Characterization of type I 5 alpha-reductase activity in DU145 human prostatic adenocarcinoma cells

Each amino acid is represented by a vector of numerical measurements for the attributes of volume, area, hydrophilicity, polarity, hydrogen bonding, shape, and charge. Inter-residue distances are then calculated according to common metrics, and we introduce a new clustering objective function derived from information-theoretic considerations. The arguments of the function are the inter-object distances of the things to be clustered: in this case the amino acids. By means of approximating the solution of an integer programming problem, then, the residues are partitioned into clusters. The clusters obtained are compared with groups obtained in substitution/mutation studies and found to be similar. Thus, probably the strongest and most objective evidence to date is supplied for believing that physico-chemical properties account for the viability of substitutions and that the important similarities/differences are explained by a relatively small and simple set of properties.     

Ultrasonic feature-based classification of the interfacial condition in composite adhesive joints

The sensitivity of ultrasonic features to the condition of the adherend-adhesive interface in composite joints was studied. The inspected specimens represent different bonding characteristics due to the variety of surface pretreatments to the composite adherends. Each signal obtained from ultrasonic inspection of a specimen was characterized by a feature vector, consisting of features derived from both the time and frequency domain representations of the signal. Some of the features were found to be significantly sensitive to the interfacial characteristics of the joints. The sensitivity was verified by means of conventional statistical tests. The sensitivity of the features enabled the application of basic pattern recognition techniques for the classification of the joints according to the surface preparation of the adherends.     

Electronic characterization of heterojunctions by surface potential monitoring

An original approach for studying the formation of semiconductor heterojunctions and their electronic properties is discussed and illustrated. Monitoring the changes in the surface potential during the heterojunction formation lends itself to direct measurement of the band discontinuities, Debye length, and the width of the space-charge region at heterojunction interfaces. The contribution of an interface dipole is considered. The technique is demonstrated by a technologically significant experimental example.     

Ureteropelvic junction obstruction: relation of etiology and age at surgical repair to clinical outcome

Ureteropelvic junction (UPJ) obstruction is a congenital anomaly either caused by intrinsic narrowing of the upper ureter or by extrinsic pressure on the ureter caused by aberrant vessels or fibrous bands. We reviewed 121 cases of pyeloplasties performed in our department for UPJ obstruction. The cases were grouped by age and by the underlying pathology. Postoperative urographic evaluation showed that dismembered pyeloplasty was successful in 98.4% of the patients, with no significant difference between age groups. Persistence or recurrence of preoperative symptoms occurred in some patients (16.6%). Extrinsic obstruction of the ureter was associated with better postoperative clinical results and less recurrence of symptoms.     

Effects of electron prebunching on the radiation growth rate of acollective (Raman) free-electron laser amplifier

Experiments are reported on the effects of electron prebunching in a mildly relativistic, low-current (200-KV, 1-A) free-electron laser amplifier operating in the collective (Raman) regime at a frequency of ~10 GHz. Prebunching is established by injecting an electromagnetic wave into a bifilar helical wiggler and then transporting the bunched beam into a second magnetic wiggler region. The wave growth rate is deduced from measurements of the radiation intensity as a function of interaction length. Observations show that prebunching can increase the radiation growth rate manyfold as compared with a system without prebunching. Studies are presented both in the small-signal (linear) regime, and in the nonlinear (saturated) regime     

Phase transformations in metastable Ti-V alloys induced by high pressure treatment

Changes in crystal structure induced by the application of high pressure up to 9.2 GPa were studied in metastable Ti-V alloys in wide concentration range (2 to 40 pct V) by transmission electron miroscopy and correlated with the results of quantitative X-ray diffraction analysis. The high pressure treatment causes formation of the ω phase in Ti-V metastable alloys, and changes its morphology after quenching. The amount of ω phase remaining after releasing the pressure is significantly larger than that obtained upon quenching. When the vanadium content in the alloy was more than 30 at pct, ω-like correlated displacements were observed and the corresponding electron diffraction pattern exhibited characteristic diffuse streaking. CH. LEIBOVITCH, formerly Graduate Student     

Does hormone replacement therapy inhibit coronary artery calcification?

OBJECTIVE: To determine the association between the use of hormone replacement therapy (HRT) and coronary calcium, in postmenopausal women who had no history of coronary artery disease by double helical computed tomography (CT). METHODS: We used CT to compare the prevalence and extent of coronary calcium in 41 postmenopausal women who were on HRT from the first year of menopause and 37 age-matched controls who had never used HRT. RESULTS: Both groups had a similar rate of smoking, hypertension, a positive family history, and hypercholesterolemia. Coronary calcification was observed in 28.2% of the 78 women studied. The prevalence of coronary calcium was significantly lower among HRT users: six of the 47 (14.6%), compared with 16 of the 37 nonusers (43.2%) (P < .01). The recorded risk factors had no effect on the prevalence of coronary calcium. Stepwise logistic regression analysis, including age, coronary risk factors, and HRT use as independent variables, yielded HRT as the only variable determining the presence of coronary calcium (odds ratio = 0.2; 95% confidence interval 0.06, 0.63; P = .006). CONCLUSION: The lower incidence of coronary calcium in the HRT users suggests that HRT is associated with decreased prevalence of the coronary calcification.     

Performance characterization of III-V power devices

The power performance of GaAs/AlGaAs pseudomorphic high electron mobility transistors (PHEMTs) has been modeled by using the statistical Design of Experiment approach. Empirical models for the small signal gain, output power and power added efficiency have been developed. The “walk-out/in” phenomenon has been observed in the devices as a result of power measurements. The evolution of surface photovoltage spectra after RF power stress indicates accumulation of positive electrical charge in the buffer and the surface layer of the devices.