Migration and the Multi-Dimensional Well-Being of Elderly Persons in Georgia

High rates of migration coupled with low formal social protection provisions may place many members of the elderly Georgian population in precarious living conditions that promote vulnerability and limit well-being achievement. This potential connection has been poorly explored in past literature, however, suggesting a need to better assess how the migration of an adult child may influence the multidimensional well-being of the elderly in Georgia. Using a novel dataset comprising 2202 elderly individuals across all regions of Georgia (excepting the territories of Abkhazia and South Ossetia), this paper proposes a multidimensional well-being index that has been specifically designed to encompass the unique resources and constraints faced by elderly individuals in different age cohorts. Following the construction of a multidimensional well-being index—comprised of domains including physical health and independence, housing well-being, social well-being, and emotional well-being—the outcomes of elderly individuals are compared by age and the presence/absence of adult children due to migration. Findings suggest that the migration status of an elderly person’s adult children is related to the attainment of well-being. Elderly individuals with a migrant child are more likely to attain well-being in physical health as well as in the overall multidimensional well-being index.     

Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction

An auxetic conductive cardiac patch (AuxCP) for the treatment of myocardial infarction (MI) is introduced. The auxetic design gives the patch a negative Poisson's ratio, providing it with the ability to conform to the demanding mechanics of the heart. The conductivity allows the patch to interface with electroresponsive tissues such as the heart. Excimer laser microablation is used to micropattern a re‐entrant honeycomb (bow‐tie) design into a chitosan‐polyaniline composite. It is shown that the bow‐tie design can produce patches with a wide range in mechanical strength and anisotropy, which can be tuned to match native heart tissue. Further, the auxetic patches are conductive and cytocompatible with murine neonatal cardiomyocytes in vitro. Ex vivo studies demonstrate that the auxetic patches have no detrimental effect on the electrophysiology of both healthy and MI rat hearts and conform better to native heart movements than unpatterned patches of the same material. Finally, the AuxCP applied in a rat MI model results in no detrimental effect on cardiac function and negligible fibrotic response after two weeks in vivo. This approach represents a versatile and robust platform for cardiac biomaterial design and could therefore lead to a promising treatment for MI.     

Modelling of crystallization process and optimization of the cooling strategy

To obtain a uniform and large crystal in seeded batch cooling crystallization, the cooling strategy is very important. In this study, an optimal cooling strategy is obtained through simulation and compared to linear and natural cooling strategies. A model for a crystallization process in a batch reactor is constructed by using population balance equation and material balance for solution concentration, and a prediction model for meta-stable limit is formulated by the dynamic meta-stable limit approach. Based on this model, an optimal cooling strategy is obtained using genetic algorithm with the objective function of minimizing the unwanted nucleation and maximizing the crystal growth rate. From the simulation results, the product from the optimal cooling strategy showed uniform and large crystal size distribution while products from the other two strategies contained significant amount of fine particles.