyzed simultaneously for the expression of hCG and its subunits and fragments. Determination of translatable levels of hLH beta and hCG beta messenger RNAs (mRNAs) was performed in cells from some of the cancer cell lines, including the JEG-3 choriocarcinoma cell line, and in cells from a human fetal lung cell line. The analytical flow cytometry studies showed that in addition to the expression of membrane-associated hCG in all of its forms, expression of membrane-associated intact (holo) hLH and its free beta-subunit occurred in every case. These findings were corroborated by the presence of translatable levels of hLH beta and hCG beta mRNAs in all of the cancer cell lines analyzed, indicating that the expression of these membrane-associated glycoproteins is a phenotypic characteristic of human cancer cells and that the activation of the hCG beta-hLH beta gene cluster is nonselective. The presence of translatable levels of hCG beta-hLH beta mRNAs in the cultured human fetal lung cells punctuates once more the in vivo and in vitro biochemical similarities between fetal and cancer cells.     

Analysis of the exudate produced by Streptococcus mutans SL-1 colonies of sucrose-containing agar media

The watery exudate produced by Streptococcus mutans SL-1 colonies on sucrose-containing agar media was found to contain about 7% (wt/vol) of a water-soluble, branched dextran, 4% sucrose, and smaller (less than 1%) amounts of fructose, Folin-phenol-positive material, and lactic acid.     

Voltage-controlled ferroelectric lens phased arrays

A new concept for phased arrays is proposed using a voltage-controlled ferroelectric lens. The ferroelectric lens concept uniquely incorporates bulk phase shifting-the array does not contain individual phase shifters-using ferroelectric material. This will reduce the number of phase shifters from (n×m) to (n+m), where n is the number of columns and m is the number of rows in a phased array. The number of phase shifter drivers and phase shifter controls is also significantly reduced by using row-column beam steering. Thus, the ferroelectric lens concept can potentially lead to low-cost phased arrays. This paper presents the ferroelectric lens concept, theoretical analysis and design, and experimental results. The results indicate that the ferroelectric lens concept is viable and sound. Various phased-array configurations using ferroelectric lens are included. A discussion on ferroelectric materials is included along with information on a US Department of Defense program to improve ferroelectric materials