Child Support Receipt,Mobility, and Housing Quality

This study uses administrative records for the state of Wisconsin as well as Zillow Real Estate data on median house values to examine the associations between the regularity of child support receipt on moves and changes in housing values following moves. Our sample consists of 13 329 custodial mothers with new orders from 2002 to 2006. Across several measures of child support and specifications of moves, regular receipt is negatively associated with any moves and with more than one move a year, holding constant the value of the child support received. In models examining associations between regularity and changes in housing quality after a move, an additional month of child support within 25 per cent of the order amount is associated with an $890 increase in housing value. These results imply that policy-makers concerned with housing stability consider both the regularity and absolute value of child support when considering family well-being.     

Hybrid Wireless Sensors Deployment Scheme with Connectivity and Coverage Maintaining in Wireless Sensor Networks

With the rapid growth of the internet of things (IoT), an impressive number of IoT’s application based on wireless sensor networks (WSNs) has been deployed in various domain. Due to its wide ranged applications, WSNs that have the capability to monitor a given sensing field, became the most used platform of IoT. Therefore, coverage becomes one of the most important challenge of WSNs. The search for better positions to assign to the sensors in order to control each point of an area of interest and the collection of data from sensors are major concerns in WSNs. This work addresses these problems by providing a hybrid approach that ensures sensors deployment on a grid for targets coverage while taking into account connectivity. The proposed sequential hybrid approach is based on three algorithms. The first places the sensors so as to all targets are covered. The second removes redundancies from the placement algorithm to reduce the number of sensors deployed. The third one, based on the genetic algorithm, aims to generate a connected graph which provide a minimal path that links deployed sensors and sink. Simulations and a comparative study were carried out to prove the relevance of the proposed method.

     

Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease

Radiation-induced heart disease (RIHD) is a potential late side-effect of thoracic radiotherapy resulting in left ventricular hypertrophy (LVH) and fibrosis due to a complex pathomechanism leading to heart failure. Angiotensin-II receptor blockers (ARBs), including losartan, are frequently used to control heart failure of various etiologies. Preclinical evidence is lacking on the anti-remodeling effects of ARBs in RIHD, while the results of clinical studies are controversial. We aimed at investigating the effects of losartan in a rat model of RIHD. Male Sprague-Dawley rats were studied in three groups: (1) control, (2) radiotherapy (RT) only, (3) RT treated with losartan (per os 10 mg/kg/day), and were followed for 1, 3, or 15 weeks. At 15 weeks post-irradiation, losartan alleviated the echocardiographic and histological signs of LVH and fibrosis and reduced the overexpression of chymase, connective tissue growth factor, and transforming growth factor-beta in the myocardium measured by qPCR; likewise, the level of the SMAD2/3 protein determined by Western blot decreased. In both RT groups, the pro-survival phospho-AKT/AKT and the phospho-ERK1,2/ERK1,2 ratios were increased at week 15. The antiremodeling effects of losartan seem to be associated with the repression of chymase and several elements of the TGF-β/SMAD signaling pathway in our RIHD model.     

Current Barriers to Large‐scale Interoperability of Traceability Technology in the Seafood Sector

Interoperability is a critical component of full‐chain digital traceability, but is almost nonexistent in the seafood industry. Using both quantitative and qualitative methodology, this study explores the barriers impeding progress toward large‐scale interoperability among digital traceability systems in the seafood sector from the perspectives of seafood companies, technology vendors, and supply chains as a whole. We highlight lessons from recent research and field work focused on implementing traceability across full supply chains and make some recommendations for next steps in terms of overcoming challenges and scaling current efforts.     

Investigation of the Antiremodeling Effects of Losartan,Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model

Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development of chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling of various etiologies. The beta-3 adrenergic receptor agonist mirabegron was reported to improve chronic heart failure. Here we investigated the effects of losartan, mirabegron and their combination on the development of DOXO-induced chronic cardiotoxicity. Male Wistar rats were divided into five groups: (i) control; (ii) DOXO-only; (iii) losartan-treated DOXO; (iv) mirabegron-treated DOXO; (v) losartan plus mirabegron-treated DOXO groups. The treatments started 5 weeks after DOXO administration. At week 8, echocardiography was performed. At week 9, left ventricles were prepared for histology, qRT-PCR, and Western blot measurements. Losartan improved diastolic but not systolic dysfunction and ameliorated SERCA2a repression in our DOXO-induced cardiotoxicity model. The DOXO-induced overexpression of Il1 and Il6 was markedly decreased by losartan and mirabegron. Mirabegron and the combination treatment improved systolic and diastolic dysfunction and significantly decreased overexpression of Smad2 and Smad3 in our DOXO-induced cardiotoxicity model. Only mirabegron reduced DOXO-induced cardiac fibrosis significantly. Mirabegron and its combination with losartan seem to be promising therapeutic tools against DOXO-induced chronic cardiotoxicity.     

Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer

Targeting dysregulated Ca²⁺ signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca²⁺ entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA approval to be used in targeted therapy for patients with EGFR mutation-positive cancers. While preclinical studies and clinical trials have shown that afatinib has benefits for esophageal cancer patients, it is not known whether a combination of afatinib and RP4010 could achieve better anticancer effects. Since TKI can alter intracellular Ca²⁺ dynamics through EGFR/phospholipase C-γ pathway, in this study, we evaluated the inhibitory effect of afatinib and RP4010 on intracellular Ca²⁺ oscillations in KYSE-150, a human esophageal squamous cell carcinoma cell line, using both experimental and mathematical simulations. Our mathematical simulation of Ca²⁺ oscillations could fit well with experimental data responding to afatinib or RP4010, both separately or in combination. Guided by simulation, we were able to identify a proper ratio of afatinib and RP4010 for combined treatment, and such a combination presented synergistic anticancer-effect evidence by experimental measurement of intracellular Ca²⁺ and cell proliferation. This intracellular Ca²⁺ dynamic-based mathematical simulation approach could be useful for a rapid and cost-effective evaluation of combined targeting therapy drugs.     

The Impact of Housing Subsidies and Prices on Mothers' Living Arrangements: Evidence from the Census

Although rarely the primary focus of study, housing subsidies and prices influence the most fundamental decisions about family living. This analysis uses 1980, 1990 and 2000 US Census data to examine the effects of housing prices and subsidies on the living arrangements of mothers with young children while controlling for welfare benefit levels, unemployment rates, gender ratios, child support enforcement and personal characteristics. Results suggest that housing prices are positively associated with all shared arrangements relative to living alone, while housing subsidies are negatively associated with marriage and living with family relative to living alone.