Optimal Control of the Primary Drying Stage of Freeze Drying of Solutions in Vials Using Variational Calculus

The problem of operating freeze drying of pharmaceutical products in vials placed in trays of a freeze dryer to remove free water (in frozen state) at a minimum time was formulated as an optimal control problem. Two different types of freeze dryer designs were considered. In type I freeze dryer design, upper and lower plate temperatures were controlled together, while in type II freeze dryer design, upper and lower plate temperatures were controlled independently. The heat input to the material being dried and the drying chamber pressure were considered as control variables. Constraints were placed on the system state variables by the melting and scorch temperatures during primary drying stage. Necessary conditions of optimality for the primary drying stage of freeze drying process in vials are derived and presented. Furthermore, an approach for constructing the optimal control policies that would minimize the drying time for the primary drying stage was given. In order to analyze optimal control policy for the primary drying stage of the freeze-drying process in vials, a rigorous multi-dimensional unsteady state mathematical model was used. The theoretical approach presented in this work was applied in the freeze drying of skim milk. Significant reductions in the drying times of primary drying stage of freeze drying process in vials were obtained, as compared to the drying times obtained from conventional operational policies.     

Characterization of rheological properties of systems containing sugar substitutes and carrageenan

The effects of addition of κ-carrageenan to solutions containing 40% (w/w) sugar substitute on the rheological properties of these systems were investigated at 25 °C using a rotational viscometer at rotational speeds of 6, 12, 30, and 60 rev min⁻¹. The flow behaviour of the solutions was adequately described by the power law model with or without yield stress. The consistency index ( K ) and the flow behaviour index ( n ) were determined from shear stress vs. shear rate data. The flow parameters of the solutions depended on the carrageenan concentration. The apparent viscosities of the systems decreased with increasing shear rate, indicating pseudoplastic behaviour. The final carrageenan concentration was found to be an effective factor controlling the degree of sliminess of the model food systems studied.     

Microarchitectures for Managing Chip Revenues under Process Variations

As transistor feature sizes continue to shrink intothe sub-90nm range and beyond, the effects of process variationson critical path delay and chip yields have amplified. A commonconcept to remedy the effects of variation is speed-binning, bywhich chips from a single batch are rated by a discrete range offrequencies and sold at different prices. In this paper, we discussstrategies to modify the number of chips in different bins andhence enhance the profits obtained from them. Particularly, wepropose a scheme that introduces a small Substitute Cacheassociated with each cache way to replicate the data elementsthat will be stored in the high latency lines. Assuming a fixedpricing model, this method increases the revenue by as much as13.8% without any impact on the performance of the chips.     

Methacrylic acid–acrylamide-g-poly(ethyleneterephthalate) fibres for urea hydrolysis

This paper presents the results of urease immobilization onto methacrylic acid–acrylamide grafted poly(ethyleneterephthalate) fibres. The graft yield strongly affected the maximum activity of the immobilized enzyme up to a value of 70·2%. Higher grafting caused a decline in urease activity and led to the degradation of the fibres. The minor changes observed in K_m and V_max demonstrated that the conformational changes existed during immobilization were not extensive. However, 70·2% methacrylic acid–acrylamide-g-fibres containing urease were more stable towards acidic and alkaline pH, high temperature and storage conditions compared with free enzyme. Apart from the increase in stability to heat inactivation, the initial enzymatic activity of the urease–fibre system remained almost unchanged even after 40 repeated assays corresponding to 10 h of operation in 4 months, indicating the excellent durability of the system.     

Mullite for Structural, Electronic, and Optical Applications

Mullite (3Al₂O₃·2SiO₂) is becoming increasingly important in electronic, optical, and high-temperature structural applications. This paper reviews the current state of mullite-related research at a fundamental level, within the framework of phase equilibria, crystal structure, synthesis, processing, and properties. Phase equilibria are discussed in terms of the problems associated with the nucleation kinetics of mullite and the large variations observed in the solid-solution range. The incongruent melting behavior of mullite is now widely accepted. Large variations in the solid solubility from 58 to 76 mol% alumina are related to the ordering/disordering of oxygen vacancies and are strongly coupled with the method of synthesis used to form mullite. Similarly, reaction sequences which lead to the formation of mullite upon heating depend on the spatial scale at which the components are mixed. Mixing at the atomic level is useful for low-temperature (<1000°C) synthesis of mullite but not for low-temperature sintering. In contrast, precursors that are segregated are better suited for low-temperature (1250° to 1500°C) densification through viscous deformation. Flexural strength and creep resistance at elevated temperatures are significantly affected by the presence of glassy boundary inclusions; in the absence of glassy inclusions, polycrystalline mullite retains >90% of its room-temperature strength to 1500°C and displays very high creep resistance. Because of its low dielectric constant, mullite has now emerged as a substrate material in high-performance packaging applications. Interest in optical applications mainly centers on its applicability as a window material within the mid-infrared range.     

Recovery of sensor embedded washing machines using a multi-kanban controlled disassembly line

Product recovery involves the recovery of materials and components from returned or end-of-life products. Disassembly, an element of product recovery, is the systematic separation of an assembly into its components, subassemblies or other groupings. Stricter environmental regulations together with dramatic decrease in natural resources and landfills have increased the importance of disassembly as all product recovery options require some level of disassembly. Due to changes made during the lifetime of a product by customers or service personnel, the number and the version of components prior to disassembly is unknown. Customers may also discriminate between and demand different versions of components. The existence of non-functional components further adds to the uncertainty associated with disassembly yield. Sensors implanted into products during their production can address this uncertainty by providing information on the number, condition and version of components prior to disassembly. In this study, we evaluate the impact of sensor embedded products (SEPs) on the various performance measures of a washing machine (WM) disassembly line controlled by a multi-kanban system, which takes into consideration the highly stochastic behavior of the line while managing material and kanban flows. First, separate design of experiments studies based on orthogonal arrays are performed for conventional products and SEPs. In order to observe the response of each experiment, detailed discrete event simulation (DES) models for both types of products are developed considering the precedence relationships among the components of a WM. Then, pair-wise t-tests are conducted to compare the two cases based on different performance measures. According to the results, SEPs provide significant reductions in all costs (viz., backorder, holding, disassembly, disposal, testing and transportation) while increasing revenue and profit.     

Towards quality requirements via animated formal specifications

Assuring a high quality requirements specification document involves both an early validation process and an increased level of participation. An approach and its supporting environment which combines the benefits of a formal system specification and its subsequent execution via a rapid prototype is reported. The environment assists in the construction, clarification, validation and visualisation of a formal specification. An illustrative case study demonstrates the consequences of assertions about system properties at this early stage of software development. Our approach involves the pragmatic combination of technical benefits of formal systems engineering based techniques with the context‐sensitive notions of increased participation of both developer and user stakeholders to move us closer towards a quality requirements specification document.     

Realization of reconfigurable filtering horn antennas using active frequency selective surfaces for GSM and LTE signal filtering

Herein, it is aimed to design an Active Frequency Selective Surface (AFSS) based high performance reconfigurable filtering antenna (Filtenna). The proposed AFSS unit element is consist of a single PIN diode with a simple microstrip patch design which performance characteristics are varies with the state of the diodes. The proposed unit elements have been used to form an array that is placed at the aperture of a double ridge horn antenna. With the variation in state of diodes, the antenna acts as a Filtenna module to filtering the incoming electromagnetic waves in frequency band of 1.8 to 2.8 GHz. From the experimental results, it is shown that the proposed Filtenna achieves a signal attenuation of 7.3 dBi at 2.1 GHz.     

Inhibitory effects of anethole and eugenol on the growth and toxin production of Aspergillus parasiticus

The antifungal and antiaflatoxigenic activity of anethole and eugenol which are active components of commonly used spices was studied against two strains of Aspergillus parasiticus. Anethole, up to concentration of 400 μg/ml where complete inhibition was observed, delayed growth and reduced mycelial weight but it showed a stimulative effect on the toxin production of both strains. At a concentration of 300 μg/ml, eugenol inhibited the growth of both strains; levels of eugenol below 200 μg/ml enhanced production of aflatoxin particularly by A. parasiticus NRRL 299.