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排序方式: 共有79条查询结果,搜索用时 15 毫秒
1.
T Ohishi M Takahashi K Kushida H Hoshino T Tsuchikawa K Naitoh T Inoue 《Canadian Metallurgical Quarterly》1998,118(3):126-130
Clinical diagnosis of canine nasal mite (Pneumonyssoides caninum) infection is difficult due to the mite's location in the caudal nasal cavity and frontal sinuses. The current study was performed to evaluate the efficacy of milbemycin oxime in treating dogs with nasal mite infection. A prospective open uncontrolled study included 20 dogs with case histories indicating possible nasal mite infection. Inclusion criteria consisted of either nasal mites being demonstrated (group 1, four dogs), or suspicious clinical signs with no other apparent causes, combined with eosinophilia (group 2, 16 dogs). Milbemycin oxime 1 mg/kg was given orally three times at 10-day intervals. In 17 (85 per cent) dogs, clinical signs resolved completely following milbemycin therapy; within 10 days of the first treatment in 13 cases (group 1, four dogs; group 2, nine dogs) and within 14 days in four cases. In the remaining three dogs clinical signs persisted but were diminished. 相似文献
2.
Katie L. J. Cederberg Umaer Hanif Vicente Peris Sempere Julien Hdou Eileen B. Leary Logan D. Schneider Ling Lin Jing Zhang Anne M. Morse Adam Blackman Paula K. Schweitzer Suresh Kotagal Richard Bogan Clete A. Kushida Yo-El S. Ju Nayia Petousi Chris D. Turnbull Emmanuel Mignot The STAGES Cohort Investigator Group 《International journal of molecular sciences》2022,23(14)
Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea–hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke. 相似文献
3.
T. Fujitani T. Matsuda Y. Kushida S. Ogihara T. Uchijima J. Nakamura 《Catalysis Letters》1997,49(3-4):175-179
The effect of ZnO/SiO2 in a physical mixture of Cu/SiO2 and ZnO/SiO2 on methanol synthesis from CO2 and H2 was studied to clarify the role of ZnO in Cu/ZnO-based catalysts. An active Cu/SiO2 was prepared by the following procedure: the Cu/SiO2 and ZnO/SiO2 catalysts with a different SiO2 particle size were mixed and reduced with H2 at 523-723 K, and the Cu/SiO2 was then separated from the mixture using a sieve. The methanol synthesis activity of the Cu/SiO2 catalyst increased with the reduction temperature and was in fairly good agreement with that previously obtained for the
physical mixture of Cu/SiO2 and ZnO/SiO2. These results indicated that the active site for methanol synthesis was created on the Cu/SiO2 upon reduction of the physical mixture with H2. It was also found that ZnO itself had no promotional effect on the methanol synthesis activity except for the role of ZnO
to create the active site. The active site created on the Cu/SiO2 catalyst was found not to promote the formation of formate from CO2 and H2 on the Cu surface based on in situ FT-IR measurements. A special formate species unstable at 523 K with an OCO asymmetric
peak at ~1585 cm-1 was considered to be adsorbed on the active site.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
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Y Kageyama Y Koide A Yoshida M Uchijima T Arai S Miyamoto T Ozeki M Hiyoshi K Kushida T Inoue 《Canadian Metallurgical Quarterly》1998,161(3):1542-1548
Collagen-induced arthritis (CIA) is an arthritic model that was developed after immunization with type II collagen (CII). Apparently, contradictory results have been reported regarding the role of IFN-gamma in the development of CIA. Therefore, we employed IFN-gamma R-deficient mice to study the role of IFN-gamma. To introduce the CIA susceptibility gene (H-2q), IFN-gamma R-deficient (H-2b/b/IFN-gamma R-/-) mice were mated with DBA/1 (H-2q/q/IFN-gamma R+/+) mice; next, the F1 mice were interbred to yield F2 offspring bearing different combinations of H-2 (H-2q/q, H-2q/b, and H-2b/b) and IFN-gamma R (IFN-gamma R+/+, IFN-gamma R+/-, and IFN-gamma R-/-) genes. Although the H-2q allele appeared to confer susceptibility to CIA, mice that were homozygous for the IFN-gamma R mutation showed a substantially decreased incidence and severity of CIA. The CII-specific IgG levels of serum samples, which are known to be involved in the development of CIA, were remarkably reduced in IFN-gamma R-/- mice. Furthermore, the anti-CII IgG2a levels controlled by IFN-gamma R were significantly reduced in IFN-gamma R-/- F2 mice compared with those seen in IFN-gamma R+/+ and IFN-gamma R+/- mice, although the levels of all IgG subclass Abs examined were lower in IFN-gamma R-/- mice than in IFN-gamma R+/+ mice. No clear evidence of the imbalance of Th1/Th2 cytokines was observed in CII-immunized, IFN-gamma R-deficient mice. Taken together, these results suggest that IFN-gamma exacerbates CIA by affecting, at least, levels of CII-specific IgG Ab rather than the imbalance of Th1/Th2 cells. 相似文献
9.
We studied 42 infertile men, who had been surgically treated with modified Palomo method, with intraoperative phlebography of single or multiple testicular veins. We evaluated the efficacy of the performed procedure as well as the presence of other ways of recoil outflow and the connections between the venous vessels of the right testis. In 42 cases surgically treated men with varicocele only in 4 cases the varicocele have been observed additionally on the right side. We are of the opinion that the intraoperative phlebography allows us to performed the proper and the most effective method of the operation of varicocele. 相似文献
10.
Moriyoshi Kushida Ayaho Miyamoto Kazuya Kinoshita 《Canadian Metallurgical Quarterly》1997,11(4):238-247
Efforts to develop practical expert systems have mostly concentrated on how to implement experience-based machine learning successfully. Recently several active research projects on machine learning have been undertaken from the viewpoint of knowledge-based management. The aim of this study is to develop the Concrete Bridge Rating (Diagnosis) Prototype Expert System with machine learning, employing the combination of a neural network and bidirectional associative memories (BAM). The introduction of machine learning into this system facilitates knowledge-based refinement. By applying the system to an actual in-service bridge, it has been verified that the machine learning method employed that uses the results of questionnaire surveys involving bridge experts is effective for the system. 相似文献