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1.
Theoretical and experimetal methods have been developed to characterize the effect of mechanical loading on the mesoscopic
and macroscopic mechanical state of polycrystalline materials. Ferritic and austenitic single-phase materials were first analyzed,
then phase interaction was studied in a multiductile phase material (austeno-ferritic duplex steel) and a natural reinforced
composite (pearlitic steel). The theoretical method is based on the self-consistent approach in which elastic and plastic
characteristics of the phases have been applied through the micromechanical behavior of single-crystal-using slip systems
and microscopic hardening. The effects of a crystallographic texture and phase interaction during loading and after unloading
were studied. The elastic and plastic anisotropy of the grains having the same crystallographic orientation were assessed
by diffraction strain analysis. The simulation was compared with the experiments performed using the X-ray diffraction technique.
In the considered duplex and pearlitic steels, it was observed that the ferrite stress state is much lower than the austenite
and cementite ones. The results of diffraction strain distribution have showed the pertinence of the models and give valuable
information, for example, for the yield stress and the hardening parameters of each phase in a two-phase material. 相似文献
2.
This review summarizes papers published during 1991 and 1992. The poor results obtained in the postneurosurgical treatment of gliomas led researchers to pursue attempts to try to overcome glioma cell resistance. The intra-arterial route was explored in several phase II studies with new drugs and even immunoconjugates; rates of response between 30% to 60% were obtained. New drugs (fotemustine, eflornithine, and estramustine) or combined protocols planned to circumvent chemoresistance were tested and showed some efficiency with moderate toxicity, enlarging the number of drugs available against malignant gliomas. On the contrary, two retrospective analyses warned about the risk of reduction of median time to survival due to adjuvant chemotherapy in anaplastic astrocytomas; this finding, if confirmed, would suggest to defer chemotherapy at the time of recurrence in this type of glial tumor. Immunobiologic therapies as immunomodifiers, immunoconjugates, or cytotoxic lymphocyte-activated killer cells and tumor-infiltrating lymphocytes were tested and allowed some responses to be obtained. In young children, chemotherapy regimens were found to be efficient in malignant plexus choroid carcinomas and low-grade gliomas, allowing radiation therapy to be deferred. Many studies were methodologically unsatisfactory because of uncertain pathology grouping, noncompliance to initial protocols, or too small populations of patients. 相似文献
3.
4.
A Blume K Seifert CJ Lebrun E M?llenhoff P Gass T Unger T Herdegen 《Canadian Metallurgical Quarterly》1998,241(2-3):87-90
Binding to olfactory receptors is the first step in odorant and pheromonal recognition and discrimination. These receptors constitute one of the most important, although poorly known, families of neuronal receptors. In this study we used degenerated oligonucleotides and a RT-PCR approach to selectively amplify olfactory receptors in the nasal epithelium of the domestic pig Sus scrofa. Several combinations of oligonucleotide were tested and allowed the isolation of eleven different partial sequences belonging to the seven transmembrane olfactory receptor family. These receptors formed a separate family within the seven transmembrane receptor superfamily in pigs. Using the criteria of Ben Arie et al. [Ben-Arie N., Lancet D., Taylor C., Khen M., Walker N., Ledbetter DH., Carrozzo R., Patel K., Sheer D., Lehrah H. and North M., Hum. Mol. Genet., 3 (1994) 229-235], the 11 receptors described here can be classified into three known families and seven subfamilies (one known and six new). 相似文献
5.
Improving security and performance of an Ad Hoc network through a multipath routing strategy 总被引:1,自引:0,他引:1
Hervé Aiache François Haettel Laure Lebrun Cédric Tavernier 《Journal in Computer Virology》2008,4(4):267-278
Privacy and security solutions require today the protection of personal information so that it may not be disclosed to unauthorized
participant for illegal purposes. It is a challenge to address these issues in networks with strong constraints such as Ad
Hoc network. The security increase is often obtained with a quality of service (QoS) decrease. We propose in this paper a
solution that provides at the anonymity, security to Ad Hoc network with a limited impact on QoS. This method could be efficient
against some viral attacks. We also give some security proofs of our solution for Ad Hoc networks.
The work of Hervé Aiache and Cédric Tavernier was supported by DISCREET, IST project no. 027679, funded in part by the European
Commission’s Information Society Technology 6th Framework Programme. 相似文献
6.
A highly nonlinear increase in electrical conductivity and concomitant photoemission occurs not only during “flash sintering” but also in presintered, dense specimens. We report results from experiments with dense specimens that show a strong correspondence between the intensity of photoemission and electrical conductivity of specimens under a variety of conditions of the electrical parameters. It is proposed that both properties are related to the concentration of electron–hole pairs generated in such experiments. 相似文献
7.
8.
The Change of X‐ray Diffraction Peak Width During in situ Conventional Sintering of Nanoscale Powders
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Jean‐Marie Lebrun Shikhar K. Jha Kiran S. Naik Kevin C. Seymour Waltraud M. Kriven Rishi Raj 《Journal of the American Ceramic Society》2016,99(3):765-768
Diffraction peaks of nanoscale particles of 3 mol% yttria‐stabilized zirconia become sharper as the powder sinters. The reduction in the peak width is correlated with the increase in density. The sharpening of the peak agrees reasonably well with the remaining free surface area as the sample sinters. Therefore, high curvature of the free surface of the pores is assumed to lead to peak broadening (the grain boundaries that grow at the expense of the free surfaces of the pores do not have this curvature). The change in the grain size during sintering does not make a significant contribution to peak width. 相似文献
9.
Dr. Marie Monestier Peggy Charbonnier Dr. Christelle Gateau Dr. Martine Cuillel Faustine Robert Colette Lebrun Dr. Elisabeth Mintz Prof. Olivier Renaudet Dr. Pascale Delangle 《Chembiochem : a European journal of chemical biology》2016,17(7):590-594
Liver cells are an essential target for drug delivery in many diseases. The hepatocytes express the asialoglycoprotein receptor (ASGPR), which promotes specific uptake by means of N‐acetylgalactosamine (GalNAc) recognition. In this work, we designed two different chemical architectures to treat Wilson's disease by intracellular copper chelation. Two glycoconjugates functionalized with three or four GalNAc units each were shown to enter hepatic cells and chelate copper. Here, we studied two series of compounds derived from these glycoconjugates to find key parameters for the targeting of human hepatocytes. Efficient cellular uptake was demonstrated by flow cytometry using HepG2 human heptic cells that express the human oligomeric ASGPR. Dissociation constants in the nanomolar range showed efficient multivalent interactions with the receptor. Both architectures were therefore concluded to be able to compete with endogeneous asialoglycoproteins and serve as good vehicles for drug delivery in hepatocytes. 相似文献
10.
Jean-Denis Troadec Stphanie Gaig Manon Barbot Bruno Lebrun Rym Barbouche Anne Abysique 《International journal of molecular sciences》2022,23(2)
The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level. 相似文献